| Full name: HECT and RLD domain containing E3 ubiquitin protein ligase 4 | Alias Symbol: DKFZP564G092|KIAA1593 | ||
| Type: protein-coding gene | Cytoband: 10q21.3 | ||
| Entrez ID: 26091 | HGNC ID: HGNC:24521 | Ensembl Gene: ENSG00000148634 | OMIM ID: 609248 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of HERC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HERC4 | 26091 | 225988_at | 0.2693 | 0.6354 | |
| GSE20347 | HERC4 | 26091 | 208055_s_at | -0.0887 | 0.3620 | |
| GSE23400 | HERC4 | 26091 | 208055_s_at | -0.0079 | 0.8034 | |
| GSE26886 | HERC4 | 26091 | 225988_at | -0.0454 | 0.8891 | |
| GSE29001 | HERC4 | 26091 | 208054_at | 0.1683 | 0.5040 | |
| GSE38129 | HERC4 | 26091 | 208055_s_at | 0.0586 | 0.6416 | |
| GSE45670 | HERC4 | 26091 | 225988_at | 0.0575 | 0.7857 | |
| GSE53622 | HERC4 | 26091 | 146317 | -0.1029 | 0.2896 | |
| GSE53624 | HERC4 | 26091 | 146317 | -0.0626 | 0.4294 | |
| GSE63941 | HERC4 | 26091 | 225988_at | -1.2527 | 0.0414 | |
| GSE77861 | HERC4 | 26091 | 225988_at | -0.3106 | 0.1524 | |
| GSE97050 | HERC4 | 26091 | A_23_P202408 | -0.0792 | 0.8565 | |
| SRP007169 | HERC4 | 26091 | RNAseq | -1.1971 | 0.0007 | |
| SRP008496 | HERC4 | 26091 | RNAseq | -0.9007 | 0.0000 | |
| SRP064894 | HERC4 | 26091 | RNAseq | -0.2396 | 0.1822 | |
| SRP133303 | HERC4 | 26091 | RNAseq | 0.1018 | 0.4167 | |
| SRP159526 | HERC4 | 26091 | RNAseq | -0.5736 | 0.0562 | |
| SRP193095 | HERC4 | 26091 | RNAseq | -0.2691 | 0.0017 | |
| SRP219564 | HERC4 | 26091 | RNAseq | -0.2195 | 0.4096 | |
| TCGA | HERC4 | 26091 | RNAseq | 0.0352 | 0.4901 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HERC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HERC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HERC4 | 26091 | 2 | 5 | 23 | |
| GSE20123 | HERC4 | 26091 | 2 | 4 | 24 | |
| GSE43470 | HERC4 | 26091 | 1 | 8 | 34 | |
| GSE46452 | HERC4 | 26091 | 0 | 11 | 48 | |
| GSE47630 | HERC4 | 26091 | 2 | 14 | 24 | |
| GSE54993 | HERC4 | 26091 | 8 | 0 | 62 | |
| GSE54994 | HERC4 | 26091 | 2 | 12 | 39 | |
| GSE60625 | HERC4 | 26091 | 0 | 0 | 11 | |
| GSE74703 | HERC4 | 26091 | 1 | 5 | 30 | |
| GSE74704 | HERC4 | 26091 | 1 | 3 | 16 | |
| TCGA | HERC4 | 26091 | 10 | 22 | 64 |
Total number of gains: 29; Total number of losses: 84; Total Number of normals: 375.
Somatic mutations of HERC4:
Generating mutation plots.
Highly correlated genes for HERC4:
Showing top 20/315 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HERC4 | ALG14 | 0.788108 | 3 | 0 | 3 |
| HERC4 | PPP2R5E | 0.763787 | 3 | 0 | 3 |
| HERC4 | USP4 | 0.750569 | 3 | 0 | 3 |
| HERC4 | PTTG1IP | 0.746553 | 3 | 0 | 3 |
| HERC4 | C2orf76 | 0.744563 | 4 | 0 | 4 |
| HERC4 | UAP1 | 0.736047 | 3 | 0 | 3 |
| HERC4 | MYH3 | 0.731902 | 3 | 0 | 3 |
| HERC4 | BTBD7 | 0.727675 | 3 | 0 | 3 |
| HERC4 | CMC1 | 0.727292 | 3 | 0 | 3 |
| HERC4 | GOLGA3 | 0.727208 | 3 | 0 | 3 |
| HERC4 | MDM2 | 0.726423 | 3 | 0 | 3 |
| HERC4 | STX6 | 0.723332 | 4 | 0 | 3 |
| HERC4 | PUM1 | 0.71797 | 3 | 0 | 3 |
| HERC4 | EBPL | 0.717625 | 3 | 0 | 3 |
| HERC4 | MED4 | 0.71714 | 4 | 0 | 4 |
| HERC4 | ATL1 | 0.708846 | 3 | 0 | 3 |
| HERC4 | SUSD1 | 0.705609 | 3 | 0 | 3 |
| HERC4 | SGSH | 0.704143 | 3 | 0 | 3 |
| HERC4 | UBE2B | 0.699507 | 3 | 0 | 3 |
| HERC4 | GDAP2 | 0.69932 | 3 | 0 | 3 |
For details and further investigation, click here
