| Full name: ADP ribosylation factor 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q21.3 | ||
| Entrez ID: 382 | HGNC ID: HGNC:659 | Ensembl Gene: ENSG00000165527 | OMIM ID: 600464 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
ARF6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04014 | Ras signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04666 | Fc gamma R-mediated phagocytosis |
Expression of ARF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARF6 | 382 | 224788_at | 0.0005 | 0.9995 | |
| GSE20347 | ARF6 | 382 | 203312_x_at | -0.8080 | 0.0000 | |
| GSE23400 | ARF6 | 382 | 203312_x_at | -0.5178 | 0.0000 | |
| GSE26886 | ARF6 | 382 | 224788_at | -1.1387 | 0.0000 | |
| GSE29001 | ARF6 | 382 | 203312_x_at | -0.5102 | 0.0137 | |
| GSE38129 | ARF6 | 382 | 203312_x_at | -0.5608 | 0.0140 | |
| GSE45670 | ARF6 | 382 | 224788_at | -0.2021 | 0.0982 | |
| GSE53622 | ARF6 | 382 | 40051 | -0.9785 | 0.0000 | |
| GSE53624 | ARF6 | 382 | 40051 | -1.1678 | 0.0000 | |
| GSE63941 | ARF6 | 382 | 224788_at | -0.3298 | 0.2753 | |
| GSE77861 | ARF6 | 382 | 224788_at | -0.7879 | 0.0116 | |
| GSE97050 | ARF6 | 382 | A_24_P472455 | -0.0635 | 0.8789 | |
| SRP007169 | ARF6 | 382 | RNAseq | -2.4638 | 0.0000 | |
| SRP008496 | ARF6 | 382 | RNAseq | -2.4279 | 0.0000 | |
| SRP064894 | ARF6 | 382 | RNAseq | -1.2935 | 0.0000 | |
| SRP133303 | ARF6 | 382 | RNAseq | -0.7781 | 0.0001 | |
| SRP159526 | ARF6 | 382 | RNAseq | -1.5674 | 0.0000 | |
| SRP193095 | ARF6 | 382 | RNAseq | -1.2088 | 0.0000 | |
| SRP219564 | ARF6 | 382 | RNAseq | -1.0575 | 0.0673 | |
| TCGA | ARF6 | 382 | RNAseq | 0.0807 | 0.1026 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by ARF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARF6 | 382 | 8 | 2 | 20 | |
| GSE20123 | ARF6 | 382 | 8 | 3 | 19 | |
| GSE43470 | ARF6 | 382 | 7 | 1 | 35 | |
| GSE46452 | ARF6 | 382 | 16 | 3 | 40 | |
| GSE47630 | ARF6 | 382 | 11 | 10 | 19 | |
| GSE54993 | ARF6 | 382 | 3 | 9 | 58 | |
| GSE54994 | ARF6 | 382 | 19 | 4 | 30 | |
| GSE60625 | ARF6 | 382 | 0 | 2 | 9 | |
| GSE74703 | ARF6 | 382 | 6 | 1 | 29 | |
| GSE74704 | ARF6 | 382 | 3 | 2 | 15 | |
| TCGA | ARF6 | 382 | 34 | 13 | 49 |
Total number of gains: 115; Total number of losses: 50; Total Number of normals: 323.
Somatic mutations of ARF6:
Generating mutation plots.
Highly correlated genes for ARF6:
Showing top 20/1769 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARF6 | TLE4 | 0.792244 | 3 | 0 | 3 |
| ARF6 | FCHO2 | 0.786067 | 6 | 0 | 6 |
| ARF6 | SLC16A6 | 0.780032 | 10 | 0 | 10 |
| ARF6 | A2ML1 | 0.776075 | 5 | 0 | 5 |
| ARF6 | NAGK | 0.77165 | 9 | 0 | 9 |
| ARF6 | CA13 | 0.769964 | 3 | 0 | 3 |
| ARF6 | FRMD4B | 0.769529 | 11 | 0 | 11 |
| ARF6 | WDFY1 | 0.768167 | 4 | 0 | 4 |
| ARF6 | SLK | 0.764247 | 11 | 0 | 11 |
| ARF6 | ZNF185 | 0.763891 | 9 | 0 | 9 |
| ARF6 | PGM2 | 0.763487 | 6 | 0 | 6 |
| ARF6 | SNORA68 | 0.763424 | 3 | 0 | 3 |
| ARF6 | GSKIP | 0.762708 | 6 | 0 | 6 |
| ARF6 | GDPD3 | 0.761521 | 9 | 0 | 9 |
| ARF6 | CAPNS2 | 0.760405 | 4 | 0 | 4 |
| ARF6 | C6orf132 | 0.76019 | 6 | 0 | 6 |
| ARF6 | ENDOU | 0.759472 | 10 | 0 | 10 |
| ARF6 | CYSRT1 | 0.758964 | 5 | 0 | 5 |
| ARF6 | TOM1 | 0.754864 | 10 | 0 | 10 |
| ARF6 | RASSF5 | 0.754445 | 7 | 0 | 7 |
For details and further investigation, click here
