| Full name: UDP-N-acetylglucosamine pyrophosphorylase 1 | Alias Symbol: AGX1|AgX | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 6675 | HGNC ID: HGNC:12457 | Ensembl Gene: ENSG00000117143 | OMIM ID: 602862 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UAP1 | 6675 | 209340_at | -0.0509 | 0.9534 | |
| GSE20347 | UAP1 | 6675 | 209340_at | -0.2213 | 0.1941 | |
| GSE23400 | UAP1 | 6675 | 209340_at | -0.2095 | 0.0118 | |
| GSE26886 | UAP1 | 6675 | 209340_at | -0.0878 | 0.7912 | |
| GSE29001 | UAP1 | 6675 | 209340_at | -0.1215 | 0.8417 | |
| GSE38129 | UAP1 | 6675 | 209340_at | -0.2631 | 0.0814 | |
| GSE45670 | UAP1 | 6675 | 209340_at | -0.4529 | 0.0251 | |
| GSE53622 | UAP1 | 6675 | 41662 | -0.3095 | 0.0003 | |
| GSE53624 | UAP1 | 6675 | 41662 | -0.3882 | 0.0000 | |
| GSE63941 | UAP1 | 6675 | 209340_at | -1.1846 | 0.0560 | |
| GSE77861 | UAP1 | 6675 | 209340_at | -0.0792 | 0.8357 | |
| GSE97050 | UAP1 | 6675 | A_23_P160460 | -0.0572 | 0.8319 | |
| SRP007169 | UAP1 | 6675 | RNAseq | -0.5568 | 0.2146 | |
| SRP008496 | UAP1 | 6675 | RNAseq | 0.1627 | 0.6508 | |
| SRP064894 | UAP1 | 6675 | RNAseq | -0.7856 | 0.0023 | |
| SRP133303 | UAP1 | 6675 | RNAseq | -0.0552 | 0.8016 | |
| SRP159526 | UAP1 | 6675 | RNAseq | -0.3353 | 0.3241 | |
| SRP193095 | UAP1 | 6675 | RNAseq | -0.5216 | 0.0007 | |
| SRP219564 | UAP1 | 6675 | RNAseq | 0.0822 | 0.8032 | |
| TCGA | UAP1 | 6675 | RNAseq | -0.2834 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UAP1 | 6675 | 10 | 0 | 20 | |
| GSE20123 | UAP1 | 6675 | 10 | 0 | 20 | |
| GSE43470 | UAP1 | 6675 | 7 | 2 | 34 | |
| GSE46452 | UAP1 | 6675 | 2 | 1 | 56 | |
| GSE47630 | UAP1 | 6675 | 14 | 0 | 26 | |
| GSE54993 | UAP1 | 6675 | 0 | 5 | 65 | |
| GSE54994 | UAP1 | 6675 | 16 | 0 | 37 | |
| GSE60625 | UAP1 | 6675 | 0 | 0 | 11 | |
| GSE74703 | UAP1 | 6675 | 7 | 2 | 27 | |
| GSE74704 | UAP1 | 6675 | 4 | 0 | 16 | |
| TCGA | UAP1 | 6675 | 42 | 4 | 50 |
Total number of gains: 112; Total number of losses: 14; Total Number of normals: 362.
Somatic mutations of UAP1:
Generating mutation plots.
Highly correlated genes for UAP1:
Showing top 20/280 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UAP1 | CYP20A1 | 0.768762 | 3 | 0 | 3 |
| UAP1 | HIC1 | 0.750857 | 3 | 0 | 3 |
| UAP1 | BCAS2 | 0.746136 | 3 | 0 | 3 |
| UAP1 | ZBED6 | 0.741452 | 3 | 0 | 3 |
| UAP1 | CYTH3 | 0.741387 | 3 | 0 | 3 |
| UAP1 | HERC4 | 0.736047 | 3 | 0 | 3 |
| UAP1 | LYAR | 0.732609 | 3 | 0 | 3 |
| UAP1 | MOB4 | 0.723278 | 3 | 0 | 3 |
| UAP1 | ACTN1 | 0.723165 | 3 | 0 | 3 |
| UAP1 | TSNAX | 0.723074 | 3 | 0 | 3 |
| UAP1 | DNAJB14 | 0.712152 | 4 | 0 | 3 |
| UAP1 | CHIC1 | 0.705452 | 3 | 0 | 3 |
| UAP1 | KTN1 | 0.701495 | 3 | 0 | 3 |
| UAP1 | PNMA1 | 0.695456 | 3 | 0 | 3 |
| UAP1 | METTL14 | 0.688455 | 3 | 0 | 3 |
| UAP1 | NUDT9 | 0.682867 | 4 | 0 | 4 |
| UAP1 | ANAPC4 | 0.679711 | 4 | 0 | 3 |
| UAP1 | SENP6 | 0.675292 | 3 | 0 | 3 |
| UAP1 | BMPR2 | 0.673468 | 4 | 0 | 3 |
| UAP1 | PALLD | 0.672252 | 3 | 0 | 3 |
For details and further investigation, click here
