| Full name: estrogen receptor 2 | Alias Symbol: NR3A2|Erb|ER-beta | ||
| Type: protein-coding gene | Cytoband: 14q23.2-q23.3 | ||
| Entrez ID: 2100 | HGNC ID: HGNC:3468 | Ensembl Gene: ENSG00000140009 | OMIM ID: 601663 |
| Drug and gene relationship at DGIdb | |||
ESR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04915 | Estrogen signaling pathway | |
| hsa04917 | Prolactin signaling pathway |
Expression of ESR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ESR2 | 2100 | 210780_at | 0.0185 | 0.9556 | |
| GSE20347 | ESR2 | 2100 | 210780_at | 0.0023 | 0.9861 | |
| GSE23400 | ESR2 | 2100 | 210780_at | -0.0619 | 0.0586 | |
| GSE26886 | ESR2 | 2100 | 210780_at | -0.2068 | 0.0638 | |
| GSE29001 | ESR2 | 2100 | 210780_at | -0.0494 | 0.7976 | |
| GSE38129 | ESR2 | 2100 | 210780_at | -0.0547 | 0.6181 | |
| GSE45670 | ESR2 | 2100 | 210780_at | 0.0568 | 0.5697 | |
| GSE53622 | ESR2 | 2100 | 97568 | 0.1236 | 0.2183 | |
| GSE53624 | ESR2 | 2100 | 97568 | -0.0978 | 0.3320 | |
| GSE63941 | ESR2 | 2100 | 210780_at | -0.1121 | 0.3991 | |
| GSE77861 | ESR2 | 2100 | 210780_at | -0.0542 | 0.6783 | |
| GSE97050 | ESR2 | 2100 | A_23_P54100 | -0.0807 | 0.7252 | |
| SRP064894 | ESR2 | 2100 | RNAseq | 0.5619 | 0.0757 | |
| SRP133303 | ESR2 | 2100 | RNAseq | -0.5730 | 0.0113 | |
| SRP159526 | ESR2 | 2100 | RNAseq | 0.7390 | 0.1671 | |
| SRP193095 | ESR2 | 2100 | RNAseq | 0.1795 | 0.4072 | |
| SRP219564 | ESR2 | 2100 | RNAseq | -0.5607 | 0.3733 | |
| TCGA | ESR2 | 2100 | RNAseq | 0.3828 | 0.0725 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ESR2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ESR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ESR2 | 2100 | 7 | 3 | 20 | |
| GSE20123 | ESR2 | 2100 | 7 | 3 | 20 | |
| GSE43470 | ESR2 | 2100 | 8 | 2 | 33 | |
| GSE46452 | ESR2 | 2100 | 16 | 3 | 40 | |
| GSE47630 | ESR2 | 2100 | 11 | 9 | 20 | |
| GSE54993 | ESR2 | 2100 | 3 | 9 | 58 | |
| GSE54994 | ESR2 | 2100 | 18 | 5 | 30 | |
| GSE60625 | ESR2 | 2100 | 0 | 2 | 9 | |
| GSE74703 | ESR2 | 2100 | 7 | 2 | 27 | |
| GSE74704 | ESR2 | 2100 | 3 | 2 | 15 | |
| TCGA | ESR2 | 2100 | 32 | 14 | 50 |
Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.
Somatic mutations of ESR2:
Generating mutation plots.
Highly correlated genes for ESR2:
Showing top 20/553 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ESR2 | LIPF | 0.799694 | 3 | 0 | 3 |
| ESR2 | UGCG | 0.764482 | 3 | 0 | 3 |
| ESR2 | CBLC | 0.737233 | 3 | 0 | 3 |
| ESR2 | REPS1 | 0.736169 | 3 | 0 | 3 |
| ESR2 | ARPC5L | 0.732544 | 3 | 0 | 3 |
| ESR2 | NOXO1 | 0.72892 | 3 | 0 | 3 |
| ESR2 | TSSK6 | 0.727554 | 3 | 0 | 3 |
| ESR2 | AGFG1 | 0.723623 | 3 | 0 | 3 |
| ESR2 | ANO8 | 0.723315 | 3 | 0 | 3 |
| ESR2 | CDC42EP1 | 0.718481 | 3 | 0 | 3 |
| ESR2 | HUNK | 0.718204 | 3 | 0 | 3 |
| ESR2 | SERPINB9 | 0.715972 | 3 | 0 | 3 |
| ESR2 | XPNPEP2 | 0.715622 | 4 | 0 | 3 |
| ESR2 | ADAM15 | 0.71281 | 3 | 0 | 3 |
| ESR2 | GAS2L1 | 0.711477 | 3 | 0 | 3 |
| ESR2 | GABRR2 | 0.707244 | 5 | 0 | 5 |
| ESR2 | LRBA | 0.704698 | 3 | 0 | 3 |
| ESR2 | TNPO1 | 0.704238 | 3 | 0 | 3 |
| ESR2 | KCMF1 | 0.703341 | 4 | 0 | 3 |
| ESR2 | KCNK6 | 0.701795 | 3 | 0 | 3 |
For details and further investigation, click here
