| Full name: PR/SET domain 1 | Alias Symbol: PRDI-BF1 | ||
| Type: protein-coding gene | Cytoband: 6q21 | ||
| Entrez ID: 639 | HGNC ID: HGNC:9346 | Ensembl Gene: ENSG00000057657 | OMIM ID: 603423 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PRDM1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRDM1 | 639 | 228964_at | -1.2677 | 0.4477 | |
| GSE20347 | PRDM1 | 639 | 217192_s_at | -0.7207 | 0.0000 | |
| GSE23400 | PRDM1 | 639 | 217192_s_at | -0.8775 | 0.0000 | |
| GSE26886 | PRDM1 | 639 | 228964_at | -3.1822 | 0.0000 | |
| GSE29001 | PRDM1 | 639 | 217192_s_at | -0.9646 | 0.0005 | |
| GSE38129 | PRDM1 | 639 | 217192_s_at | -0.5594 | 0.0011 | |
| GSE45670 | PRDM1 | 639 | 228964_at | -0.6306 | 0.0349 | |
| GSE53622 | PRDM1 | 639 | 98086 | -0.9250 | 0.0000 | |
| GSE53624 | PRDM1 | 639 | 123243 | -2.0817 | 0.0000 | |
| GSE63941 | PRDM1 | 639 | 228964_at | 0.0892 | 0.9575 | |
| GSE77861 | PRDM1 | 639 | 228964_at | -1.3873 | 0.0064 | |
| GSE97050 | PRDM1 | 639 | A_23_P350451 | 0.7554 | 0.4399 | |
| SRP007169 | PRDM1 | 639 | RNAseq | -2.8104 | 0.0000 | |
| SRP008496 | PRDM1 | 639 | RNAseq | -2.5794 | 0.0000 | |
| SRP064894 | PRDM1 | 639 | RNAseq | -1.9280 | 0.0000 | |
| SRP133303 | PRDM1 | 639 | RNAseq | -0.8748 | 0.0087 | |
| SRP159526 | PRDM1 | 639 | RNAseq | -1.8832 | 0.0003 | |
| SRP193095 | PRDM1 | 639 | RNAseq | -1.1519 | 0.0000 | |
| SRP219564 | PRDM1 | 639 | RNAseq | -2.3122 | 0.0080 | |
| TCGA | PRDM1 | 639 | RNAseq | 0.2583 | 0.0141 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by PRDM1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRDM1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRDM1 | 639 | 3 | 3 | 24 | |
| GSE20123 | PRDM1 | 639 | 3 | 2 | 25 | |
| GSE43470 | PRDM1 | 639 | 3 | 1 | 39 | |
| GSE46452 | PRDM1 | 639 | 2 | 11 | 46 | |
| GSE47630 | PRDM1 | 639 | 9 | 4 | 27 | |
| GSE54993 | PRDM1 | 639 | 3 | 2 | 65 | |
| GSE54994 | PRDM1 | 639 | 8 | 8 | 37 | |
| GSE60625 | PRDM1 | 639 | 0 | 2 | 9 | |
| GSE74703 | PRDM1 | 639 | 2 | 1 | 33 | |
| GSE74704 | PRDM1 | 639 | 1 | 0 | 19 | |
| TCGA | PRDM1 | 639 | 5 | 24 | 67 |
Total number of gains: 39; Total number of losses: 58; Total Number of normals: 391.
Somatic mutations of PRDM1:
Generating mutation plots.
Highly correlated genes for PRDM1:
Showing top 20/1432 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRDM1 | SULT2B1 | 0.823049 | 9 | 0 | 9 |
| PRDM1 | PRSS3 | 0.816388 | 11 | 0 | 11 |
| PRDM1 | TMPRSS11E | 0.813045 | 11 | 0 | 11 |
| PRDM1 | CNFN | 0.813045 | 7 | 0 | 7 |
| PRDM1 | ARAP2 | 0.809019 | 3 | 0 | 3 |
| PRDM1 | CYSRT1 | 0.808877 | 6 | 0 | 6 |
| PRDM1 | TGM1 | 0.806409 | 11 | 0 | 11 |
| PRDM1 | EPS8L1 | 0.805837 | 11 | 0 | 11 |
| PRDM1 | PADI1 | 0.802114 | 8 | 0 | 8 |
| PRDM1 | MALL | 0.800231 | 11 | 0 | 11 |
| PRDM1 | SLURP1 | 0.800093 | 10 | 0 | 10 |
| PRDM1 | MPZL3 | 0.799885 | 7 | 0 | 6 |
| PRDM1 | LYNX1 | 0.799015 | 6 | 0 | 6 |
| PRDM1 | EVPL | 0.796272 | 11 | 0 | 11 |
| PRDM1 | ARHGAP27 | 0.795981 | 7 | 0 | 7 |
| PRDM1 | TMOD3 | 0.792159 | 11 | 0 | 11 |
| PRDM1 | GDPD3 | 0.791382 | 11 | 0 | 10 |
| PRDM1 | SPNS2 | 0.791179 | 5 | 0 | 5 |
| PRDM1 | PRSS2 | 0.79091 | 9 | 0 | 9 |
| PRDM1 | MXD1 | 0.790589 | 12 | 0 | 10 |
For details and further investigation, click here
