| Full name: nuclear receptor binding SET domain protein 1 | Alias Symbol: ARA267|FLJ22263|KMT3B | ||
| Type: protein-coding gene | Cytoband: 5q35.3 | ||
| Entrez ID: 64324 | HGNC ID: HGNC:14234 | Ensembl Gene: ENSG00000165671 | OMIM ID: 606681 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of NSD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSD1 | 64324 | 219084_at | 0.4304 | 0.1723 | |
| GSE20347 | NSD1 | 64324 | 219084_at | -0.1078 | 0.3149 | |
| GSE23400 | NSD1 | 64324 | 219084_at | -0.1035 | 0.0213 | |
| GSE26886 | NSD1 | 64324 | 219084_at | 0.2157 | 0.1893 | |
| GSE29001 | NSD1 | 64324 | 219084_at | -0.0239 | 0.8922 | |
| GSE38129 | NSD1 | 64324 | 219084_at | -0.1117 | 0.1902 | |
| GSE45670 | NSD1 | 64324 | 219084_at | 0.2216 | 0.0531 | |
| GSE53622 | NSD1 | 64324 | 82581 | -0.2361 | 0.0005 | |
| GSE53624 | NSD1 | 64324 | 82581 | -0.1594 | 0.0010 | |
| GSE63941 | NSD1 | 64324 | 219084_at | 0.4799 | 0.2069 | |
| GSE77861 | NSD1 | 64324 | 219084_at | -0.0575 | 0.7478 | |
| GSE97050 | NSD1 | 64324 | A_23_P124327 | -0.2481 | 0.2666 | |
| SRP007169 | NSD1 | 64324 | RNAseq | 0.2519 | 0.6385 | |
| SRP008496 | NSD1 | 64324 | RNAseq | 0.1020 | 0.7294 | |
| SRP064894 | NSD1 | 64324 | RNAseq | -0.2710 | 0.1559 | |
| SRP133303 | NSD1 | 64324 | RNAseq | -0.1541 | 0.1915 | |
| SRP159526 | NSD1 | 64324 | RNAseq | -0.1256 | 0.7403 | |
| SRP193095 | NSD1 | 64324 | RNAseq | -0.0462 | 0.6461 | |
| SRP219564 | NSD1 | 64324 | RNAseq | -0.0878 | 0.7342 | |
| TCGA | NSD1 | 64324 | RNAseq | 0.0239 | 0.5952 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by NSD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of NSD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSD1 | 64324 | 2 | 13 | 15 | |
| GSE20123 | NSD1 | 64324 | 2 | 13 | 15 | |
| GSE43470 | NSD1 | 64324 | 1 | 11 | 31 | |
| GSE46452 | NSD1 | 64324 | 0 | 27 | 32 | |
| GSE47630 | NSD1 | 64324 | 1 | 20 | 19 | |
| GSE54993 | NSD1 | 64324 | 10 | 2 | 58 | |
| GSE54994 | NSD1 | 64324 | 2 | 17 | 34 | |
| GSE60625 | NSD1 | 64324 | 1 | 0 | 10 | |
| GSE74703 | NSD1 | 64324 | 1 | 7 | 28 | |
| GSE74704 | NSD1 | 64324 | 1 | 6 | 13 | |
| TCGA | NSD1 | 64324 | 8 | 35 | 53 |
Total number of gains: 29; Total number of losses: 151; Total Number of normals: 308.
Somatic mutations of NSD1:
Generating mutation plots.
Highly correlated genes for NSD1:
Showing top 20/279 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSD1 | CASKIN2 | 0.847684 | 3 | 0 | 3 |
| NSD1 | CDC37 | 0.839675 | 3 | 0 | 3 |
| NSD1 | TBCD | 0.818847 | 3 | 0 | 3 |
| NSD1 | FLYWCH2 | 0.815674 | 3 | 0 | 3 |
| NSD1 | RBM15B | 0.794321 | 3 | 0 | 3 |
| NSD1 | UBIAD1 | 0.789638 | 3 | 0 | 3 |
| NSD1 | SF3B2 | 0.789622 | 3 | 0 | 3 |
| NSD1 | MEAF6 | 0.780509 | 3 | 0 | 3 |
| NSD1 | ZNF408 | 0.778959 | 3 | 0 | 3 |
| NSD1 | CRTC2 | 0.772826 | 3 | 0 | 3 |
| NSD1 | BAZ1B | 0.771067 | 3 | 0 | 3 |
| NSD1 | RHBDD2 | 0.764261 | 3 | 0 | 3 |
| NSD1 | ZC3HC1 | 0.763597 | 3 | 0 | 3 |
| NSD1 | MEPCE | 0.762937 | 3 | 0 | 3 |
| NSD1 | EIF2B5 | 0.757671 | 3 | 0 | 3 |
| NSD1 | DDX23 | 0.757557 | 3 | 0 | 3 |
| NSD1 | TRMU | 0.756013 | 3 | 0 | 3 |
| NSD1 | STAU1 | 0.749112 | 3 | 0 | 3 |
| NSD1 | BOLA1 | 0.744352 | 3 | 0 | 3 |
| NSD1 | SLC29A3 | 0.74077 | 3 | 0 | 3 |
For details and further investigation, click here
