| Full name: proprotein convertase subtilisin/kexin type 5 | Alias Symbol: PC5|PC6|SPC6 | ||
| Type: protein-coding gene | Cytoband: 9q21.13 | ||
| Entrez ID: 5125 | HGNC ID: HGNC:8747 | Ensembl Gene: ENSG00000099139 | OMIM ID: 600488 |
| Drug and gene relationship at DGIdb | |||
Expression of PCSK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCSK5 | 5125 | 205559_s_at | -1.1442 | 0.2315 | |
| GSE20347 | PCSK5 | 5125 | 205559_s_at | -1.0494 | 0.0130 | |
| GSE23400 | PCSK5 | 5125 | 205559_s_at | -0.5816 | 0.0008 | |
| GSE26886 | PCSK5 | 5125 | 205559_s_at | -1.9393 | 0.0032 | |
| GSE29001 | PCSK5 | 5125 | 205559_s_at | -1.0375 | 0.1157 | |
| GSE38129 | PCSK5 | 5125 | 205559_s_at | -0.9302 | 0.0083 | |
| GSE45670 | PCSK5 | 5125 | 205559_s_at | -0.8814 | 0.0995 | |
| GSE53622 | PCSK5 | 5125 | 21688 | -0.8104 | 0.0000 | |
| GSE53624 | PCSK5 | 5125 | 21688 | -0.8357 | 0.0000 | |
| GSE63941 | PCSK5 | 5125 | 205559_s_at | -4.3030 | 0.0002 | |
| GSE77861 | PCSK5 | 5125 | 205559_s_at | -0.5692 | 0.4493 | |
| GSE97050 | PCSK5 | 5125 | A_23_P257003 | -0.4987 | 0.2110 | |
| SRP007169 | PCSK5 | 5125 | RNAseq | -1.2394 | 0.0697 | |
| SRP008496 | PCSK5 | 5125 | RNAseq | -1.3692 | 0.0407 | |
| SRP064894 | PCSK5 | 5125 | RNAseq | -1.1788 | 0.0003 | |
| SRP133303 | PCSK5 | 5125 | RNAseq | -1.0967 | 0.0006 | |
| SRP159526 | PCSK5 | 5125 | RNAseq | -0.7954 | 0.0456 | |
| SRP193095 | PCSK5 | 5125 | RNAseq | -1.0730 | 0.0000 | |
| SRP219564 | PCSK5 | 5125 | RNAseq | -1.0791 | 0.0618 | |
| TCGA | PCSK5 | 5125 | RNAseq | -0.0667 | 0.7368 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PCSK5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCSK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCSK5 | 5125 | 6 | 10 | 14 | |
| GSE20123 | PCSK5 | 5125 | 6 | 10 | 14 | |
| GSE43470 | PCSK5 | 5125 | 6 | 5 | 32 | |
| GSE46452 | PCSK5 | 5125 | 6 | 14 | 39 | |
| GSE47630 | PCSK5 | 5125 | 1 | 18 | 21 | |
| GSE54993 | PCSK5 | 5125 | 4 | 2 | 64 | |
| GSE54994 | PCSK5 | 5125 | 4 | 13 | 36 | |
| GSE60625 | PCSK5 | 5125 | 0 | 0 | 11 | |
| GSE74703 | PCSK5 | 5125 | 5 | 4 | 27 | |
| GSE74704 | PCSK5 | 5125 | 3 | 7 | 10 | |
| TCGA | PCSK5 | 5125 | 18 | 30 | 48 |
Total number of gains: 59; Total number of losses: 113; Total Number of normals: 316.
Somatic mutations of PCSK5:
Generating mutation plots.
Highly correlated genes for PCSK5:
Showing top 20/568 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCSK5 | UBR3 | 0.762852 | 3 | 0 | 3 |
| PCSK5 | FNIP1 | 0.762673 | 3 | 0 | 3 |
| PCSK5 | SCOC | 0.754424 | 3 | 0 | 3 |
| PCSK5 | RBKS | 0.74044 | 3 | 0 | 3 |
| PCSK5 | PPP2R5C | 0.738963 | 3 | 0 | 3 |
| PCSK5 | EDNRB | 0.728242 | 3 | 0 | 3 |
| PCSK5 | CD109 | 0.727791 | 3 | 0 | 3 |
| PCSK5 | COL15A1 | 0.724887 | 3 | 0 | 3 |
| PCSK5 | ANKRD9 | 0.724878 | 3 | 0 | 3 |
| PCSK5 | WDR36 | 0.721747 | 3 | 0 | 3 |
| PCSK5 | RNF111 | 0.709913 | 3 | 0 | 3 |
| PCSK5 | ACER3 | 0.709766 | 4 | 0 | 4 |
| PCSK5 | TK2 | 0.708625 | 4 | 0 | 4 |
| PCSK5 | YIPF4 | 0.70607 | 3 | 0 | 3 |
| PCSK5 | RRAGB | 0.703031 | 3 | 0 | 3 |
| PCSK5 | CEPT1 | 0.698713 | 3 | 0 | 3 |
| PCSK5 | WDR61 | 0.696673 | 3 | 0 | 3 |
| PCSK5 | EIF2B4 | 0.691114 | 5 | 0 | 4 |
| PCSK5 | FOXN3 | 0.690794 | 4 | 0 | 4 |
| PCSK5 | HIF1A | 0.689592 | 3 | 0 | 3 |
For details and further investigation, click here
