| Full name: UDP-glucose ceramide glucosyltransferase | Alias Symbol: GCS | ||
| Type: protein-coding gene | Cytoband: 9q31.3 | ||
| Entrez ID: 7357 | HGNC ID: HGNC:12524 | Ensembl Gene: ENSG00000148154 | OMIM ID: 602874 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UGCG:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UGCG | 7357 | 224967_at | -0.3267 | 0.6615 | |
| GSE20347 | UGCG | 7357 | 204881_s_at | -0.7548 | 0.0009 | |
| GSE23400 | UGCG | 7357 | 204881_s_at | -0.8879 | 0.0000 | |
| GSE26886 | UGCG | 7357 | 224967_at | -0.7185 | 0.0135 | |
| GSE29001 | UGCG | 7357 | 204881_s_at | -1.0954 | 0.0160 | |
| GSE38129 | UGCG | 7357 | 204881_s_at | -0.5585 | 0.2614 | |
| GSE45670 | UGCG | 7357 | 224967_at | -0.0164 | 0.9583 | |
| GSE53622 | UGCG | 7357 | 53096 | -0.7464 | 0.0000 | |
| GSE53624 | UGCG | 7357 | 53096 | -0.8577 | 0.0000 | |
| GSE63941 | UGCG | 7357 | 204881_s_at | 1.5202 | 0.0429 | |
| GSE77861 | UGCG | 7357 | 224967_at | -0.5110 | 0.1401 | |
| GSE97050 | UGCG | 7357 | A_23_P313389 | 0.0443 | 0.9414 | |
| SRP007169 | UGCG | 7357 | RNAseq | -1.8432 | 0.0000 | |
| SRP008496 | UGCG | 7357 | RNAseq | -1.6323 | 0.0000 | |
| SRP064894 | UGCG | 7357 | RNAseq | -0.9237 | 0.0000 | |
| SRP133303 | UGCG | 7357 | RNAseq | -0.3990 | 0.0463 | |
| SRP159526 | UGCG | 7357 | RNAseq | -1.0897 | 0.0014 | |
| SRP193095 | UGCG | 7357 | RNAseq | -0.8431 | 0.0000 | |
| SRP219564 | UGCG | 7357 | RNAseq | -0.7752 | 0.0787 | |
| TCGA | UGCG | 7357 | RNAseq | -0.2892 | 0.0009 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by UGCG expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UGCG:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UGCG | 7357 | 5 | 9 | 16 | |
| GSE20123 | UGCG | 7357 | 5 | 9 | 16 | |
| GSE43470 | UGCG | 7357 | 4 | 3 | 36 | |
| GSE46452 | UGCG | 7357 | 6 | 13 | 40 | |
| GSE47630 | UGCG | 7357 | 3 | 16 | 21 | |
| GSE54993 | UGCG | 7357 | 3 | 3 | 64 | |
| GSE54994 | UGCG | 7357 | 9 | 10 | 34 | |
| GSE60625 | UGCG | 7357 | 0 | 0 | 11 | |
| GSE74703 | UGCG | 7357 | 4 | 3 | 29 | |
| GSE74704 | UGCG | 7357 | 2 | 7 | 11 | |
| TCGA | UGCG | 7357 | 26 | 21 | 49 |
Total number of gains: 67; Total number of losses: 94; Total Number of normals: 327.
Somatic mutations of UGCG:
Generating mutation plots.
Highly correlated genes for UGCG:
Showing top 20/933 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UGCG | ESR2 | 0.764482 | 3 | 0 | 3 |
| UGCG | ZNF597 | 0.733893 | 3 | 0 | 3 |
| UGCG | OGFOD1 | 0.723588 | 3 | 0 | 3 |
| UGCG | SEC22B | 0.719752 | 3 | 0 | 3 |
| UGCG | PPP3CC | 0.696104 | 3 | 0 | 3 |
| UGCG | CHM | 0.691486 | 3 | 0 | 3 |
| UGCG | TOM1L1 | 0.683243 | 4 | 0 | 3 |
| UGCG | UNC5B | 0.679939 | 3 | 0 | 3 |
| UGCG | GNL3 | 0.678752 | 3 | 0 | 3 |
| UGCG | ZNF460 | 0.677802 | 4 | 0 | 4 |
| UGCG | ZSWIM8 | 0.669913 | 3 | 0 | 3 |
| UGCG | NAPG | 0.666698 | 3 | 0 | 3 |
| UGCG | THUMPD3 | 0.662875 | 3 | 0 | 3 |
| UGCG | FOPNL | 0.662727 | 3 | 0 | 3 |
| UGCG | FASTKD1 | 0.661118 | 3 | 0 | 3 |
| UGCG | CA13 | 0.660075 | 3 | 0 | 3 |
| UGCG | PLD1 | 0.659401 | 10 | 0 | 10 |
| UGCG | FRMD4B | 0.656312 | 10 | 0 | 10 |
| UGCG | ARL4A | 0.653474 | 4 | 0 | 3 |
| UGCG | PRDM1 | 0.651356 | 10 | 0 | 9 |
For details and further investigation, click here
