DVL3

 

Full name: dishevelled segment polarity protein 3 Alias Symbol: KIAA0208
Type: protein-coding gene Cytoband: 3q27.1
Entrez ID: 1857 HGNC ID: HGNC:3087 Ensembl Gene: ENSG00000161202 OMIM ID: 601368
Drug and gene relationship at DGIdb

 

DVL3 involved pathways:

KEGG pathway Description View
hsa04150mTOR signaling pathway
hsa04310Wnt signaling pathway
hsa04330Notch signaling pathway
hsa04390Hippo signaling pathway
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma

 

Expression of DVL3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DVL3 1857 201908_at 0.8017 0.1318
GSE20347 DVL3 1857 201908_at 0.8861 0.0000
GSE23400 DVL3 1857 201908_at 0.6996 0.0000
GSE26886 DVL3 1857 201908_at 0.3546 0.2711
GSE29001 DVL3 1857 201908_at 0.9623 0.0007
GSE38129 DVL3 1857 201908_at 0.8439 0.0000
GSE45670 DVL3 1857 201908_at 0.5646 0.0043
GSE53622 DVL3 1857 62632 0.9577 0.0000
GSE53624 DVL3 1857 62632 0.7307 0.0000
GSE63941 DVL3 1857 201908_at -0.0715 0.9124
GSE77861 DVL3 1857 201908_at 1.0686 0.0073
GSE97050 DVL3 1857 A_24_P291588 0.3397 0.2394
SRP007169 DVL3 1857 RNAseq 1.5937 0.0004
SRP008496 DVL3 1857 RNAseq 1.4719 0.0000
SRP064894 DVL3 1857 RNAseq 0.8499 0.0000
SRP133303 DVL3 1857 RNAseq 1.0134 0.0000
SRP159526 DVL3 1857 RNAseq 1.3139 0.0000
SRP193095 DVL3 1857 RNAseq 1.0445 0.0000
SRP219564 DVL3 1857 RNAseq 0.2680 0.2697
TCGA DVL3 1857 RNAseq 0.2050 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by DVL3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DVL3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DVL3 1857 25 0 5
GSE20123 DVL3 1857 25 0 5
GSE43470 DVL3 1857 25 0 18
GSE46452 DVL3 1857 19 1 39
GSE47630 DVL3 1857 27 2 11
GSE54993 DVL3 1857 1 19 50
GSE54994 DVL3 1857 41 0 12
GSE60625 DVL3 1857 0 6 5
GSE74703 DVL3 1857 21 0 15
GSE74704 DVL3 1857 17 0 3
TCGA DVL3 1857 77 0 19

Total number of gains: 278; Total number of losses: 28; Total Number of normals: 182.  

 

Somatic mutations of DVL3:

 

Generating mutation plots.

 

Highly correlated genes for DVL3:

 

Showing top 20/1736 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DVL3UROS0.802851303
DVL3MAP3K130.801404606
DVL3SNAPC20.754104303
DVL3MAGEF10.73641112012
DVL3PYCR20.733206404
DVL3P4HA10.731469505
DVL3ORAI10.729059404
DVL3RNF70.72715311010
DVL3PIGS0.725129303
DVL3PSMD20.72042512012
DVL3UCP20.718931403
DVL3C2CD20.717676303
DVL3ALKBH60.715844403
DVL3TMEM440.715581505
DVL3FAM53B0.713817303
DVL3RNF1660.713012303
DVL3PLXNA10.7129812011
DVL3RHOC0.712134303
DVL3VEGFB0.710043303
DVL3NCBP20.70990912011

For details and further investigation, click here