| Full name: transient receptor potential cation channel subfamily C member 1 | Alias Symbol: HTRP-1 | ||
| Type: protein-coding gene | Cytoband: 3q23 | ||
| Entrez ID: 7220 | HGNC ID: HGNC:12333 | Ensembl Gene: ENSG00000144935 | OMIM ID: 602343 |
| Drug and gene relationship at DGIdb | |||
TRPC1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance | |
| hsa04724 | Glutamatergic synapse | |
| hsa04726 | Serotonergic synapse |
Expression of TRPC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPC1 | 7220 | 205802_at | -0.2977 | 0.8064 | |
| GSE20347 | TRPC1 | 7220 | 205802_at | 0.3087 | 0.4028 | |
| GSE23400 | TRPC1 | 7220 | 205802_at | -0.1248 | 0.3018 | |
| GSE26886 | TRPC1 | 7220 | 205802_at | 1.7190 | 0.0001 | |
| GSE29001 | TRPC1 | 7220 | 205802_at | -0.0226 | 0.9677 | |
| GSE38129 | TRPC1 | 7220 | 205802_at | -0.2909 | 0.4147 | |
| GSE45670 | TRPC1 | 7220 | 205802_at | -1.7059 | 0.0002 | |
| GSE53622 | TRPC1 | 7220 | 41955 | -0.5040 | 0.0068 | |
| GSE53624 | TRPC1 | 7220 | 41955 | -0.3191 | 0.0192 | |
| GSE63941 | TRPC1 | 7220 | 205802_at | -2.1860 | 0.0265 | |
| GSE77861 | TRPC1 | 7220 | 205802_at | 0.1512 | 0.5159 | |
| GSE97050 | TRPC1 | 7220 | A_24_P28977 | -0.7473 | 0.1763 | |
| SRP007169 | TRPC1 | 7220 | RNAseq | 1.4217 | 0.0251 | |
| SRP064894 | TRPC1 | 7220 | RNAseq | 0.2258 | 0.5098 | |
| SRP133303 | TRPC1 | 7220 | RNAseq | 0.2052 | 0.6120 | |
| SRP159526 | TRPC1 | 7220 | RNAseq | -0.6314 | 0.1797 | |
| SRP193095 | TRPC1 | 7220 | RNAseq | 0.4374 | 0.1133 | |
| SRP219564 | TRPC1 | 7220 | RNAseq | -0.2000 | 0.7732 | |
| TCGA | TRPC1 | 7220 | RNAseq | -0.3744 | 0.0799 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by TRPC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPC1 | 7220 | 20 | 0 | 10 | |
| GSE20123 | TRPC1 | 7220 | 20 | 0 | 10 | |
| GSE43470 | TRPC1 | 7220 | 22 | 0 | 21 | |
| GSE46452 | TRPC1 | 7220 | 15 | 4 | 40 | |
| GSE47630 | TRPC1 | 7220 | 19 | 3 | 18 | |
| GSE54993 | TRPC1 | 7220 | 1 | 8 | 61 | |
| GSE54994 | TRPC1 | 7220 | 34 | 1 | 18 | |
| GSE60625 | TRPC1 | 7220 | 0 | 6 | 5 | |
| GSE74703 | TRPC1 | 7220 | 19 | 0 | 17 | |
| GSE74704 | TRPC1 | 7220 | 14 | 0 | 6 | |
| TCGA | TRPC1 | 7220 | 64 | 3 | 29 |
Total number of gains: 228; Total number of losses: 25; Total Number of normals: 235.
Somatic mutations of TRPC1:
Generating mutation plots.
Highly correlated genes for TRPC1:
Showing top 20/1029 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPC1 | EID3 | 0.788411 | 3 | 0 | 3 |
| TRPC1 | PKN3 | 0.771581 | 3 | 0 | 3 |
| TRPC1 | TCEAL5 | 0.764606 | 3 | 0 | 3 |
| TRPC1 | MCAM | 0.760151 | 9 | 0 | 9 |
| TRPC1 | TRIM47 | 0.759714 | 3 | 0 | 3 |
| TRPC1 | FIBIN | 0.75702 | 3 | 0 | 3 |
| TRPC1 | RIPPLY3 | 0.730272 | 3 | 0 | 3 |
| TRPC1 | TLN2 | 0.727953 | 4 | 0 | 3 |
| TRPC1 | RNASEH2C | 0.726177 | 4 | 0 | 3 |
| TRPC1 | LRRCC1 | 0.723213 | 3 | 0 | 3 |
| TRPC1 | C11orf96 | 0.721966 | 4 | 0 | 4 |
| TRPC1 | RASD2 | 0.717592 | 3 | 0 | 3 |
| TRPC1 | SLC26A10 | 0.717331 | 6 | 0 | 6 |
| TRPC1 | ZNF124 | 0.715333 | 3 | 0 | 3 |
| TRPC1 | SOBP | 0.714398 | 11 | 0 | 11 |
| TRPC1 | HMGN3 | 0.712533 | 3 | 0 | 3 |
| TRPC1 | NPNT | 0.712079 | 3 | 0 | 3 |
| TRPC1 | ZCRB1 | 0.711955 | 3 | 0 | 3 |
| TRPC1 | TRIM32 | 0.71018 | 3 | 0 | 3 |
| TRPC1 | PELP1 | 0.707796 | 3 | 0 | 3 |
For details and further investigation, click here
