| Full name: leucine rich repeat and coiled-coil centrosomal protein 1 | Alias Symbol: KIAA1764|CLERC|VFL1 | ||
| Type: protein-coding gene | Cytoband: 8q21.2 | ||
| Entrez ID: 85444 | HGNC ID: HGNC:29373 | Ensembl Gene: ENSG00000133739 | OMIM ID: 617791 |
| Drug and gene relationship at DGIdb | |||
Expression of LRRCC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRCC1 | 85444 | 231872_at | 0.1714 | 0.7814 | |
| GSE26886 | LRRCC1 | 85444 | 231872_at | 1.2783 | 0.0001 | |
| GSE45670 | LRRCC1 | 85444 | 231872_at | 0.1609 | 0.4271 | |
| GSE53622 | LRRCC1 | 85444 | 8240 | 0.4262 | 0.0005 | |
| GSE53624 | LRRCC1 | 85444 | 8240 | 0.6470 | 0.0000 | |
| GSE63941 | LRRCC1 | 85444 | 231872_at | 0.3920 | 0.6020 | |
| GSE77861 | LRRCC1 | 85444 | 231872_at | 0.3189 | 0.2178 | |
| GSE97050 | LRRCC1 | 85444 | A_23_P157527 | 0.2159 | 0.5821 | |
| SRP007169 | LRRCC1 | 85444 | RNAseq | 0.8738 | 0.0322 | |
| SRP008496 | LRRCC1 | 85444 | RNAseq | 1.1911 | 0.0007 | |
| SRP064894 | LRRCC1 | 85444 | RNAseq | 0.5548 | 0.0066 | |
| SRP133303 | LRRCC1 | 85444 | RNAseq | 0.4769 | 0.0392 | |
| SRP159526 | LRRCC1 | 85444 | RNAseq | 1.0452 | 0.0590 | |
| SRP193095 | LRRCC1 | 85444 | RNAseq | 0.4305 | 0.0172 | |
| SRP219564 | LRRCC1 | 85444 | RNAseq | 0.4759 | 0.2219 | |
| TCGA | LRRCC1 | 85444 | RNAseq | 0.0725 | 0.4009 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRRCC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRCC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRCC1 | 85444 | 13 | 2 | 15 | |
| GSE20123 | LRRCC1 | 85444 | 15 | 2 | 13 | |
| GSE43470 | LRRCC1 | 85444 | 18 | 1 | 24 | |
| GSE46452 | LRRCC1 | 85444 | 21 | 0 | 38 | |
| GSE47630 | LRRCC1 | 85444 | 23 | 0 | 17 | |
| GSE54993 | LRRCC1 | 85444 | 0 | 19 | 51 | |
| GSE54994 | LRRCC1 | 85444 | 29 | 1 | 23 | |
| GSE60625 | LRRCC1 | 85444 | 0 | 4 | 7 | |
| GSE74703 | LRRCC1 | 85444 | 15 | 1 | 20 | |
| GSE74704 | LRRCC1 | 85444 | 10 | 0 | 10 | |
| TCGA | LRRCC1 | 85444 | 54 | 2 | 40 |
Total number of gains: 198; Total number of losses: 32; Total Number of normals: 258.
Somatic mutations of LRRCC1:
Generating mutation plots.
Highly correlated genes for LRRCC1:
Showing top 20/730 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRCC1 | SFT2D3 | 0.84351 | 3 | 0 | 3 |
| LRRCC1 | NOL11 | 0.799489 | 3 | 0 | 3 |
| LRRCC1 | TEX261 | 0.76415 | 3 | 0 | 3 |
| LRRCC1 | PHF20 | 0.764013 | 4 | 0 | 4 |
| LRRCC1 | TBPL1 | 0.761398 | 3 | 0 | 3 |
| LRRCC1 | ZNF778 | 0.759584 | 3 | 0 | 3 |
| LRRCC1 | WDR43 | 0.753614 | 3 | 0 | 3 |
| LRRCC1 | TMEM223 | 0.746507 | 3 | 0 | 3 |
| LRRCC1 | VBP1 | 0.742214 | 3 | 0 | 3 |
| LRRCC1 | IRAK3 | 0.740448 | 3 | 0 | 3 |
| LRRCC1 | APH1B | 0.736665 | 4 | 0 | 4 |
| LRRCC1 | DMXL2 | 0.734097 | 4 | 0 | 3 |
| LRRCC1 | APOLD1 | 0.7338 | 3 | 0 | 3 |
| LRRCC1 | LSM7 | 0.733727 | 3 | 0 | 3 |
| LRRCC1 | DCAF7 | 0.733423 | 3 | 0 | 3 |
| LRRCC1 | NFS1 | 0.733279 | 4 | 0 | 4 |
| LRRCC1 | SORBS3 | 0.732601 | 3 | 0 | 3 |
| LRRCC1 | RPS21 | 0.731585 | 3 | 0 | 3 |
| LRRCC1 | POLR2B | 0.729335 | 3 | 0 | 3 |
| LRRCC1 | CWF19L2 | 0.725374 | 3 | 0 | 3 |
For details and further investigation, click here
