PLD1

 

Full name: phospholipase D1 Alias Symbol: 
Type: protein-coding gene Cytoband: 3q26.31
Entrez ID: 5337 HGNC ID: HGNC:9067 Ensembl Gene: ENSG00000075651 OMIM ID: 602382
Drug and gene relationship at DGIdb

 

PLD1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04024cAMP signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04724Glutamatergic synapse
hsa04912GnRH signaling pathway
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of PLD1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PLD1 5337 226636_at -0.9210 0.1162
GSE20347 PLD1 5337 205203_at -1.1313 0.0000
GSE23400 PLD1 5337 205203_at -0.6406 0.0000
GSE26886 PLD1 5337 205203_at -1.3574 0.0000
GSE29001 PLD1 5337 205203_at -1.3591 0.0004
GSE38129 PLD1 5337 205203_at -0.7180 0.0159
GSE45670 PLD1 5337 226636_at -0.4647 0.1340
GSE53622 PLD1 5337 51302 -1.0644 0.0000
GSE53624 PLD1 5337 51302 -1.4425 0.0000
GSE63941 PLD1 5337 226636_at -0.6507 0.3990
GSE77861 PLD1 5337 205203_at -0.9688 0.0042
GSE97050 PLD1 5337 A_33_P3320062 -0.0076 0.9855
SRP007169 PLD1 5337 RNAseq -0.4379 0.3652
SRP008496 PLD1 5337 RNAseq -0.5097 0.1201
SRP064894 PLD1 5337 RNAseq -1.1530 0.0000
SRP133303 PLD1 5337 RNAseq -0.7911 0.0004
SRP159526 PLD1 5337 RNAseq -1.2406 0.0249
SRP193095 PLD1 5337 RNAseq -1.2866 0.0000
SRP219564 PLD1 5337 RNAseq -0.9348 0.1860
TCGA PLD1 5337 RNAseq 0.1947 0.0163

Upregulated datasets: 0; Downregulated datasets: 8.  

 

Survival by PLD1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PLD1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PLD1 5337 23 0 7
GSE20123 PLD1 5337 23 0 7
GSE43470 PLD1 5337 23 0 20
GSE46452 PLD1 5337 19 1 39
GSE47630 PLD1 5337 27 2 11
GSE54993 PLD1 5337 1 15 54
GSE54994 PLD1 5337 41 0 12
GSE60625 PLD1 5337 0 6 5
GSE74703 PLD1 5337 19 0 17
GSE74704 PLD1 5337 15 0 5
TCGA PLD1 5337 80 0 16

Total number of gains: 271; Total number of losses: 24; Total Number of normals: 193.  

 

Somatic mutations of PLD1:

 

Generating mutation plots.

 

Highly correlated genes for PLD1:

 

Showing top 20/1897 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PLD1EPHA10.82443510010
PLD1ARHGAP270.81571707
PLD1CAPNS20.809965505
PLD1NEBL0.80634510010
PLD1SFTA20.802878404
PLD1SASH10.8016611011
PLD1RAB11A0.79740611011
PLD1ZNF1850.79473211010
PLD1RAET1E0.793344606
PLD1TMEM400.7925211011
PLD1MALL0.79103210010
PLD1ZDHHC130.78955511011
PLD1RNF1410.78906611011
PLD1ACPP0.7875611010
PLD1SLC16A60.78632511011
PLD1GLTP0.785959909
PLD1ABHD50.78524311011
PLD1MPZL30.784775707
PLD1SCEL0.78459510010
PLD1RAB250.78436211011

For details and further investigation, click here