| Full name: unc-5 netrin receptor B | Alias Symbol: UNC5H2|p53RDL1 | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 219699 | HGNC ID: HGNC:12568 | Ensembl Gene: ENSG00000107731 | OMIM ID: 607870 |
| Drug and gene relationship at DGIdb | |||
UNC5B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of UNC5B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UNC5B | 219699 | 226899_at | 0.3747 | 0.5650 | |
| GSE20347 | UNC5B | 219699 | 41856_at | -0.1854 | 0.0786 | |
| GSE23400 | UNC5B | 219699 | 41856_at | -0.0621 | 0.1507 | |
| GSE26886 | UNC5B | 219699 | 41856_at | -0.7489 | 0.0000 | |
| GSE29001 | UNC5B | 219699 | 41856_at | -0.1500 | 0.6934 | |
| GSE38129 | UNC5B | 219699 | 41856_at | -0.1412 | 0.2585 | |
| GSE45670 | UNC5B | 219699 | 226899_at | 0.1439 | 0.4879 | |
| GSE53622 | UNC5B | 219699 | 28688 | -0.0172 | 0.9148 | |
| GSE53624 | UNC5B | 219699 | 28688 | -0.1700 | 0.0270 | |
| GSE63941 | UNC5B | 219699 | 226899_at | 1.0764 | 0.4208 | |
| GSE77861 | UNC5B | 219699 | 41856_at | -0.1366 | 0.2558 | |
| GSE97050 | UNC5B | 219699 | A_23_P52336 | 0.6625 | 0.1386 | |
| SRP007169 | UNC5B | 219699 | RNAseq | -0.5205 | 0.3636 | |
| SRP008496 | UNC5B | 219699 | RNAseq | -0.4127 | 0.2022 | |
| SRP064894 | UNC5B | 219699 | RNAseq | 0.1378 | 0.6310 | |
| SRP133303 | UNC5B | 219699 | RNAseq | 0.5081 | 0.0405 | |
| SRP159526 | UNC5B | 219699 | RNAseq | -0.3853 | 0.3123 | |
| SRP193095 | UNC5B | 219699 | RNAseq | 0.2565 | 0.2183 | |
| SRP219564 | UNC5B | 219699 | RNAseq | 0.2888 | 0.7110 | |
| TCGA | UNC5B | 219699 | RNAseq | 0.1376 | 0.1231 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UNC5B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UNC5B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UNC5B | 219699 | 2 | 4 | 24 | |
| GSE20123 | UNC5B | 219699 | 2 | 3 | 25 | |
| GSE43470 | UNC5B | 219699 | 1 | 7 | 35 | |
| GSE46452 | UNC5B | 219699 | 0 | 11 | 48 | |
| GSE47630 | UNC5B | 219699 | 2 | 14 | 24 | |
| GSE54993 | UNC5B | 219699 | 7 | 0 | 63 | |
| GSE54994 | UNC5B | 219699 | 2 | 11 | 40 | |
| GSE60625 | UNC5B | 219699 | 0 | 0 | 11 | |
| GSE74703 | UNC5B | 219699 | 1 | 4 | 31 | |
| GSE74704 | UNC5B | 219699 | 1 | 1 | 18 | |
| TCGA | UNC5B | 219699 | 12 | 22 | 62 |
Total number of gains: 30; Total number of losses: 77; Total Number of normals: 381.
Somatic mutations of UNC5B:
Generating mutation plots.
Highly correlated genes for UNC5B:
Showing top 20/697 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UNC5B | NAT1 | 0.800606 | 3 | 0 | 3 |
| UNC5B | WBP2 | 0.790102 | 3 | 0 | 3 |
| UNC5B | PNPLA6 | 0.774745 | 3 | 0 | 3 |
| UNC5B | RNF149 | 0.76399 | 4 | 0 | 4 |
| UNC5B | BAIAP2L1 | 0.760425 | 3 | 0 | 3 |
| UNC5B | FAM83B | 0.75323 | 3 | 0 | 3 |
| UNC5B | MRPL37 | 0.749196 | 3 | 0 | 3 |
| UNC5B | SLC10A7 | 0.739405 | 3 | 0 | 3 |
| UNC5B | AASDHPPT | 0.737941 | 3 | 0 | 3 |
| UNC5B | ELP4 | 0.730212 | 3 | 0 | 3 |
| UNC5B | AP2S1 | 0.728661 | 4 | 0 | 4 |
| UNC5B | ARFGAP2 | 0.728535 | 3 | 0 | 3 |
| UNC5B | ZFC3H1 | 0.728153 | 4 | 0 | 4 |
| UNC5B | EAF1 | 0.724145 | 3 | 0 | 3 |
| UNC5B | SLC25A39 | 0.715078 | 5 | 0 | 5 |
| UNC5B | SLCO2B1 | 0.708299 | 3 | 0 | 3 |
| UNC5B | ACIN1 | 0.707177 | 3 | 0 | 3 |
| UNC5B | WNK1 | 0.706893 | 4 | 0 | 3 |
| UNC5B | VCPIP1 | 0.704542 | 3 | 0 | 3 |
| UNC5B | SRD5A3 | 0.7043 | 4 | 0 | 3 |
For details and further investigation, click here
