| Full name: isochorismatase domain containing 1 | Alias Symbol: CGI-111 | ||
| Type: protein-coding gene | Cytoband: 5q23.3 | ||
| Entrez ID: 51015 | HGNC ID: HGNC:24254 | Ensembl Gene: ENSG00000066583 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of ISOC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISOC1 | 51015 | 218170_at | -0.9437 | 0.1173 | |
| GSE20347 | ISOC1 | 51015 | 218170_at | -1.0053 | 0.0000 | |
| GSE23400 | ISOC1 | 51015 | 218170_at | -0.5232 | 0.0000 | |
| GSE26886 | ISOC1 | 51015 | 218170_at | -1.4726 | 0.0000 | |
| GSE29001 | ISOC1 | 51015 | 218170_at | -0.5311 | 0.0483 | |
| GSE38129 | ISOC1 | 51015 | 218170_at | -0.9169 | 0.0000 | |
| GSE45670 | ISOC1 | 51015 | 218170_at | -0.6218 | 0.0004 | |
| GSE53622 | ISOC1 | 51015 | 14333 | -0.8238 | 0.0000 | |
| GSE53624 | ISOC1 | 51015 | 14333 | -0.7166 | 0.0000 | |
| GSE63941 | ISOC1 | 51015 | 218170_at | -1.4617 | 0.0081 | |
| GSE77861 | ISOC1 | 51015 | 218170_at | -1.4889 | 0.0005 | |
| GSE97050 | ISOC1 | 51015 | A_23_P250982 | -0.6207 | 0.2193 | |
| SRP007169 | ISOC1 | 51015 | RNAseq | -1.3833 | 0.0001 | |
| SRP008496 | ISOC1 | 51015 | RNAseq | -1.4412 | 0.0000 | |
| SRP064894 | ISOC1 | 51015 | RNAseq | -0.5490 | 0.0006 | |
| SRP133303 | ISOC1 | 51015 | RNAseq | -0.5046 | 0.0173 | |
| SRP159526 | ISOC1 | 51015 | RNAseq | -0.4419 | 0.2691 | |
| SRP193095 | ISOC1 | 51015 | RNAseq | -1.2490 | 0.0000 | |
| SRP219564 | ISOC1 | 51015 | RNAseq | -0.4756 | 0.4971 | |
| TCGA | ISOC1 | 51015 | RNAseq | -0.2742 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ISOC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISOC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISOC1 | 51015 | 1 | 12 | 17 | |
| GSE20123 | ISOC1 | 51015 | 1 | 12 | 17 | |
| GSE43470 | ISOC1 | 51015 | 3 | 8 | 32 | |
| GSE46452 | ISOC1 | 51015 | 0 | 27 | 32 | |
| GSE47630 | ISOC1 | 51015 | 0 | 21 | 19 | |
| GSE54993 | ISOC1 | 51015 | 9 | 1 | 60 | |
| GSE54994 | ISOC1 | 51015 | 2 | 14 | 37 | |
| GSE60625 | ISOC1 | 51015 | 0 | 0 | 11 | |
| GSE74703 | ISOC1 | 51015 | 2 | 6 | 28 | |
| GSE74704 | ISOC1 | 51015 | 1 | 6 | 13 | |
| TCGA | ISOC1 | 51015 | 2 | 40 | 54 |
Total number of gains: 21; Total number of losses: 147; Total Number of normals: 320.
Somatic mutations of ISOC1:
Generating mutation plots.
Highly correlated genes for ISOC1:
Showing top 20/1337 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISOC1 | EIF4E3 | 0.7713 | 8 | 0 | 8 |
| ISOC1 | SLC27A6 | 0.758024 | 12 | 0 | 12 |
| ISOC1 | SORCS1 | 0.738887 | 4 | 0 | 4 |
| ISOC1 | CIPC | 0.736532 | 6 | 0 | 6 |
| ISOC1 | TPPP | 0.734964 | 3 | 0 | 3 |
| ISOC1 | STBD1 | 0.734913 | 3 | 0 | 3 |
| ISOC1 | RAP1A | 0.733657 | 11 | 0 | 11 |
| ISOC1 | RASSF5 | 0.731499 | 4 | 0 | 4 |
| ISOC1 | XKR4 | 0.72796 | 5 | 0 | 5 |
| ISOC1 | MRPS36 | 0.727801 | 7 | 0 | 7 |
| ISOC1 | CYP21A2 | 0.722719 | 3 | 0 | 3 |
| ISOC1 | MPC1 | 0.715318 | 10 | 0 | 10 |
| ISOC1 | GAB1 | 0.714313 | 9 | 0 | 8 |
| ISOC1 | SNORA68 | 0.713889 | 4 | 0 | 4 |
| ISOC1 | SFTA2 | 0.71161 | 3 | 0 | 3 |
| ISOC1 | RBFOX3 | 0.709895 | 3 | 0 | 3 |
| ISOC1 | WAC | 0.709206 | 4 | 0 | 3 |
| ISOC1 | ANO5 | 0.708115 | 6 | 0 | 6 |
| ISOC1 | TMEM114 | 0.705684 | 3 | 0 | 3 |
| ISOC1 | CLEC3B | 0.704387 | 3 | 0 | 3 |
For details and further investigation, click here
