| Full name: UPF1 RNA helicase and ATPase | Alias Symbol: HUPF1|KIAA0221|NORF1|pNORF1|smg-2 | ||
| Type: protein-coding gene | Cytoband: 19p13.11 | ||
| Entrez ID: 5976 | HGNC ID: HGNC:9962 | Ensembl Gene: ENSG00000005007 | OMIM ID: 601430 |
| Drug and gene relationship at DGIdb | |||
Expression of UPF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UPF1 | 5976 | 211168_s_at | 0.4135 | 0.3206 | |
| GSE20347 | UPF1 | 5976 | 211168_s_at | 0.4180 | 0.0005 | |
| GSE23400 | UPF1 | 5976 | 211168_s_at | 0.2803 | 0.0000 | |
| GSE26886 | UPF1 | 5976 | 211168_s_at | -0.1688 | 0.3381 | |
| GSE29001 | UPF1 | 5976 | 211168_s_at | 0.4613 | 0.1304 | |
| GSE38129 | UPF1 | 5976 | 211168_s_at | 0.3881 | 0.0000 | |
| GSE45670 | UPF1 | 5976 | 211168_s_at | 0.2911 | 0.0044 | |
| GSE53622 | UPF1 | 5976 | 66982 | 0.0269 | 0.6689 | |
| GSE53624 | UPF1 | 5976 | 66982 | 0.4837 | 0.0000 | |
| GSE63941 | UPF1 | 5976 | 211168_s_at | 0.0718 | 0.8218 | |
| GSE77861 | UPF1 | 5976 | 211168_s_at | 0.3884 | 0.0562 | |
| GSE97050 | UPF1 | 5976 | A_24_P194154 | -0.1282 | 0.5801 | |
| SRP007169 | UPF1 | 5976 | RNAseq | 0.6961 | 0.0717 | |
| SRP008496 | UPF1 | 5976 | RNAseq | 0.4791 | 0.0592 | |
| SRP064894 | UPF1 | 5976 | RNAseq | 0.1714 | 0.1920 | |
| SRP133303 | UPF1 | 5976 | RNAseq | 0.1854 | 0.1987 | |
| SRP159526 | UPF1 | 5976 | RNAseq | 0.2283 | 0.3508 | |
| SRP193095 | UPF1 | 5976 | RNAseq | 0.2153 | 0.0348 | |
| SRP219564 | UPF1 | 5976 | RNAseq | 0.5676 | 0.1422 | |
| TCGA | UPF1 | 5976 | RNAseq | -0.0070 | 0.8626 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by UPF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UPF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UPF1 | 5976 | 4 | 5 | 21 | |
| GSE20123 | UPF1 | 5976 | 3 | 3 | 24 | |
| GSE43470 | UPF1 | 5976 | 2 | 5 | 36 | |
| GSE46452 | UPF1 | 5976 | 47 | 1 | 11 | |
| GSE47630 | UPF1 | 5976 | 5 | 8 | 27 | |
| GSE54993 | UPF1 | 5976 | 16 | 4 | 50 | |
| GSE54994 | UPF1 | 5976 | 6 | 13 | 34 | |
| GSE60625 | UPF1 | 5976 | 9 | 0 | 2 | |
| GSE74703 | UPF1 | 5976 | 2 | 3 | 31 | |
| GSE74704 | UPF1 | 5976 | 0 | 3 | 17 | |
| TCGA | UPF1 | 5976 | 16 | 10 | 70 |
Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.
Somatic mutations of UPF1:
Generating mutation plots.
Highly correlated genes for UPF1:
Showing top 20/1010 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UPF1 | DYRK2 | 0.843708 | 3 | 0 | 3 |
| UPF1 | PROSER1 | 0.816324 | 3 | 0 | 3 |
| UPF1 | SCAF4 | 0.81013 | 3 | 0 | 3 |
| UPF1 | KCTD15 | 0.797861 | 3 | 0 | 3 |
| UPF1 | ZNF564 | 0.793718 | 3 | 0 | 3 |
| UPF1 | DMAP1 | 0.788769 | 3 | 0 | 3 |
| UPF1 | MCCC1 | 0.784705 | 3 | 0 | 3 |
| UPF1 | CCDC14 | 0.784105 | 3 | 0 | 3 |
| UPF1 | NDUFA11 | 0.781484 | 3 | 0 | 3 |
| UPF1 | PACSIN3 | 0.775419 | 3 | 0 | 3 |
| UPF1 | SLC26A11 | 0.771362 | 3 | 0 | 3 |
| UPF1 | UROS | 0.769791 | 3 | 0 | 3 |
| UPF1 | RSAD1 | 0.768036 | 3 | 0 | 3 |
| UPF1 | ARL2 | 0.764644 | 3 | 0 | 3 |
| UPF1 | CHD6 | 0.751242 | 3 | 0 | 3 |
| UPF1 | GTPBP6 | 0.747382 | 4 | 0 | 4 |
| UPF1 | LRRC41 | 0.744294 | 3 | 0 | 3 |
| UPF1 | KLHDC3 | 0.739204 | 4 | 0 | 3 |
| UPF1 | C12orf45 | 0.734432 | 3 | 0 | 3 |
| UPF1 | TADA1 | 0.733293 | 3 | 0 | 3 |
For details and further investigation, click here
