| Full name: tetratricopeptide repeat domain 3 | Alias Symbol: TPRD|TPRDI|DCRR1|TPRDII|TPRDIII|RNF105 | ||
| Type: protein-coding gene | Cytoband: 21q22.13 | ||
| Entrez ID: 7267 | HGNC ID: HGNC:12393 | Ensembl Gene: ENSG00000182670 | OMIM ID: 602259 |
| Drug and gene relationship at DGIdb | |||
Expression of TTC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | TTC3 | 7267 | 21581 | -0.0317 | 0.6803 | |
| GSE53624 | TTC3 | 7267 | 21581 | 0.0205 | 0.8230 | |
| GSE97050 | TTC3 | 7267 | A_23_P120710 | 0.0226 | 0.9369 | |
| SRP007169 | TTC3 | 7267 | RNAseq | 0.8506 | 0.0089 | |
| SRP008496 | TTC3 | 7267 | RNAseq | 1.2410 | 0.0000 | |
| SRP064894 | TTC3 | 7267 | RNAseq | 0.2743 | 0.1041 | |
| SRP133303 | TTC3 | 7267 | RNAseq | -0.0845 | 0.6376 | |
| SRP159526 | TTC3 | 7267 | RNAseq | 0.0281 | 0.8812 | |
| SRP193095 | TTC3 | 7267 | RNAseq | -0.1378 | 0.1969 | |
| SRP219564 | TTC3 | 7267 | RNAseq | -0.1208 | 0.6521 | |
| TCGA | TTC3 | 7267 | RNAseq | -0.2344 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by TTC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC3 | 7267 | 2 | 8 | 20 | |
| GSE20123 | TTC3 | 7267 | 2 | 9 | 19 | |
| GSE43470 | TTC3 | 7267 | 1 | 10 | 32 | |
| GSE46452 | TTC3 | 7267 | 1 | 21 | 37 | |
| GSE47630 | TTC3 | 7267 | 6 | 17 | 17 | |
| GSE54993 | TTC3 | 7267 | 8 | 1 | 61 | |
| GSE54994 | TTC3 | 7267 | 2 | 9 | 42 | |
| GSE60625 | TTC3 | 7267 | 0 | 0 | 11 | |
| GSE74703 | TTC3 | 7267 | 1 | 7 | 28 | |
| GSE74704 | TTC3 | 7267 | 1 | 6 | 13 | |
| TCGA | TTC3 | 7267 | 8 | 40 | 48 |
Total number of gains: 32; Total number of losses: 128; Total Number of normals: 328.
Somatic mutations of TTC3:
Generating mutation plots.
Highly correlated genes for TTC3:
Showing top 20/33 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC3 | FAM13A | 0.725667 | 3 | 0 | 3 |
| TTC3 | ZNF70 | 0.718612 | 3 | 0 | 3 |
| TTC3 | ABI2 | 0.711039 | 3 | 0 | 3 |
| TTC3 | ZNF512 | 0.704949 | 3 | 0 | 3 |
| TTC3 | MRAS | 0.702886 | 3 | 0 | 3 |
| TTC3 | VPS13C | 0.70033 | 3 | 0 | 3 |
| TTC3 | ARMCX3 | 0.700202 | 3 | 0 | 3 |
| TTC3 | SMURF2 | 0.697791 | 3 | 0 | 3 |
| TTC3 | PBXIP1 | 0.696956 | 3 | 0 | 3 |
| TTC3 | RFXAP | 0.696635 | 3 | 0 | 3 |
| TTC3 | ERLEC1 | 0.691571 | 3 | 0 | 3 |
| TTC3 | CD164 | 0.68895 | 3 | 0 | 3 |
| TTC3 | PHYH | 0.688806 | 3 | 0 | 3 |
| TTC3 | MAGEH1 | 0.683343 | 3 | 0 | 3 |
| TTC3 | PCDH18 | 0.681331 | 3 | 0 | 3 |
| TTC3 | FRZB | 0.668766 | 3 | 0 | 3 |
| TTC3 | ARMCX2 | 0.66732 | 3 | 0 | 3 |
| TTC3 | TXNDC16 | 0.662226 | 3 | 0 | 3 |
| TTC3 | CTSO | 0.658169 | 3 | 0 | 3 |
| TTC3 | SGCB | 0.647738 | 3 | 0 | 3 |
For details and further investigation, click here
