| Full name: twisted gastrulation BMP signaling modulator 1 | Alias Symbol: TSG | ||
| Type: protein-coding gene | Cytoband: 18p11.22 | ||
| Entrez ID: 57045 | HGNC ID: HGNC:12429 | Ensembl Gene: ENSG00000128791 | OMIM ID: 605049 |
| Drug and gene relationship at DGIdb | |||
Expression of TWSG1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TWSG1 | 57045 | 225406_at | -0.0148 | 0.9899 | |
| GSE20347 | TWSG1 | 57045 | 219201_s_at | 0.9805 | 0.0000 | |
| GSE23400 | TWSG1 | 57045 | 219201_s_at | 0.3271 | 0.0004 | |
| GSE26886 | TWSG1 | 57045 | 225406_at | 0.9882 | 0.0014 | |
| GSE29001 | TWSG1 | 57045 | 219201_s_at | 0.9088 | 0.0353 | |
| GSE38129 | TWSG1 | 57045 | 219201_s_at | 0.8840 | 0.0001 | |
| GSE45670 | TWSG1 | 57045 | 225406_at | -0.2878 | 0.1617 | |
| GSE53622 | TWSG1 | 57045 | 89675 | 0.4299 | 0.0001 | |
| GSE53624 | TWSG1 | 57045 | 89675 | 0.6242 | 0.0000 | |
| GSE63941 | TWSG1 | 57045 | 225406_at | -2.7008 | 0.0021 | |
| GSE77861 | TWSG1 | 57045 | 225406_at | 1.0411 | 0.0111 | |
| GSE97050 | TWSG1 | 57045 | A_24_P202497 | -0.1405 | 0.7101 | |
| SRP007169 | TWSG1 | 57045 | RNAseq | 1.3911 | 0.0006 | |
| SRP008496 | TWSG1 | 57045 | RNAseq | 1.7650 | 0.0000 | |
| SRP064894 | TWSG1 | 57045 | RNAseq | 0.5706 | 0.0293 | |
| SRP133303 | TWSG1 | 57045 | RNAseq | 1.0269 | 0.0000 | |
| SRP159526 | TWSG1 | 57045 | RNAseq | 0.8375 | 0.0027 | |
| SRP193095 | TWSG1 | 57045 | RNAseq | 0.9656 | 0.0000 | |
| SRP219564 | TWSG1 | 57045 | RNAseq | 0.1642 | 0.7605 | |
| TCGA | TWSG1 | 57045 | RNAseq | 0.0167 | 0.7906 |
Upregulated datasets: 4; Downregulated datasets: 1.
Survival by TWSG1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TWSG1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TWSG1 | 57045 | 6 | 3 | 21 | |
| GSE20123 | TWSG1 | 57045 | 6 | 3 | 21 | |
| GSE43470 | TWSG1 | 57045 | 3 | 6 | 34 | |
| GSE46452 | TWSG1 | 57045 | 3 | 21 | 35 | |
| GSE47630 | TWSG1 | 57045 | 7 | 17 | 16 | |
| GSE54993 | TWSG1 | 57045 | 6 | 3 | 61 | |
| GSE54994 | TWSG1 | 57045 | 8 | 8 | 37 | |
| GSE60625 | TWSG1 | 57045 | 0 | 4 | 7 | |
| GSE74703 | TWSG1 | 57045 | 2 | 4 | 30 | |
| GSE74704 | TWSG1 | 57045 | 4 | 2 | 14 | |
| TCGA | TWSG1 | 57045 | 29 | 23 | 44 |
Total number of gains: 74; Total number of losses: 94; Total Number of normals: 320.
Somatic mutations of TWSG1:
Generating mutation plots.
Highly correlated genes for TWSG1:
Showing top 20/1180 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TWSG1 | ALKBH6 | 0.789403 | 3 | 0 | 3 |
| TWSG1 | CCDC51 | 0.782412 | 3 | 0 | 3 |
| TWSG1 | TBC1D8B | 0.775669 | 3 | 0 | 3 |
| TWSG1 | EP400 | 0.766769 | 3 | 0 | 3 |
| TWSG1 | LTBR | 0.764943 | 3 | 0 | 3 |
| TWSG1 | ATL1 | 0.753378 | 3 | 0 | 3 |
| TWSG1 | UAP1L1 | 0.747248 | 3 | 0 | 3 |
| TWSG1 | B3GALNT2 | 0.734168 | 3 | 0 | 3 |
| TWSG1 | CLN5 | 0.73408 | 4 | 0 | 3 |
| TWSG1 | AFAP1L2 | 0.733893 | 3 | 0 | 3 |
| TWSG1 | GGNBP2 | 0.727559 | 3 | 0 | 3 |
| TWSG1 | IDS | 0.719229 | 4 | 0 | 4 |
| TWSG1 | TMEM60 | 0.717184 | 4 | 0 | 4 |
| TWSG1 | SLC16A2 | 0.71068 | 4 | 0 | 3 |
| TWSG1 | USP40 | 0.706896 | 3 | 0 | 3 |
| TWSG1 | TMEM92 | 0.705738 | 3 | 0 | 3 |
| TWSG1 | COPB1 | 0.704154 | 3 | 0 | 3 |
| TWSG1 | TMEM263 | 0.700247 | 6 | 0 | 6 |
| TWSG1 | PPP1R21 | 0.698964 | 5 | 0 | 5 |
| TWSG1 | LAMC1 | 0.698255 | 12 | 0 | 12 |
For details and further investigation, click here
