| Full name: heme oxygenase 1 | Alias Symbol: bK286B10|HO-1 | ||
| Type: protein-coding gene | Cytoband: 22q12.3 | ||
| Entrez ID: 3162 | HGNC ID: HGNC:5013 | Ensembl Gene: ENSG00000100292 | OMIM ID: 141250 |
| Drug and gene relationship at DGIdb | |||
HMOX1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04066 | HIF-1 signaling pathway |
Expression of HMOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMOX1 | 3162 | 203665_at | -0.4285 | 0.5926 | |
| GSE20347 | HMOX1 | 3162 | 203665_at | -1.1176 | 0.0000 | |
| GSE23400 | HMOX1 | 3162 | 203665_at | -0.9689 | 0.0000 | |
| GSE26886 | HMOX1 | 3162 | 203665_at | -2.1626 | 0.0000 | |
| GSE29001 | HMOX1 | 3162 | 203665_at | -1.8181 | 0.0003 | |
| GSE38129 | HMOX1 | 3162 | 203665_at | -0.7674 | 0.0265 | |
| GSE45670 | HMOX1 | 3162 | 203665_at | 0.0619 | 0.9065 | |
| GSE53622 | HMOX1 | 3162 | 7218 | -0.6613 | 0.0000 | |
| GSE53624 | HMOX1 | 3162 | 140152 | -0.7435 | 0.0000 | |
| GSE63941 | HMOX1 | 3162 | 203665_at | -2.2659 | 0.0554 | |
| GSE77861 | HMOX1 | 3162 | 203665_at | -0.9450 | 0.1675 | |
| GSE97050 | HMOX1 | 3162 | A_23_P120883 | -0.2294 | 0.6690 | |
| SRP007169 | HMOX1 | 3162 | RNAseq | -2.0387 | 0.0003 | |
| SRP008496 | HMOX1 | 3162 | RNAseq | -2.2123 | 0.0000 | |
| SRP064894 | HMOX1 | 3162 | RNAseq | -1.0776 | 0.0022 | |
| SRP133303 | HMOX1 | 3162 | RNAseq | -1.1456 | 0.0000 | |
| SRP159526 | HMOX1 | 3162 | RNAseq | -0.8407 | 0.0942 | |
| SRP193095 | HMOX1 | 3162 | RNAseq | -1.5923 | 0.0000 | |
| SRP219564 | HMOX1 | 3162 | RNAseq | -0.5863 | 0.0657 | |
| TCGA | HMOX1 | 3162 | RNAseq | 0.0452 | 0.6972 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by HMOX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMOX1 | 3162 | 4 | 6 | 20 | |
| GSE20123 | HMOX1 | 3162 | 4 | 5 | 21 | |
| GSE43470 | HMOX1 | 3162 | 4 | 7 | 32 | |
| GSE46452 | HMOX1 | 3162 | 31 | 1 | 27 | |
| GSE47630 | HMOX1 | 3162 | 8 | 5 | 27 | |
| GSE54993 | HMOX1 | 3162 | 3 | 6 | 61 | |
| GSE54994 | HMOX1 | 3162 | 9 | 9 | 35 | |
| GSE60625 | HMOX1 | 3162 | 5 | 0 | 6 | |
| GSE74703 | HMOX1 | 3162 | 4 | 5 | 27 | |
| GSE74704 | HMOX1 | 3162 | 1 | 2 | 17 | |
| TCGA | HMOX1 | 3162 | 27 | 15 | 54 |
Total number of gains: 100; Total number of losses: 61; Total Number of normals: 327.
Somatic mutations of HMOX1:
Generating mutation plots.
Highly correlated genes for HMOX1:
Showing top 20/367 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMOX1 | CALCR | 0.737632 | 3 | 0 | 3 |
| HMOX1 | CD300LG | 0.723519 | 3 | 0 | 3 |
| HMOX1 | FAM71F1 | 0.70933 | 3 | 0 | 3 |
| HMOX1 | SPNS2 | 0.690091 | 4 | 0 | 4 |
| HMOX1 | TRPA1 | 0.67591 | 3 | 0 | 3 |
| HMOX1 | RNF157 | 0.675061 | 3 | 0 | 3 |
| HMOX1 | PRDM1 | 0.665218 | 9 | 0 | 8 |
| HMOX1 | TIMP2 | 0.661376 | 5 | 0 | 5 |
| HMOX1 | GRIPAP1 | 0.652008 | 3 | 0 | 3 |
| HMOX1 | ADAMTSL4 | 0.651934 | 7 | 0 | 5 |
| HMOX1 | RGL4 | 0.651338 | 4 | 0 | 3 |
| HMOX1 | PIM1 | 0.649027 | 10 | 0 | 9 |
| HMOX1 | METRNL | 0.64894 | 7 | 0 | 7 |
| HMOX1 | SFTA2 | 0.647764 | 3 | 0 | 3 |
| HMOX1 | DUSP5 | 0.647212 | 10 | 0 | 9 |
| HMOX1 | PRSS3 | 0.644162 | 9 | 0 | 7 |
| HMOX1 | KLHL10 | 0.643891 | 4 | 0 | 3 |
| HMOX1 | PMM1 | 0.642621 | 11 | 0 | 8 |
| HMOX1 | MXD1 | 0.640875 | 11 | 0 | 9 |
| HMOX1 | CDC20B | 0.639993 | 3 | 0 | 3 |
For details and further investigation, click here
