| Full name: SEC31 homolog A, COPII coat complex component | Alias Symbol: KIAA0905|ABP125|ABP130 | ||
| Type: protein-coding gene | Cytoband: 4q21.22 | ||
| Entrez ID: 22872 | HGNC ID: HGNC:17052 | Ensembl Gene: ENSG00000138674 | OMIM ID: 610257 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SEC31A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC31A | 22872 | 200945_s_at | -0.0168 | 0.9635 | |
| GSE20347 | SEC31A | 22872 | 200945_s_at | -0.2872 | 0.0063 | |
| GSE23400 | SEC31A | 22872 | 200945_s_at | -0.1093 | 0.0711 | |
| GSE26886 | SEC31A | 22872 | 200945_s_at | 0.2031 | 0.4350 | |
| GSE29001 | SEC31A | 22872 | 200945_s_at | -0.4123 | 0.0933 | |
| GSE38129 | SEC31A | 22872 | 200945_s_at | -0.2905 | 0.0004 | |
| GSE45670 | SEC31A | 22872 | 210616_s_at | -0.3963 | 0.0023 | |
| GSE53622 | SEC31A | 22872 | 101221 | -0.0298 | 0.6133 | |
| GSE53624 | SEC31A | 22872 | 101221 | -0.0648 | 0.4030 | |
| GSE63941 | SEC31A | 22872 | 200945_s_at | -1.5502 | 0.0012 | |
| GSE77861 | SEC31A | 22872 | 200945_s_at | -0.4392 | 0.0414 | |
| GSE97050 | SEC31A | 22872 | A_24_P277349 | 0.2621 | 0.3130 | |
| SRP007169 | SEC31A | 22872 | RNAseq | -0.6094 | 0.0498 | |
| SRP008496 | SEC31A | 22872 | RNAseq | -0.6201 | 0.0002 | |
| SRP064894 | SEC31A | 22872 | RNAseq | -0.1897 | 0.2754 | |
| SRP133303 | SEC31A | 22872 | RNAseq | 0.1107 | 0.6259 | |
| SRP159526 | SEC31A | 22872 | RNAseq | -0.4670 | 0.0377 | |
| SRP193095 | SEC31A | 22872 | RNAseq | -0.2755 | 0.0064 | |
| SRP219564 | SEC31A | 22872 | RNAseq | 0.0587 | 0.8234 | |
| TCGA | SEC31A | 22872 | RNAseq | -0.0796 | 0.0367 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SEC31A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC31A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC31A | 22872 | 2 | 11 | 17 | |
| GSE20123 | SEC31A | 22872 | 2 | 11 | 17 | |
| GSE43470 | SEC31A | 22872 | 0 | 13 | 30 | |
| GSE46452 | SEC31A | 22872 | 1 | 36 | 22 | |
| GSE47630 | SEC31A | 22872 | 0 | 20 | 20 | |
| GSE54993 | SEC31A | 22872 | 8 | 0 | 62 | |
| GSE54994 | SEC31A | 22872 | 1 | 9 | 43 | |
| GSE60625 | SEC31A | 22872 | 0 | 0 | 11 | |
| GSE74703 | SEC31A | 22872 | 0 | 11 | 25 | |
| GSE74704 | SEC31A | 22872 | 1 | 6 | 13 | |
| TCGA | SEC31A | 22872 | 12 | 34 | 50 |
Total number of gains: 27; Total number of losses: 151; Total Number of normals: 310.
Somatic mutations of SEC31A:
Generating mutation plots.
Highly correlated genes for SEC31A:
Showing top 20/535 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC31A | TTLL3 | 0.733113 | 3 | 0 | 3 |
| SEC31A | SMARCA4 | 0.715338 | 3 | 0 | 3 |
| SEC31A | ZNF16 | 0.714473 | 3 | 0 | 3 |
| SEC31A | MAML2 | 0.676996 | 4 | 0 | 4 |
| SEC31A | FNIP2 | 0.673393 | 3 | 0 | 3 |
| SEC31A | EI24 | 0.672281 | 3 | 0 | 3 |
| SEC31A | HSPA4 | 0.669546 | 3 | 0 | 3 |
| SEC31A | KCND1 | 0.668163 | 3 | 0 | 3 |
| SEC31A | CYFIP1 | 0.665904 | 4 | 0 | 4 |
| SEC31A | TSNARE1 | 0.665338 | 3 | 0 | 3 |
| SEC31A | ATMIN | 0.656304 | 5 | 0 | 4 |
| SEC31A | VSIG2 | 0.654847 | 3 | 0 | 3 |
| SEC31A | EIF4G3 | 0.654103 | 4 | 0 | 4 |
| SEC31A | ERGIC1 | 0.653658 | 3 | 0 | 3 |
| SEC31A | TNRC6A | 0.653142 | 3 | 0 | 3 |
| SEC31A | DOK6 | 0.649199 | 3 | 0 | 3 |
| SEC31A | ANKRD35 | 0.647892 | 3 | 0 | 3 |
| SEC31A | TEAD1 | 0.64616 | 6 | 0 | 5 |
| SEC31A | FNBP1 | 0.643336 | 5 | 0 | 4 |
| SEC31A | TMEM234 | 0.641119 | 5 | 0 | 4 |
For details and further investigation, click here
