| Full name: bromodomain containing 8 | Alias Symbol: SMAP|p120 | ||
| Type: protein-coding gene | Cytoband: 5q31.2 | ||
| Entrez ID: 10902 | HGNC ID: HGNC:19874 | Ensembl Gene: ENSG00000112983 | OMIM ID: 602848 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BRD8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRD8 | 10902 | 202227_s_at | -0.3849 | 0.2578 | |
| GSE20347 | BRD8 | 10902 | 202227_s_at | 0.2414 | 0.1608 | |
| GSE23400 | BRD8 | 10902 | 202227_s_at | -0.0254 | 0.7568 | |
| GSE26886 | BRD8 | 10902 | 202227_s_at | -0.0599 | 0.8271 | |
| GSE29001 | BRD8 | 10902 | 202227_s_at | 0.0547 | 0.8238 | |
| GSE38129 | BRD8 | 10902 | 202227_s_at | 0.1227 | 0.4054 | |
| GSE45670 | BRD8 | 10902 | 202227_s_at | 0.0805 | 0.7149 | |
| GSE53622 | BRD8 | 10902 | 7222 | -0.2651 | 0.0004 | |
| GSE53624 | BRD8 | 10902 | 7222 | -0.1958 | 0.0005 | |
| GSE63941 | BRD8 | 10902 | 202227_s_at | -0.3154 | 0.4560 | |
| GSE77861 | BRD8 | 10902 | 202227_s_at | -0.1364 | 0.6412 | |
| GSE97050 | BRD8 | 10902 | A_23_P145016 | -0.2395 | 0.4245 | |
| SRP007169 | BRD8 | 10902 | RNAseq | 0.2594 | 0.6197 | |
| SRP064894 | BRD8 | 10902 | RNAseq | -0.1903 | 0.2192 | |
| SRP133303 | BRD8 | 10902 | RNAseq | 0.4319 | 0.1233 | |
| SRP159526 | BRD8 | 10902 | RNAseq | 0.1672 | 0.6373 | |
| SRP193095 | BRD8 | 10902 | RNAseq | -0.1002 | 0.3796 | |
| SRP219564 | BRD8 | 10902 | RNAseq | 0.0026 | 0.9941 | |
| TCGA | BRD8 | 10902 | RNAseq | -0.0320 | 0.5276 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BRD8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRD8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRD8 | 10902 | 3 | 10 | 17 | |
| GSE20123 | BRD8 | 10902 | 4 | 10 | 16 | |
| GSE43470 | BRD8 | 10902 | 4 | 5 | 34 | |
| GSE46452 | BRD8 | 10902 | 0 | 27 | 32 | |
| GSE47630 | BRD8 | 10902 | 0 | 21 | 19 | |
| GSE54993 | BRD8 | 10902 | 9 | 1 | 60 | |
| GSE54994 | BRD8 | 10902 | 3 | 13 | 37 | |
| GSE60625 | BRD8 | 10902 | 0 | 0 | 11 | |
| GSE74703 | BRD8 | 10902 | 3 | 4 | 29 | |
| GSE74704 | BRD8 | 10902 | 3 | 4 | 13 | |
| TCGA | BRD8 | 10902 | 4 | 36 | 56 |
Total number of gains: 33; Total number of losses: 131; Total Number of normals: 324.
Somatic mutations of BRD8:
Generating mutation plots.
Highly correlated genes for BRD8:
Showing top 20/162 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRD8 | ZNF227 | 0.820259 | 3 | 0 | 3 |
| BRD8 | ZNF292 | 0.782243 | 3 | 0 | 3 |
| BRD8 | UPF3A | 0.756153 | 3 | 0 | 3 |
| BRD8 | MED7 | 0.754417 | 4 | 0 | 4 |
| BRD8 | ZNF394 | 0.742408 | 3 | 0 | 3 |
| BRD8 | HCFC2 | 0.737533 | 3 | 0 | 3 |
| BRD8 | STAM2 | 0.729231 | 3 | 0 | 3 |
| BRD8 | NUB1 | 0.726467 | 3 | 0 | 3 |
| BRD8 | SCAF8 | 0.726048 | 3 | 0 | 3 |
| BRD8 | CBFA2T2 | 0.724729 | 3 | 0 | 3 |
| BRD8 | YPEL2 | 0.720716 | 3 | 0 | 3 |
| BRD8 | DCUN1D4 | 0.718052 | 3 | 0 | 3 |
| BRD8 | TET2 | 0.709246 | 3 | 0 | 3 |
| BRD8 | SRSF11 | 0.701989 | 3 | 0 | 3 |
| BRD8 | ZNF419 | 0.6989 | 4 | 0 | 4 |
| BRD8 | APPBP2 | 0.696991 | 3 | 0 | 3 |
| BRD8 | PPP2CA | 0.69668 | 3 | 0 | 3 |
| BRD8 | EPG5 | 0.692863 | 3 | 0 | 3 |
| BRD8 | PAIP2 | 0.690898 | 4 | 0 | 3 |
| BRD8 | AFF1 | 0.690366 | 3 | 0 | 3 |
For details and further investigation, click here
