| Full name: transient receptor potential cation channel subfamily C member 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q27 | ||
| Entrez ID: 7222 | HGNC ID: HGNC:12335 | Ensembl Gene: ENSG00000138741 | OMIM ID: 602345 |
| Drug and gene relationship at DGIdb | |||
TRPC3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of TRPC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TRPC3 | 7222 | 206425_s_at | 0.0934 | 0.7246 | |
| GSE20347 | TRPC3 | 7222 | 206425_s_at | 0.1210 | 0.0913 | |
| GSE23400 | TRPC3 | 7222 | 206425_s_at | 0.0114 | 0.6613 | |
| GSE26886 | TRPC3 | 7222 | 210814_at | -0.0034 | 0.9699 | |
| GSE29001 | TRPC3 | 7222 | 206425_s_at | 0.0251 | 0.8565 | |
| GSE38129 | TRPC3 | 7222 | 206425_s_at | 0.0089 | 0.9242 | |
| GSE45670 | TRPC3 | 7222 | 206425_s_at | 0.0541 | 0.4919 | |
| GSE53622 | TRPC3 | 7222 | 114905 | 0.1576 | 0.3626 | |
| GSE53624 | TRPC3 | 7222 | 114905 | 0.1031 | 0.2822 | |
| GSE63941 | TRPC3 | 7222 | 206425_s_at | -0.6208 | 0.0212 | |
| GSE77861 | TRPC3 | 7222 | 206425_s_at | -0.0597 | 0.5655 | |
| GSE97050 | TRPC3 | 7222 | A_23_P41455 | -0.3243 | 0.3472 | |
| SRP064894 | TRPC3 | 7222 | RNAseq | 0.7494 | 0.0195 | |
| SRP133303 | TRPC3 | 7222 | RNAseq | -0.0539 | 0.8128 | |
| SRP159526 | TRPC3 | 7222 | RNAseq | 1.0255 | 0.1964 | |
| SRP193095 | TRPC3 | 7222 | RNAseq | 0.0700 | 0.7438 | |
| SRP219564 | TRPC3 | 7222 | RNAseq | 0.5968 | 0.2980 | |
| TCGA | TRPC3 | 7222 | RNAseq | -1.1031 | 0.0058 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TRPC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TRPC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TRPC3 | 7222 | 1 | 13 | 16 | |
| GSE20123 | TRPC3 | 7222 | 1 | 13 | 16 | |
| GSE43470 | TRPC3 | 7222 | 0 | 13 | 30 | |
| GSE46452 | TRPC3 | 7222 | 1 | 36 | 22 | |
| GSE47630 | TRPC3 | 7222 | 0 | 22 | 18 | |
| GSE54993 | TRPC3 | 7222 | 9 | 0 | 61 | |
| GSE54994 | TRPC3 | 7222 | 1 | 10 | 42 | |
| GSE60625 | TRPC3 | 7222 | 0 | 1 | 10 | |
| GSE74703 | TRPC3 | 7222 | 0 | 11 | 25 | |
| GSE74704 | TRPC3 | 7222 | 0 | 7 | 13 | |
| TCGA | TRPC3 | 7222 | 8 | 34 | 54 |
Total number of gains: 21; Total number of losses: 160; Total Number of normals: 307.
Somatic mutations of TRPC3:
Generating mutation plots.
Highly correlated genes for TRPC3:
Showing top 20/309 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TRPC3 | ZBTB40 | 0.666944 | 4 | 0 | 3 |
| TRPC3 | CSF1 | 0.66082 | 3 | 0 | 3 |
| TRPC3 | FBXW12 | 0.655731 | 4 | 0 | 3 |
| TRPC3 | TECRL | 0.653094 | 3 | 0 | 3 |
| TRPC3 | TCF23 | 0.652839 | 3 | 0 | 3 |
| TRPC3 | KRTAP10-9 | 0.651675 | 3 | 0 | 3 |
| TRPC3 | EPM2A | 0.65045 | 4 | 0 | 4 |
| TRPC3 | NTNG1 | 0.647376 | 5 | 0 | 5 |
| TRPC3 | OR1L6 | 0.641846 | 3 | 0 | 3 |
| TRPC3 | SPOCK2 | 0.641397 | 3 | 0 | 3 |
| TRPC3 | SFTPB | 0.634172 | 4 | 0 | 3 |
| TRPC3 | RORB | 0.63395 | 4 | 0 | 3 |
| TRPC3 | MTAP | 0.633872 | 4 | 0 | 3 |
| TRPC3 | GMPR | 0.63135 | 3 | 0 | 3 |
| TRPC3 | IL1RAPL2 | 0.623517 | 6 | 0 | 5 |
| TRPC3 | PEAK1 | 0.623508 | 6 | 0 | 5 |
| TRPC3 | RIBC1 | 0.623181 | 3 | 0 | 3 |
| TRPC3 | SFTPA2 | 0.618731 | 3 | 0 | 3 |
| TRPC3 | HES6 | 0.618471 | 3 | 0 | 3 |
| TRPC3 | ANXA13 | 0.617028 | 4 | 0 | 4 |
For details and further investigation, click here
