| Full name: transient receptor potential cation channel subfamily A member 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8q21.11 | ||
| Entrez ID: 8989 | HGNC ID: HGNC:497 | Ensembl Gene: ENSG00000104321 | OMIM ID: 604775 |
| Drug and gene relationship at DGIdb | |||
TRPA1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04750 | Inflammatory mediator regulation of TRP channels |
Expression of TRPA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPA1 | 8989 | 217590_s_at | -0.2892 | 0.7602 | |
| GSE20347 | TRPA1 | 8989 | 217590_s_at | -0.1524 | 0.2065 | |
| GSE23400 | TRPA1 | 8989 | 217590_s_at | -0.1077 | 0.1156 | |
| GSE26886 | TRPA1 | 8989 | 217590_s_at | 0.0717 | 0.7802 | |
| GSE29001 | TRPA1 | 8989 | 217590_s_at | -0.5171 | 0.1445 | |
| GSE38129 | TRPA1 | 8989 | 217590_s_at | -0.1237 | 0.5623 | |
| GSE45670 | TRPA1 | 8989 | 217590_s_at | -0.0161 | 0.9755 | |
| GSE53622 | TRPA1 | 8989 | 13298 | 0.0031 | 0.9878 | |
| GSE53624 | TRPA1 | 8989 | 13298 | -0.1423 | 0.4342 | |
| GSE63941 | TRPA1 | 8989 | 217590_s_at | -7.7725 | 0.0000 | |
| GSE77861 | TRPA1 | 8989 | 217590_s_at | 0.0335 | 0.8586 | |
| GSE97050 | TRPA1 | A_21_P0000609 | 0.0350 | 0.8683 | ||
| SRP133303 | TRPA1 | 8989 | RNAseq | 0.5139 | 0.1899 | |
| SRP159526 | TRPA1 | 8989 | RNAseq | 2.0092 | 0.0373 | |
| SRP193095 | TRPA1 | 8989 | RNAseq | 0.6595 | 0.2038 | |
| TCGA | TRPA1 | 8989 | RNAseq | -1.2027 | 0.0019 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by TRPA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPA1 | 8989 | 15 | 1 | 14 | |
| GSE20123 | TRPA1 | 8989 | 16 | 1 | 13 | |
| GSE43470 | TRPA1 | 8989 | 18 | 1 | 24 | |
| GSE46452 | TRPA1 | 8989 | 20 | 2 | 37 | |
| GSE47630 | TRPA1 | 8989 | 23 | 0 | 17 | |
| GSE54993 | TRPA1 | 8989 | 0 | 19 | 51 | |
| GSE54994 | TRPA1 | 8989 | 30 | 0 | 23 | |
| GSE60625 | TRPA1 | 8989 | 0 | 4 | 7 | |
| GSE74703 | TRPA1 | 8989 | 15 | 1 | 20 | |
| GSE74704 | TRPA1 | 8989 | 11 | 0 | 9 | |
| TCGA | TRPA1 | 8989 | 51 | 2 | 43 |
Total number of gains: 199; Total number of losses: 31; Total Number of normals: 258.
Somatic mutations of TRPA1:
Generating mutation plots.
Highly correlated genes for TRPA1:
Showing top 20/66 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPA1 | TBX2 | 0.738043 | 4 | 0 | 4 |
| TRPA1 | ALPL | 0.732734 | 3 | 0 | 3 |
| TRPA1 | SLC38A11 | 0.731406 | 3 | 0 | 3 |
| TRPA1 | CCDC81 | 0.720603 | 3 | 0 | 3 |
| TRPA1 | SCN3A | 0.706623 | 4 | 0 | 3 |
| TRPA1 | TCTE3 | 0.696974 | 3 | 0 | 3 |
| TRPA1 | HYAL2 | 0.695622 | 3 | 0 | 3 |
| TRPA1 | ARSA | 0.69529 | 4 | 0 | 3 |
| TRPA1 | FAM110B | 0.693595 | 4 | 0 | 3 |
| TRPA1 | PHF1 | 0.691522 | 3 | 0 | 3 |
| TRPA1 | SSTR2 | 0.687061 | 3 | 0 | 3 |
| TRPA1 | PCYOX1L | 0.682582 | 3 | 0 | 3 |
| TRPA1 | LINC00968 | 0.679014 | 3 | 0 | 3 |
| TRPA1 | HMOX1 | 0.67591 | 3 | 0 | 3 |
| TRPA1 | SH2D5 | 0.668786 | 3 | 0 | 3 |
| TRPA1 | SEMA5A | 0.66233 | 4 | 0 | 3 |
| TRPA1 | ZBTB45 | 0.658813 | 3 | 0 | 3 |
| TRPA1 | PRAF2 | 0.658209 | 3 | 0 | 3 |
| TRPA1 | TCEAL7 | 0.651565 | 4 | 0 | 3 |
| TRPA1 | P2RX5 | 0.648873 | 3 | 0 | 3 |
For details and further investigation, click here
