| Full name: ubiquitin protein ligase E3 component n-recognin 3 | Alias Symbol: KIAA2024|DKFZp434P117|FLJ37422 | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 130507 | HGNC ID: HGNC:30467 | Ensembl Gene: ENSG00000144357 | OMIM ID: 613831 |
| Drug and gene relationship at DGIdb | |||
Expression of UBR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UBR3 | 130507 | 230029_x_at | -0.1315 | 0.7383 | |
| GSE26886 | UBR3 | 130507 | 230029_x_at | 0.0363 | 0.9142 | |
| GSE45670 | UBR3 | 130507 | 230029_x_at | -0.3102 | 0.0070 | |
| GSE53622 | UBR3 | 130507 | 34328 | -0.3165 | 0.0000 | |
| GSE53624 | UBR3 | 130507 | 34328 | -0.3246 | 0.0002 | |
| GSE63941 | UBR3 | 130507 | 230029_x_at | -1.2354 | 0.0059 | |
| GSE77861 | UBR3 | 130507 | 230029_x_at | -0.1426 | 0.5063 | |
| GSE97050 | UBR3 | 130507 | A_24_P285501 | -0.1565 | 0.5212 | |
| SRP007169 | UBR3 | 130507 | RNAseq | 0.1398 | 0.7281 | |
| SRP008496 | UBR3 | 130507 | RNAseq | 0.3687 | 0.0662 | |
| SRP064894 | UBR3 | 130507 | RNAseq | -0.3973 | 0.1300 | |
| SRP133303 | UBR3 | 130507 | RNAseq | -0.0035 | 0.9652 | |
| SRP159526 | UBR3 | 130507 | RNAseq | -0.1698 | 0.5048 | |
| SRP193095 | UBR3 | 130507 | RNAseq | -0.1005 | 0.2444 | |
| SRP219564 | UBR3 | 130507 | RNAseq | -0.1414 | 0.6032 | |
| TCGA | UBR3 | 130507 | RNAseq | -0.0893 | 0.0542 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by UBR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UBR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UBR3 | 130507 | 8 | 0 | 22 | |
| GSE20123 | UBR3 | 130507 | 8 | 0 | 22 | |
| GSE43470 | UBR3 | 130507 | 5 | 1 | 37 | |
| GSE46452 | UBR3 | 130507 | 1 | 4 | 54 | |
| GSE47630 | UBR3 | 130507 | 5 | 3 | 32 | |
| GSE54993 | UBR3 | 130507 | 0 | 5 | 65 | |
| GSE54994 | UBR3 | 130507 | 11 | 3 | 39 | |
| GSE60625 | UBR3 | 130507 | 0 | 3 | 8 | |
| GSE74703 | UBR3 | 130507 | 4 | 1 | 31 | |
| GSE74704 | UBR3 | 130507 | 5 | 0 | 15 | |
| TCGA | UBR3 | 130507 | 24 | 10 | 62 |
Total number of gains: 71; Total number of losses: 30; Total Number of normals: 387.
Somatic mutations of UBR3:
Generating mutation plots.
Highly correlated genes for UBR3:
Showing top 20/525 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UBR3 | ZDHHC17 | 0.852785 | 3 | 0 | 3 |
| UBR3 | VTI1B | 0.820026 | 3 | 0 | 3 |
| UBR3 | DECR1 | 0.799281 | 3 | 0 | 3 |
| UBR3 | WDR36 | 0.78828 | 3 | 0 | 3 |
| UBR3 | PCSK5 | 0.762852 | 3 | 0 | 3 |
| UBR3 | PCMTD2 | 0.754607 | 3 | 0 | 3 |
| UBR3 | POLR3GL | 0.752755 | 3 | 0 | 3 |
| UBR3 | SEC22C | 0.751207 | 3 | 0 | 3 |
| UBR3 | THAP5 | 0.747915 | 3 | 0 | 3 |
| UBR3 | UBE4A | 0.741521 | 3 | 0 | 3 |
| UBR3 | RSL24D1 | 0.74052 | 3 | 0 | 3 |
| UBR3 | DPY19L3 | 0.740475 | 3 | 0 | 3 |
| UBR3 | BCLAF1 | 0.740284 | 4 | 0 | 4 |
| UBR3 | KBTBD6 | 0.739388 | 3 | 0 | 3 |
| UBR3 | BTBD1 | 0.737559 | 3 | 0 | 3 |
| UBR3 | SLC30A5 | 0.734978 | 4 | 0 | 4 |
| UBR3 | MRFAP1L1 | 0.734488 | 3 | 0 | 3 |
| UBR3 | CCDC93 | 0.732742 | 3 | 0 | 3 |
| UBR3 | ARL5A | 0.732662 | 3 | 0 | 3 |
| UBR3 | SUN1 | 0.729808 | 3 | 0 | 3 |
For details and further investigation, click here
