| Full name: ubiquitin specific peptidase 40 | Alias Symbol: FLJ10785 | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 55230 | HGNC ID: HGNC:20069 | Ensembl Gene: ENSG00000085982 | OMIM ID: 610570 |
| Drug and gene relationship at DGIdb | |||
Expression of USP40:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USP40 | 55230 | 225085_at | -0.0682 | 0.8978 | |
| GSE26886 | USP40 | 55230 | 225085_at | 0.0606 | 0.7990 | |
| GSE45670 | USP40 | 55230 | 225085_at | 0.1603 | 0.4099 | |
| GSE53622 | USP40 | 55230 | 85471 | 0.2101 | 0.0149 | |
| GSE53624 | USP40 | 55230 | 85471 | 0.1935 | 0.0183 | |
| GSE63941 | USP40 | 55230 | 225085_at | 0.1435 | 0.8549 | |
| GSE77861 | USP40 | 55230 | 225085_at | 0.1586 | 0.3521 | |
| GSE97050 | USP40 | 55230 | A_23_P343594 | 0.0476 | 0.8221 | |
| SRP007169 | USP40 | 55230 | RNAseq | 0.7151 | 0.1081 | |
| SRP008496 | USP40 | 55230 | RNAseq | 0.9492 | 0.0007 | |
| SRP064894 | USP40 | 55230 | RNAseq | 0.0709 | 0.6143 | |
| SRP133303 | USP40 | 55230 | RNAseq | -0.0674 | 0.6450 | |
| SRP159526 | USP40 | 55230 | RNAseq | -0.1484 | 0.5966 | |
| SRP193095 | USP40 | 55230 | RNAseq | -0.0372 | 0.7283 | |
| SRP219564 | USP40 | 55230 | RNAseq | -0.2673 | 0.4451 | |
| TCGA | USP40 | 55230 | RNAseq | -0.1350 | 0.0111 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by USP40 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of USP40:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USP40 | 55230 | 1 | 11 | 18 | |
| GSE20123 | USP40 | 55230 | 1 | 11 | 18 | |
| GSE43470 | USP40 | 55230 | 1 | 9 | 33 | |
| GSE46452 | USP40 | 55230 | 0 | 5 | 54 | |
| GSE47630 | USP40 | 55230 | 4 | 5 | 31 | |
| GSE54993 | USP40 | 55230 | 3 | 2 | 65 | |
| GSE54994 | USP40 | 55230 | 6 | 10 | 37 | |
| GSE60625 | USP40 | 55230 | 0 | 3 | 8 | |
| GSE74703 | USP40 | 55230 | 1 | 7 | 28 | |
| GSE74704 | USP40 | 55230 | 1 | 5 | 14 | |
| TCGA | USP40 | 55230 | 12 | 28 | 56 |
Total number of gains: 30; Total number of losses: 96; Total Number of normals: 362.
Somatic mutations of USP40:
Generating mutation plots.
Highly correlated genes for USP40:
Showing top 20/128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USP40 | C6orf141 | 0.840041 | 3 | 0 | 3 |
| USP40 | TMCC3 | 0.80622 | 3 | 0 | 3 |
| USP40 | MYOF | 0.779802 | 3 | 0 | 3 |
| USP40 | INVS | 0.770759 | 3 | 0 | 3 |
| USP40 | FLNB | 0.770434 | 3 | 0 | 3 |
| USP40 | MCTP1 | 0.767051 | 3 | 0 | 3 |
| USP40 | MCC | 0.765303 | 3 | 0 | 3 |
| USP40 | USP32 | 0.764924 | 3 | 0 | 3 |
| USP40 | STK17A | 0.755169 | 3 | 0 | 3 |
| USP40 | PRSS36 | 0.754411 | 3 | 0 | 3 |
| USP40 | TRIP11 | 0.754374 | 3 | 0 | 3 |
| USP40 | MARK3 | 0.746851 | 3 | 0 | 3 |
| USP40 | NAPG | 0.74634 | 3 | 0 | 3 |
| USP40 | F2RL1 | 0.745729 | 3 | 0 | 3 |
| USP40 | PPP1R21 | 0.743275 | 3 | 0 | 3 |
| USP40 | SMURF1 | 0.739613 | 3 | 0 | 3 |
| USP40 | NAP1L4 | 0.736146 | 3 | 0 | 3 |
| USP40 | BCL7B | 0.73402 | 3 | 0 | 3 |
| USP40 | RAPGEF4 | 0.733904 | 3 | 0 | 3 |
| USP40 | CD109 | 0.733058 | 3 | 0 | 3 |
For details and further investigation, click here
