| Full name: zinc finger protein 274 | Alias Symbol: ZKSCAN19|ZSCAN51 | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 10782 | HGNC ID: HGNC:13068 | Ensembl Gene: ENSG00000171606 | OMIM ID: 605467 |
| Drug and gene relationship at DGIdb | |||
ZNF274 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04722 | Neurotrophin signaling pathway |
Expression of ZNF274:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZNF274 | 10782 | 204937_s_at | -0.1251 | 0.8840 | |
| GSE20347 | ZNF274 | 10782 | 204937_s_at | -0.5349 | 0.0009 | |
| GSE23400 | ZNF274 | 10782 | 204937_s_at | -0.3562 | 0.0000 | |
| GSE26886 | ZNF274 | 10782 | 204937_s_at | -0.5996 | 0.0142 | |
| GSE29001 | ZNF274 | 10782 | 204937_s_at | -0.3701 | 0.3465 | |
| GSE38129 | ZNF274 | 10782 | 204937_s_at | -0.5519 | 0.0000 | |
| GSE45670 | ZNF274 | 10782 | 204937_s_at | -0.2084 | 0.3084 | |
| GSE53622 | ZNF274 | 10782 | 10476 | -0.4171 | 0.0000 | |
| GSE53624 | ZNF274 | 10782 | 10476 | -0.6302 | 0.0000 | |
| GSE63941 | ZNF274 | 10782 | 204937_s_at | 1.1971 | 0.0265 | |
| GSE77861 | ZNF274 | 10782 | 204937_s_at | -0.8142 | 0.0179 | |
| GSE97050 | ZNF274 | 10782 | A_23_P153251 | 0.0110 | 0.9795 | |
| SRP007169 | ZNF274 | 10782 | RNAseq | -1.8195 | 0.0001 | |
| SRP008496 | ZNF274 | 10782 | RNAseq | -1.6029 | 0.0000 | |
| SRP064894 | ZNF274 | 10782 | RNAseq | -0.6024 | 0.0029 | |
| SRP133303 | ZNF274 | 10782 | RNAseq | -0.5352 | 0.0198 | |
| SRP159526 | ZNF274 | 10782 | RNAseq | -0.4854 | 0.1553 | |
| SRP193095 | ZNF274 | 10782 | RNAseq | -0.6242 | 0.0000 | |
| SRP219564 | ZNF274 | 10782 | RNAseq | -0.7072 | 0.0994 | |
| TCGA | ZNF274 | 10782 | RNAseq | -0.1674 | 0.0074 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by ZNF274 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZNF274:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZNF274 | 10782 | 2 | 4 | 24 | |
| GSE20123 | ZNF274 | 10782 | 2 | 3 | 25 | |
| GSE43470 | ZNF274 | 10782 | 3 | 9 | 31 | |
| GSE46452 | ZNF274 | 10782 | 45 | 1 | 13 | |
| GSE47630 | ZNF274 | 10782 | 8 | 6 | 26 | |
| GSE54993 | ZNF274 | 10782 | 18 | 4 | 48 | |
| GSE54994 | ZNF274 | 10782 | 5 | 12 | 36 | |
| GSE60625 | ZNF274 | 10782 | 9 | 0 | 2 | |
| GSE74703 | ZNF274 | 10782 | 3 | 6 | 27 | |
| GSE74704 | ZNF274 | 10782 | 2 | 1 | 17 | |
| TCGA | ZNF274 | 10782 | 20 | 17 | 59 |
Total number of gains: 117; Total number of losses: 63; Total Number of normals: 308.
Somatic mutations of ZNF274:
Generating mutation plots.
Highly correlated genes for ZNF274:
Showing top 20/713 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZNF274 | C2orf76 | 0.781636 | 4 | 0 | 4 |
| ZNF274 | AKAP17A | 0.779192 | 3 | 0 | 3 |
| ZNF274 | KCTD15 | 0.771936 | 3 | 0 | 3 |
| ZNF274 | COG3 | 0.759071 | 4 | 0 | 4 |
| ZNF274 | PPIP5K2 | 0.751066 | 4 | 0 | 4 |
| ZNF274 | ADCK1 | 0.748153 | 3 | 0 | 3 |
| ZNF274 | ZNF879 | 0.747349 | 4 | 0 | 4 |
| ZNF274 | TBRG1 | 0.746817 | 3 | 0 | 3 |
| ZNF274 | RAP2C | 0.738913 | 3 | 0 | 3 |
| ZNF274 | FBXO32 | 0.737009 | 3 | 0 | 3 |
| ZNF274 | EIF5B | 0.715525 | 3 | 0 | 3 |
| ZNF274 | UPF3A | 0.71196 | 4 | 0 | 4 |
| ZNF274 | NAPG | 0.711361 | 3 | 0 | 3 |
| ZNF274 | TPP2 | 0.709857 | 4 | 0 | 3 |
| ZNF274 | MKLN1 | 0.705038 | 3 | 0 | 3 |
| ZNF274 | CDC16 | 0.697211 | 4 | 0 | 4 |
| ZNF274 | ZNF416 | 0.690015 | 5 | 0 | 4 |
| ZNF274 | DNAJB6 | 0.689912 | 3 | 0 | 3 |
| ZNF274 | GIMAP6 | 0.687327 | 3 | 0 | 3 |
| ZNF274 | SNX14 | 0.686866 | 3 | 0 | 3 |
For details and further investigation, click here
