| Full name: N-acetyl-alpha-glucosaminidase | Alias Symbol: NAG | ||
| Type: protein-coding gene | Cytoband: 17q21.2 | ||
| Entrez ID: 4669 | HGNC ID: HGNC:7632 | Ensembl Gene: ENSG00000108784 | OMIM ID: 609701 |
| Drug and gene relationship at DGIdb | |||
Expression of NAGLU:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NAGLU | 4669 | 204360_s_at | 0.0138 | 0.9779 | |
| GSE20347 | NAGLU | 4669 | 204360_s_at | 0.0401 | 0.7694 | |
| GSE23400 | NAGLU | 4669 | 204360_s_at | 0.0621 | 0.1600 | |
| GSE26886 | NAGLU | 4669 | 204360_s_at | 0.4951 | 0.0176 | |
| GSE29001 | NAGLU | 4669 | 215880_at | -0.0436 | 0.8231 | |
| GSE38129 | NAGLU | 4669 | 204360_s_at | 0.0795 | 0.4832 | |
| GSE45670 | NAGLU | 4669 | 204360_s_at | 0.0213 | 0.8622 | |
| GSE53622 | NAGLU | 4669 | 78421 | 0.3286 | 0.0001 | |
| GSE53624 | NAGLU | 4669 | 78421 | 0.3472 | 0.0000 | |
| GSE63941 | NAGLU | 4669 | 204360_s_at | -1.6132 | 0.0001 | |
| GSE77861 | NAGLU | 4669 | 204360_s_at | 0.0791 | 0.6231 | |
| GSE97050 | NAGLU | 4669 | A_23_P26945 | 0.2583 | 0.3445 | |
| SRP007169 | NAGLU | 4669 | RNAseq | 0.4272 | 0.3090 | |
| SRP008496 | NAGLU | 4669 | RNAseq | 0.4442 | 0.1454 | |
| SRP064894 | NAGLU | 4669 | RNAseq | 0.6968 | 0.0105 | |
| SRP133303 | NAGLU | 4669 | RNAseq | 0.0679 | 0.6799 | |
| SRP159526 | NAGLU | 4669 | RNAseq | 0.2557 | 0.2945 | |
| SRP193095 | NAGLU | 4669 | RNAseq | 0.1520 | 0.3054 | |
| SRP219564 | NAGLU | 4669 | RNAseq | 0.6157 | 0.0082 | |
| TCGA | NAGLU | 4669 | RNAseq | -0.1817 | 0.0003 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by NAGLU expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NAGLU:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NAGLU | 4669 | 6 | 2 | 22 | |
| GSE20123 | NAGLU | 4669 | 6 | 2 | 22 | |
| GSE43470 | NAGLU | 4669 | 1 | 2 | 40 | |
| GSE46452 | NAGLU | 4669 | 34 | 0 | 25 | |
| GSE47630 | NAGLU | 4669 | 8 | 1 | 31 | |
| GSE54993 | NAGLU | 4669 | 3 | 4 | 63 | |
| GSE54994 | NAGLU | 4669 | 8 | 5 | 40 | |
| GSE60625 | NAGLU | 4669 | 4 | 0 | 7 | |
| GSE74703 | NAGLU | 4669 | 1 | 1 | 34 | |
| GSE74704 | NAGLU | 4669 | 4 | 1 | 15 | |
| TCGA | NAGLU | 4669 | 23 | 6 | 67 |
Total number of gains: 98; Total number of losses: 24; Total Number of normals: 366.
Somatic mutations of NAGLU:
Generating mutation plots.
Highly correlated genes for NAGLU:
Showing top 20/529 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NAGLU | DRAM2 | 0.781011 | 3 | 0 | 3 |
| NAGLU | LZTS1 | 0.772678 | 4 | 0 | 4 |
| NAGLU | TRIB2 | 0.759155 | 4 | 0 | 4 |
| NAGLU | CALCRL | 0.756164 | 3 | 0 | 3 |
| NAGLU | PVRIG | 0.744066 | 3 | 0 | 3 |
| NAGLU | CXCR5 | 0.742956 | 4 | 0 | 4 |
| NAGLU | ZNF771 | 0.739035 | 3 | 0 | 3 |
| NAGLU | TNFRSF19 | 0.738244 | 3 | 0 | 3 |
| NAGLU | MIER2 | 0.737138 | 3 | 0 | 3 |
| NAGLU | KTI12 | 0.729652 | 3 | 0 | 3 |
| NAGLU | DNALI1 | 0.727063 | 3 | 0 | 3 |
| NAGLU | LGI2 | 0.723727 | 3 | 0 | 3 |
| NAGLU | ARHGAP24 | 0.721045 | 4 | 0 | 4 |
| NAGLU | RABEP2 | 0.719707 | 3 | 0 | 3 |
| NAGLU | CD53 | 0.708504 | 3 | 0 | 3 |
| NAGLU | ADCYAP1 | 0.706093 | 3 | 0 | 3 |
| NAGLU | CD19 | 0.705926 | 3 | 0 | 3 |
| NAGLU | TGFB2 | 0.704143 | 3 | 0 | 3 |
| NAGLU | SSH2 | 0.700088 | 4 | 0 | 4 |
| NAGLU | NOL6 | 0.699761 | 3 | 0 | 3 |
For details and further investigation, click here
