| Full name: colony stimulating factor 1 | Alias Symbol: M-CSF|MCSF|MGC31930 | ||
| Type: protein-coding gene | Cytoband: 1p13.3 | ||
| Entrez ID: 1435 | HGNC ID: HGNC:2432 | Ensembl Gene: ENSG00000184371 | OMIM ID: 120420 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CSF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04015 | Rap1 signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04380 | Osteoclast differentiation |
Expression of CSF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSF1 | 1435 | 209716_at | -0.2048 | 0.6144 | |
| GSE20347 | CSF1 | 1435 | 209716_at | -0.0076 | 0.9293 | |
| GSE23400 | CSF1 | 1435 | 207082_at | -0.0465 | 0.3064 | |
| GSE26886 | CSF1 | 1435 | 209716_at | 0.3754 | 0.0731 | |
| GSE29001 | CSF1 | 1435 | 209716_at | 0.2503 | 0.3336 | |
| GSE38129 | CSF1 | 1435 | 209716_at | -0.2681 | 0.0175 | |
| GSE45670 | CSF1 | 1435 | 209716_at | -0.1331 | 0.2996 | |
| GSE53622 | CSF1 | 1435 | 19819 | -0.0892 | 0.4982 | |
| GSE53624 | CSF1 | 1435 | 19819 | 0.0818 | 0.4907 | |
| GSE63941 | CSF1 | 1435 | 209716_at | -2.6211 | 0.0001 | |
| GSE77861 | CSF1 | 1435 | 209716_at | 0.0767 | 0.5106 | |
| GSE97050 | CSF1 | 1435 | A_33_P3354945 | 0.1673 | 0.6369 | |
| SRP007169 | CSF1 | 1435 | RNAseq | 1.6962 | 0.0135 | |
| SRP008496 | CSF1 | 1435 | RNAseq | 1.1665 | 0.0125 | |
| SRP064894 | CSF1 | 1435 | RNAseq | 0.2966 | 0.2141 | |
| SRP133303 | CSF1 | 1435 | RNAseq | -0.0972 | 0.6493 | |
| SRP159526 | CSF1 | 1435 | RNAseq | -0.2536 | 0.2753 | |
| SRP193095 | CSF1 | 1435 | RNAseq | 0.8202 | 0.0000 | |
| SRP219564 | CSF1 | 1435 | RNAseq | 0.5411 | 0.3522 | |
| TCGA | CSF1 | 1435 | RNAseq | -0.1022 | 0.3003 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by CSF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSF1 | 1435 | 0 | 12 | 18 | |
| GSE20123 | CSF1 | 1435 | 0 | 11 | 19 | |
| GSE43470 | CSF1 | 1435 | 0 | 9 | 34 | |
| GSE46452 | CSF1 | 1435 | 2 | 1 | 56 | |
| GSE47630 | CSF1 | 1435 | 9 | 5 | 26 | |
| GSE54993 | CSF1 | 1435 | 0 | 1 | 69 | |
| GSE54994 | CSF1 | 1435 | 7 | 4 | 42 | |
| GSE60625 | CSF1 | 1435 | 0 | 0 | 11 | |
| GSE74703 | CSF1 | 1435 | 0 | 7 | 29 | |
| GSE74704 | CSF1 | 1435 | 0 | 7 | 13 | |
| TCGA | CSF1 | 1435 | 9 | 26 | 61 |
Total number of gains: 27; Total number of losses: 83; Total Number of normals: 378.
Somatic mutations of CSF1:
Generating mutation plots.
Highly correlated genes for CSF1:
Showing top 20/847 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSF1 | TK2 | 0.776857 | 3 | 0 | 3 |
| CSF1 | C1orf68 | 0.760941 | 3 | 0 | 3 |
| CSF1 | ARHGAP17 | 0.74803 | 3 | 0 | 3 |
| CSF1 | ZNF540 | 0.741566 | 3 | 0 | 3 |
| CSF1 | FANCC | 0.736782 | 3 | 0 | 3 |
| CSF1 | MARCKSL1 | 0.735339 | 3 | 0 | 3 |
| CSF1 | IL5RA | 0.728853 | 3 | 0 | 3 |
| CSF1 | KRTCAP2 | 0.719899 | 3 | 0 | 3 |
| CSF1 | COPS7A | 0.718501 | 3 | 0 | 3 |
| CSF1 | TNFSF12 | 0.712563 | 3 | 0 | 3 |
| CSF1 | SETD7 | 0.711523 | 3 | 0 | 3 |
| CSF1 | C22orf31 | 0.710206 | 3 | 0 | 3 |
| CSF1 | PEG3 | 0.709908 | 4 | 0 | 4 |
| CSF1 | DISC1 | 0.704488 | 3 | 0 | 3 |
| CSF1 | IMPAD1 | 0.704284 | 3 | 0 | 3 |
| CSF1 | BAZ1B | 0.7036 | 3 | 0 | 3 |
| CSF1 | TAPBP | 0.702018 | 5 | 0 | 5 |
| CSF1 | MSL3 | 0.695684 | 3 | 0 | 3 |
| CSF1 | PRNP | 0.693411 | 3 | 0 | 3 |
| CSF1 | SH3RF3 | 0.693251 | 4 | 0 | 4 |
For details and further investigation, click here
