| Full name: protein phosphatase 1 regulatory subunit 21 | Alias Symbol: FLJ16566 | ||
| Type: protein-coding gene | Cytoband: 2p16.3 | ||
| Entrez ID: 129285 | HGNC ID: HGNC:30595 | Ensembl Gene: ENSG00000162869 | OMIM ID: 618159 |
| Drug and gene relationship at DGIdb | |||
Expression of PPP1R21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R21 | 129285 | 1553955_at | -0.0868 | 0.8699 | |
| GSE26886 | PPP1R21 | 129285 | 1553955_at | -0.0262 | 0.8950 | |
| GSE45670 | PPP1R21 | 129285 | 1553955_at | -0.1474 | 0.3919 | |
| GSE53622 | PPP1R21 | 129285 | 8409 | 0.1095 | 0.1419 | |
| GSE53624 | PPP1R21 | 129285 | 78651 | -0.1883 | 0.0005 | |
| GSE63941 | PPP1R21 | 129285 | 1553955_at | -0.5979 | 0.1910 | |
| GSE77861 | PPP1R21 | 129285 | 1553955_at | 0.3137 | 0.2270 | |
| GSE97050 | PPP1R21 | 129285 | A_23_P90895 | -0.0568 | 0.8657 | |
| SRP007169 | PPP1R21 | 129285 | RNAseq | -0.2314 | 0.6033 | |
| SRP008496 | PPP1R21 | 129285 | RNAseq | 0.0499 | 0.8602 | |
| SRP064894 | PPP1R21 | 129285 | RNAseq | -0.0855 | 0.6587 | |
| SRP133303 | PPP1R21 | 129285 | RNAseq | -0.0928 | 0.5733 | |
| SRP159526 | PPP1R21 | 129285 | RNAseq | 0.0156 | 0.9483 | |
| SRP193095 | PPP1R21 | 129285 | RNAseq | 0.0155 | 0.8889 | |
| SRP219564 | PPP1R21 | 129285 | RNAseq | -0.3149 | 0.3333 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R21 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of PPP1R21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R21 | 129285 | 8 | 1 | 21 | |
| GSE20123 | PPP1R21 | 129285 | 7 | 1 | 22 | |
| GSE43470 | PPP1R21 | 129285 | 5 | 0 | 38 | |
| GSE46452 | PPP1R21 | 129285 | 1 | 4 | 54 | |
| GSE47630 | PPP1R21 | 129285 | 8 | 0 | 32 | |
| GSE54993 | PPP1R21 | 129285 | 0 | 5 | 65 | |
| GSE54994 | PPP1R21 | 129285 | 12 | 0 | 41 | |
| GSE60625 | PPP1R21 | 129285 | 0 | 3 | 8 | |
| GSE74703 | PPP1R21 | 129285 | 5 | 0 | 31 | |
| GSE74704 | PPP1R21 | 129285 | 8 | 1 | 11 | |
| TCGA | PPP1R21 | 129285 | 36 | 2 | 58 |
Total number of gains: 90; Total number of losses: 17; Total Number of normals: 381.
Somatic mutations of PPP1R21:
Generating mutation plots.
Highly correlated genes for PPP1R21:
Showing top 20/167 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R21 | SEC23A | 0.79923 | 3 | 0 | 3 |
| PPP1R21 | STK17A | 0.796069 | 3 | 0 | 3 |
| PPP1R21 | XPO4 | 0.775039 | 3 | 0 | 3 |
| PPP1R21 | CHD1 | 0.753191 | 3 | 0 | 3 |
| PPP1R21 | MRPL32 | 0.751779 | 3 | 0 | 3 |
| PPP1R21 | USP40 | 0.743275 | 3 | 0 | 3 |
| PPP1R21 | F2RL1 | 0.740885 | 3 | 0 | 3 |
| PPP1R21 | LMNA | 0.739378 | 3 | 0 | 3 |
| PPP1R21 | TGFBR1 | 0.739365 | 3 | 0 | 3 |
| PPP1R21 | SCRN1 | 0.737597 | 3 | 0 | 3 |
| PPP1R21 | ASPH | 0.735369 | 3 | 0 | 3 |
| PPP1R21 | RP9 | 0.730992 | 3 | 0 | 3 |
| PPP1R21 | CREB5 | 0.728296 | 3 | 0 | 3 |
| PPP1R21 | NEK7 | 0.726582 | 4 | 0 | 4 |
| PPP1R21 | SKA2 | 0.726004 | 3 | 0 | 3 |
| PPP1R21 | ERVW-1 | 0.724259 | 3 | 0 | 3 |
| PPP1R21 | CAV2 | 0.721796 | 4 | 0 | 3 |
| PPP1R21 | ZC3H14 | 0.721293 | 4 | 0 | 3 |
| PPP1R21 | ACVR1 | 0.719013 | 3 | 0 | 3 |
| PPP1R21 | CWF19L2 | 0.714939 | 3 | 0 | 3 |
For details and further investigation, click here
