| Full name: arylsulfatase A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 22q13.33 | ||
| Entrez ID: 410 | HGNC ID: HGNC:713 | Ensembl Gene: ENSG00000100299 | OMIM ID: 607574 |
| Drug and gene relationship at DGIdb | |||
Expression of ARSA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARSA | 410 | 204443_at | -0.1304 | 0.8473 | |
| GSE20347 | ARSA | 410 | 204443_at | -0.4896 | 0.0000 | |
| GSE23400 | ARSA | 410 | 204443_at | -0.3060 | 0.0000 | |
| GSE26886 | ARSA | 410 | 204443_at | -0.1438 | 0.4544 | |
| GSE29001 | ARSA | 410 | 204443_at | -0.6098 | 0.0099 | |
| GSE38129 | ARSA | 410 | 204443_at | -0.3404 | 0.0007 | |
| GSE45670 | ARSA | 410 | 204443_at | 0.3058 | 0.0525 | |
| GSE53622 | ARSA | 410 | 83747 | -0.1904 | 0.0019 | |
| GSE53624 | ARSA | 410 | 83747 | -0.4017 | 0.0000 | |
| GSE63941 | ARSA | 410 | 204443_at | -1.2306 | 0.0040 | |
| GSE77861 | ARSA | 410 | 204443_at | -0.0853 | 0.7735 | |
| GSE97050 | ARSA | 410 | A_33_P3229725 | 0.2269 | 0.4535 | |
| SRP007169 | ARSA | 410 | RNAseq | -1.5467 | 0.0002 | |
| SRP008496 | ARSA | 410 | RNAseq | -1.7733 | 0.0000 | |
| SRP064894 | ARSA | 410 | RNAseq | 0.2923 | 0.2482 | |
| SRP133303 | ARSA | 410 | RNAseq | -0.1075 | 0.3520 | |
| SRP159526 | ARSA | 410 | RNAseq | -0.3395 | 0.0526 | |
| SRP193095 | ARSA | 410 | RNAseq | -0.1301 | 0.2811 | |
| SRP219564 | ARSA | 410 | RNAseq | -0.0733 | 0.7396 | |
| TCGA | ARSA | 410 | RNAseq | -0.0818 | 0.1759 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ARSA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARSA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARSA | 410 | 3 | 8 | 19 | |
| GSE20123 | ARSA | 410 | 3 | 8 | 19 | |
| GSE43470 | ARSA | 410 | 2 | 8 | 33 | |
| GSE46452 | ARSA | 410 | 31 | 2 | 26 | |
| GSE47630 | ARSA | 410 | 9 | 4 | 27 | |
| GSE54993 | ARSA | 410 | 4 | 6 | 60 | |
| GSE54994 | ARSA | 410 | 11 | 8 | 34 | |
| GSE60625 | ARSA | 410 | 5 | 0 | 6 | |
| GSE74703 | ARSA | 410 | 2 | 6 | 28 | |
| GSE74704 | ARSA | 410 | 1 | 4 | 15 | |
| TCGA | ARSA | 410 | 26 | 16 | 54 |
Total number of gains: 97; Total number of losses: 70; Total Number of normals: 321.
Somatic mutations of ARSA:
Generating mutation plots.
Highly correlated genes for ARSA:
Showing top 20/196 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARSA | JSRP1 | 0.738195 | 3 | 0 | 3 |
| ARSA | DPYSL4 | 0.729529 | 3 | 0 | 3 |
| ARSA | GPR78 | 0.719349 | 3 | 0 | 3 |
| ARSA | HGD | 0.719294 | 3 | 0 | 3 |
| ARSA | FBXO15 | 0.712564 | 3 | 0 | 3 |
| ARSA | TRPA1 | 0.69529 | 4 | 0 | 3 |
| ARSA | BLK | 0.689216 | 3 | 0 | 3 |
| ARSA | NCR3 | 0.677272 | 4 | 0 | 3 |
| ARSA | GPR35 | 0.67431 | 4 | 0 | 3 |
| ARSA | ZKSCAN2 | 0.669049 | 3 | 0 | 3 |
| ARSA | PARP10 | 0.662226 | 3 | 0 | 3 |
| ARSA | TSPAN10 | 0.660535 | 4 | 0 | 3 |
| ARSA | LMAN1L | 0.656923 | 4 | 0 | 3 |
| ARSA | TMEM59L | 0.653793 | 4 | 0 | 3 |
| ARSA | PHAX | 0.651298 | 3 | 0 | 3 |
| ARSA | ADM2 | 0.650603 | 4 | 0 | 3 |
| ARSA | PTGER1 | 0.646964 | 5 | 0 | 4 |
| ARSA | EVX1 | 0.642231 | 3 | 0 | 3 |
| ARSA | LRCH4 | 0.642072 | 7 | 0 | 6 |
| ARSA | CD274 | 0.640923 | 5 | 0 | 3 |
For details and further investigation, click here
