| Full name: EPM2A glucan phosphatase, laforin | Alias Symbol: LDE|LD | ||
| Type: protein-coding gene | Cytoband: 6q24.3 | ||
| Entrez ID: 7957 | HGNC ID: HGNC:3413 | Ensembl Gene: ENSG00000112425 | OMIM ID: 607566 |
| Drug and gene relationship at DGIdb | |||
Expression of EPM2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EPM2A | 7957 | 205231_s_at | -0.7860 | 0.4570 | |
| GSE20347 | EPM2A | 7957 | 216079_at | 0.0022 | 0.9881 | |
| GSE23400 | EPM2A | 7957 | 216079_at | -0.0961 | 0.0031 | |
| GSE26886 | EPM2A | 7957 | 205231_s_at | 0.1687 | 0.4721 | |
| GSE29001 | EPM2A | 7957 | 210870_s_at | 0.2319 | 0.1970 | |
| GSE38129 | EPM2A | 7957 | 205231_s_at | -0.6250 | 0.0291 | |
| GSE45670 | EPM2A | 7957 | 205231_s_at | -1.2363 | 0.0000 | |
| GSE53622 | EPM2A | 7957 | 15976 | -0.7956 | 0.0000 | |
| GSE53624 | EPM2A | 7957 | 15976 | -0.2213 | 0.0035 | |
| GSE63941 | EPM2A | 7957 | 205231_s_at | -0.4373 | 0.3561 | |
| GSE77861 | EPM2A | 7957 | 205231_s_at | -0.0338 | 0.7336 | |
| GSE97050 | EPM2A | 7957 | A_24_P239419 | -0.6937 | 0.3415 | |
| SRP007169 | EPM2A | 7957 | RNAseq | 0.0580 | 0.9442 | |
| SRP064894 | EPM2A | 7957 | RNAseq | -0.6400 | 0.0213 | |
| SRP133303 | EPM2A | 7957 | RNAseq | -0.8321 | 0.0000 | |
| SRP159526 | EPM2A | 7957 | RNAseq | -0.4001 | 0.0924 | |
| SRP193095 | EPM2A | 7957 | RNAseq | -0.1659 | 0.3575 | |
| SRP219564 | EPM2A | 7957 | RNAseq | -1.0383 | 0.2343 | |
| TCGA | EPM2A | 7957 | RNAseq | -0.5875 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by EPM2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EPM2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EPM2A | 7957 | 2 | 4 | 24 | |
| GSE20123 | EPM2A | 7957 | 2 | 3 | 25 | |
| GSE43470 | EPM2A | 7957 | 5 | 0 | 38 | |
| GSE46452 | EPM2A | 7957 | 3 | 11 | 45 | |
| GSE47630 | EPM2A | 7957 | 9 | 4 | 27 | |
| GSE54993 | EPM2A | 7957 | 3 | 2 | 65 | |
| GSE54994 | EPM2A | 7957 | 8 | 8 | 37 | |
| GSE60625 | EPM2A | 7957 | 0 | 1 | 10 | |
| GSE74703 | EPM2A | 7957 | 4 | 0 | 32 | |
| GSE74704 | EPM2A | 7957 | 0 | 1 | 19 | |
| TCGA | EPM2A | 7957 | 12 | 20 | 64 |
Total number of gains: 48; Total number of losses: 54; Total Number of normals: 386.
Somatic mutations of EPM2A:
Generating mutation plots.
Highly correlated genes for EPM2A:
Showing top 20/820 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EPM2A | PLP1 | 0.826743 | 5 | 0 | 5 |
| EPM2A | PCDH9 | 0.774236 | 5 | 0 | 5 |
| EPM2A | TCEAL2 | 0.769637 | 6 | 0 | 5 |
| EPM2A | MITF | 0.764674 | 6 | 0 | 5 |
| EPM2A | INPP5A | 0.764441 | 6 | 0 | 5 |
| EPM2A | RBM24 | 0.763679 | 4 | 0 | 4 |
| EPM2A | ITGA1 | 0.759996 | 5 | 0 | 5 |
| EPM2A | BTC | 0.75954 | 5 | 0 | 5 |
| EPM2A | CCDC69 | 0.752403 | 6 | 0 | 5 |
| EPM2A | SGCA | 0.75117 | 7 | 0 | 7 |
| EPM2A | ADCY5 | 0.750939 | 5 | 0 | 4 |
| EPM2A | FLNC | 0.748252 | 6 | 0 | 5 |
| EPM2A | MFAP5 | 0.744096 | 3 | 0 | 3 |
| EPM2A | FGL2 | 0.742229 | 5 | 0 | 5 |
| EPM2A | RYR2 | 0.738946 | 6 | 0 | 5 |
| EPM2A | CASQ2 | 0.733382 | 6 | 0 | 6 |
| EPM2A | FOXP2 | 0.732247 | 4 | 0 | 3 |
| EPM2A | ANKS1A | 0.730365 | 5 | 0 | 4 |
| EPM2A | NCAM1 | 0.727479 | 7 | 0 | 6 |
| EPM2A | MYOCD | 0.725886 | 6 | 0 | 6 |
For details and further investigation, click here
