| Full name: pyroglutamyl-peptidase I | Alias Symbol: PGP-I|Pcp|PGP|PGPI | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 54858 | HGNC ID: HGNC:13568 | Ensembl Gene: ENSG00000130517 | OMIM ID: 610694 |
| Drug and gene relationship at DGIdb | |||
Expression of PGPEP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGPEP1 | 54858 | 237202_at | -0.1741 | 0.3133 | |
| GSE20347 | PGPEP1 | 54858 | 219891_at | 0.1232 | 0.1537 | |
| GSE23400 | PGPEP1 | 54858 | 219891_at | -0.1893 | 0.0000 | |
| GSE26886 | PGPEP1 | 54858 | 237202_at | 0.1850 | 0.0952 | |
| GSE29001 | PGPEP1 | 54858 | 219891_at | -0.0210 | 0.9280 | |
| GSE38129 | PGPEP1 | 54858 | 219891_at | -0.0688 | 0.5053 | |
| GSE45670 | PGPEP1 | 54858 | 219891_at | -0.1037 | 0.4506 | |
| GSE53622 | PGPEP1 | 54858 | 51001 | -0.6756 | 0.0000 | |
| GSE53624 | PGPEP1 | 54858 | 76478 | -0.3730 | 0.0000 | |
| GSE63941 | PGPEP1 | 54858 | 237202_at | -0.1292 | 0.5946 | |
| GSE77861 | PGPEP1 | 54858 | 237202_at | 0.0664 | 0.6161 | |
| GSE97050 | PGPEP1 | 54858 | A_23_P327370 | -0.2181 | 0.4020 | |
| SRP007169 | PGPEP1 | 54858 | RNAseq | 0.6464 | 0.1736 | |
| SRP008496 | PGPEP1 | 54858 | RNAseq | 0.5492 | 0.1174 | |
| SRP064894 | PGPEP1 | 54858 | RNAseq | -0.4335 | 0.1096 | |
| SRP133303 | PGPEP1 | 54858 | RNAseq | -0.4050 | 0.0219 | |
| SRP159526 | PGPEP1 | 54858 | RNAseq | 0.1186 | 0.7145 | |
| SRP193095 | PGPEP1 | 54858 | RNAseq | -0.0057 | 0.9848 | |
| SRP219564 | PGPEP1 | 54858 | RNAseq | -0.1804 | 0.7153 | |
| TCGA | PGPEP1 | 54858 | RNAseq | -0.7083 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PGPEP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PGPEP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGPEP1 | 54858 | 4 | 4 | 22 | |
| GSE20123 | PGPEP1 | 54858 | 3 | 2 | 25 | |
| GSE43470 | PGPEP1 | 54858 | 2 | 5 | 36 | |
| GSE46452 | PGPEP1 | 54858 | 47 | 1 | 11 | |
| GSE47630 | PGPEP1 | 54858 | 4 | 8 | 28 | |
| GSE54993 | PGPEP1 | 54858 | 15 | 4 | 51 | |
| GSE54994 | PGPEP1 | 54858 | 6 | 13 | 34 | |
| GSE60625 | PGPEP1 | 54858 | 9 | 0 | 2 | |
| GSE74703 | PGPEP1 | 54858 | 2 | 3 | 31 | |
| GSE74704 | PGPEP1 | 54858 | 0 | 2 | 18 | |
| TCGA | PGPEP1 | 54858 | 16 | 10 | 70 |
Total number of gains: 108; Total number of losses: 52; Total Number of normals: 328.
Somatic mutations of PGPEP1:
Generating mutation plots.
Highly correlated genes for PGPEP1:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGPEP1 | HRCT1 | 0.768268 | 3 | 0 | 3 |
| PGPEP1 | SYPL2 | 0.76075 | 3 | 0 | 3 |
| PGPEP1 | C22orf39 | 0.758514 | 3 | 0 | 3 |
| PGPEP1 | ARMC7 | 0.740883 | 3 | 0 | 3 |
| PGPEP1 | DOK7 | 0.737852 | 4 | 0 | 3 |
| PGPEP1 | MPP3 | 0.716208 | 3 | 0 | 3 |
| PGPEP1 | PGAM2 | 0.714344 | 3 | 0 | 3 |
| PGPEP1 | TEF | 0.712878 | 3 | 0 | 3 |
| PGPEP1 | FAM228B | 0.709466 | 3 | 0 | 3 |
| PGPEP1 | HMGCLL1 | 0.706885 | 4 | 0 | 3 |
| PGPEP1 | ADAMTSL1 | 0.703583 | 3 | 0 | 3 |
| PGPEP1 | MIR100HG | 0.703393 | 3 | 0 | 3 |
| PGPEP1 | CELF4 | 0.689499 | 3 | 0 | 3 |
| PGPEP1 | ADCY5 | 0.689309 | 3 | 0 | 3 |
| PGPEP1 | ZNF692 | 0.688063 | 3 | 0 | 3 |
| PGPEP1 | PPP1R12C | 0.685187 | 5 | 0 | 5 |
| PGPEP1 | ADAP1 | 0.684498 | 4 | 0 | 4 |
| PGPEP1 | UCK1 | 0.679635 | 3 | 0 | 3 |
| PGPEP1 | SP7 | 0.6741 | 3 | 0 | 3 |
| PGPEP1 | NEGR1 | 0.672997 | 3 | 0 | 3 |
For details and further investigation, click here
