| Full name: protein phosphatase, Mg2+/Mn2+ dependent 1F | Alias Symbol: FEM-2|KIAA0015|POPX2|CaMKPase|CAMKP | ||
| Type: protein-coding gene | Cytoband: 22q11.22 | ||
| Entrez ID: 9647 | HGNC ID: HGNC:19388 | Ensembl Gene: ENSG00000100034 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PPM1F:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPM1F | 9647 | 203063_at | 0.1632 | 0.6433 | |
| GSE20347 | PPM1F | 9647 | 37384_at | -0.2007 | 0.0534 | |
| GSE23400 | PPM1F | 9647 | 37384_at | -0.1540 | 0.0001 | |
| GSE26886 | PPM1F | 9647 | 203063_at | -0.6958 | 0.0000 | |
| GSE29001 | PPM1F | 9647 | 37384_at | -0.0335 | 0.8788 | |
| GSE38129 | PPM1F | 9647 | 37384_at | -0.2496 | 0.0839 | |
| GSE45670 | PPM1F | 9647 | 37384_at | -0.1846 | 0.1467 | |
| GSE53622 | PPM1F | 9647 | 32762 | -0.3860 | 0.0000 | |
| GSE53624 | PPM1F | 9647 | 32762 | -0.0236 | 0.7734 | |
| GSE63941 | PPM1F | 9647 | 37384_at | -0.7920 | 0.0425 | |
| GSE77861 | PPM1F | 9647 | 37384_at | -0.0393 | 0.8403 | |
| GSE97050 | PPM1F | 9647 | A_23_P57413 | -0.1428 | 0.5924 | |
| SRP007169 | PPM1F | 9647 | RNAseq | -0.4030 | 0.3408 | |
| SRP008496 | PPM1F | 9647 | RNAseq | -0.3110 | 0.2870 | |
| SRP064894 | PPM1F | 9647 | RNAseq | 0.3605 | 0.0791 | |
| SRP133303 | PPM1F | 9647 | RNAseq | -0.6487 | 0.0001 | |
| SRP159526 | PPM1F | 9647 | RNAseq | -0.1860 | 0.4661 | |
| SRP193095 | PPM1F | 9647 | RNAseq | 0.2469 | 0.1155 | |
| SRP219564 | PPM1F | 9647 | RNAseq | -0.0896 | 0.7174 | |
| TCGA | PPM1F | 9647 | RNAseq | -0.0379 | 0.4798 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPM1F expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPM1F:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPM1F | 9647 | 5 | 7 | 18 | |
| GSE20123 | PPM1F | 9647 | 5 | 7 | 18 | |
| GSE43470 | PPM1F | 9647 | 3 | 7 | 33 | |
| GSE46452 | PPM1F | 9647 | 33 | 1 | 25 | |
| GSE47630 | PPM1F | 9647 | 8 | 5 | 27 | |
| GSE54993 | PPM1F | 9647 | 3 | 6 | 61 | |
| GSE54994 | PPM1F | 9647 | 11 | 7 | 35 | |
| GSE60625 | PPM1F | 9647 | 5 | 0 | 6 | |
| GSE74703 | PPM1F | 9647 | 3 | 5 | 28 | |
| GSE74704 | PPM1F | 9647 | 2 | 4 | 14 | |
| TCGA | PPM1F | 9647 | 27 | 16 | 53 |
Total number of gains: 105; Total number of losses: 65; Total Number of normals: 318.
Somatic mutations of PPM1F:
Generating mutation plots.
Highly correlated genes for PPM1F:
Showing top 20/50 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPM1F | TMEM217 | 0.758049 | 3 | 0 | 3 |
| PPM1F | ZNF678 | 0.754933 | 3 | 0 | 3 |
| PPM1F | CYP2E1 | 0.707582 | 3 | 0 | 3 |
| PPM1F | ZNF230 | 0.697205 | 3 | 0 | 3 |
| PPM1F | MFSD11 | 0.689789 | 3 | 0 | 3 |
| PPM1F | UCK1 | 0.67217 | 3 | 0 | 3 |
| PPM1F | DNAL4 | 0.669339 | 3 | 0 | 3 |
| PPM1F | P2RX5 | 0.669157 | 3 | 0 | 3 |
| PPM1F | LAT | 0.659454 | 4 | 0 | 3 |
| PPM1F | GRIPAP1 | 0.659453 | 4 | 0 | 3 |
| PPM1F | SEMA5A | 0.652585 | 5 | 0 | 4 |
| PPM1F | SPINT3 | 0.650826 | 3 | 0 | 3 |
| PPM1F | SLC35B4 | 0.650817 | 5 | 0 | 4 |
| PPM1F | RUSC1 | 0.646689 | 4 | 0 | 3 |
| PPM1F | CARD8 | 0.643037 | 5 | 0 | 3 |
| PPM1F | PDZRN3 | 0.639157 | 5 | 0 | 3 |
| PPM1F | MAST3 | 0.625239 | 5 | 0 | 4 |
| PPM1F | FASTK | 0.623628 | 5 | 0 | 3 |
| PPM1F | ICAM3 | 0.623258 | 5 | 0 | 4 |
| PPM1F | AGPAT1 | 0.613877 | 6 | 0 | 3 |
For details and further investigation, click here
