| Full name: uroporphyrinogen III synthase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 10q26.2 | ||
| Entrez ID: 7390 | HGNC ID: HGNC:12592 | Ensembl Gene: ENSG00000188690 | OMIM ID: 606938 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of UROS:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UROS | 7390 | 203031_s_at | 0.4861 | 0.2105 | |
| GSE20347 | UROS | 7390 | 203031_s_at | -0.0193 | 0.9334 | |
| GSE23400 | UROS | 7390 | 203031_s_at | -0.0087 | 0.8990 | |
| GSE26886 | UROS | 7390 | 203031_s_at | -0.3005 | 0.2231 | |
| GSE29001 | UROS | 7390 | 203031_s_at | -0.0287 | 0.9408 | |
| GSE38129 | UROS | 7390 | 203031_s_at | -0.0471 | 0.7809 | |
| GSE45670 | UROS | 7390 | 203031_s_at | 0.0881 | 0.6267 | |
| GSE53622 | UROS | 7390 | 19419 | 0.0816 | 0.1888 | |
| GSE53624 | UROS | 7390 | 19419 | 0.1529 | 0.0356 | |
| GSE63941 | UROS | 7390 | 203031_s_at | -1.0840 | 0.0361 | |
| GSE77861 | UROS | 7390 | 203031_s_at | -0.0226 | 0.9522 | |
| GSE97050 | UROS | 7390 | A_33_P3233565 | -0.0036 | 0.9898 | |
| SRP007169 | UROS | 7390 | RNAseq | -0.6732 | 0.0882 | |
| SRP008496 | UROS | 7390 | RNAseq | -0.3067 | 0.2977 | |
| SRP064894 | UROS | 7390 | RNAseq | 0.5912 | 0.0632 | |
| SRP133303 | UROS | 7390 | RNAseq | 0.2014 | 0.0187 | |
| SRP159526 | UROS | 7390 | RNAseq | 0.1775 | 0.5129 | |
| SRP193095 | UROS | 7390 | RNAseq | -0.1525 | 0.2105 | |
| SRP219564 | UROS | 7390 | RNAseq | 0.2528 | 0.5989 | |
| TCGA | UROS | 7390 | RNAseq | -0.1327 | 0.0397 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by UROS expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UROS:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UROS | 7390 | 2 | 6 | 22 | |
| GSE20123 | UROS | 7390 | 2 | 6 | 22 | |
| GSE43470 | UROS | 7390 | 0 | 10 | 33 | |
| GSE46452 | UROS | 7390 | 0 | 11 | 48 | |
| GSE47630 | UROS | 7390 | 2 | 14 | 24 | |
| GSE54993 | UROS | 7390 | 8 | 1 | 61 | |
| GSE54994 | UROS | 7390 | 1 | 9 | 43 | |
| GSE60625 | UROS | 7390 | 0 | 0 | 11 | |
| GSE74703 | UROS | 7390 | 0 | 6 | 30 | |
| GSE74704 | UROS | 7390 | 2 | 2 | 16 | |
| TCGA | UROS | 7390 | 7 | 27 | 62 |
Total number of gains: 24; Total number of losses: 92; Total Number of normals: 372.
Somatic mutations of UROS:
Generating mutation plots.
Highly correlated genes for UROS:
Showing top 20/454 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UROS | NDUFA11 | 0.834018 | 3 | 0 | 3 |
| UROS | DVL3 | 0.802851 | 3 | 0 | 3 |
| UROS | NIPAL3 | 0.791567 | 3 | 0 | 3 |
| UROS | DNASE2 | 0.784136 | 3 | 0 | 3 |
| UROS | UPF1 | 0.769791 | 3 | 0 | 3 |
| UROS | SLC39A13 | 0.767457 | 3 | 0 | 3 |
| UROS | TXLNA | 0.764346 | 3 | 0 | 3 |
| UROS | C6orf136 | 0.750018 | 3 | 0 | 3 |
| UROS | CERS5 | 0.746591 | 3 | 0 | 3 |
| UROS | UQCR11 | 0.74389 | 3 | 0 | 3 |
| UROS | KIAA2013 | 0.728473 | 3 | 0 | 3 |
| UROS | PSMG2 | 0.728301 | 3 | 0 | 3 |
| UROS | WDR1 | 0.727392 | 3 | 0 | 3 |
| UROS | GNA11 | 0.72487 | 4 | 0 | 4 |
| UROS | ZNF672 | 0.723183 | 4 | 0 | 3 |
| UROS | RUNDC1 | 0.722897 | 3 | 0 | 3 |
| UROS | FAM53B | 0.722658 | 4 | 0 | 3 |
| UROS | ZNF791 | 0.721811 | 3 | 0 | 3 |
| UROS | CHAMP1 | 0.716142 | 3 | 0 | 3 |
| UROS | EMILIN2 | 0.716128 | 3 | 0 | 3 |
For details and further investigation, click here
