CUL3

 

Full name: cullin 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 2q36.2
Entrez ID: 8452 HGNC ID: HGNC:2553 Ensembl Gene: ENSG00000036257 OMIM ID: 603136
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 222/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CUL3 involved pathways:

KEGG pathway Description View
hsa04340Hedgehog signaling pathway

 

Expression of CUL3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CUL3 8452 201371_s_at -0.5743 0.2434
GSE20347 CUL3 8452 201371_s_at -0.9141 0.0000
GSE23400 CUL3 8452 201371_s_at -0.9094 0.0000
GSE26886 CUL3 8452 201371_s_at -1.0703 0.0000
GSE29001 CUL3 8452 201371_s_at -0.8412 0.0104
GSE38129 CUL3 8452 201371_s_at -0.6358 0.0000
GSE45670 CUL3 8452 201371_s_at -0.4934 0.0158
GSE53622 CUL3 8452 132529 -0.8056 0.0000
GSE53624 CUL3 8452 132529 -1.0251 0.0000
GSE63941 CUL3 8452 201371_s_at -0.6553 0.0445
GSE77861 CUL3 8452 201371_s_at -0.4795 0.1396
GSE97050 CUL3 8452 A_33_P3321150 -0.1917 0.4406
SRP007169 CUL3 8452 RNAseq -1.3748 0.0001
SRP008496 CUL3 8452 RNAseq -1.3082 0.0000
SRP064894 CUL3 8452 RNAseq -1.2888 0.0000
SRP133303 CUL3 8452 RNAseq -0.5929 0.0000
SRP159526 CUL3 8452 RNAseq -1.2202 0.0000
SRP193095 CUL3 8452 RNAseq -1.0377 0.0000
SRP219564 CUL3 8452 RNAseq -1.2825 0.0000
TCGA CUL3 8452 RNAseq -0.0965 0.0344

Upregulated datasets: 0; Downregulated datasets: 8.  

 

Survival by CUL3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CUL3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CUL3 8452 2 12 16
GSE20123 CUL3 8452 2 12 16
GSE43470 CUL3 8452 0 8 35
GSE46452 CUL3 8452 0 5 54
GSE47630 CUL3 8452 4 5 31
GSE54993 CUL3 8452 1 2 67
GSE54994 CUL3 8452 6 10 37
GSE60625 CUL3 8452 3 0 8
GSE74703 CUL3 8452 0 7 29
GSE74704 CUL3 8452 2 6 12
TCGA CUL3 8452 13 27 56

Total number of gains: 33; Total number of losses: 94; Total Number of normals: 361.  

 

Somatic mutations of CUL3:

 

Generating mutation plots.

 

Highly correlated genes for CUL3:

 

Showing top 20/1688 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CUL3RMND5B0.80584111011
CUL3UBL30.80534610010
CUL3CCDC70.802629303
CUL3RBM200.796865404
CUL3KRT780.793725606
CUL3CA130.790907303
CUL3RNF1410.79021511011
CUL3NAGK0.78835911011
CUL3TMOD30.7858110010
CUL3VSIG20.78385606
CUL3CASC30.783119303
CUL3TBC1D230.782534303
CUL3PAIP20.781505303
CUL3ACPP0.7814310010
CUL3SMIM50.779738606
CUL3FAM3D0.77851606
CUL3USP6NL0.7777111011
CUL3CHP10.77705510010
CUL3CAPN140.776971606
CUL3CCNG20.7729511011

For details and further investigation, click here