| Full name: VPS16 core subunit of CORVET and HOPS complexes | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 64601 | HGNC ID: HGNC:14584 | Ensembl Gene: ENSG00000215305 | OMIM ID: 608550 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VPS16:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VPS16 | 64601 | 203459_s_at | 0.5432 | 0.0429 | |
| GSE20347 | VPS16 | 64601 | 203459_s_at | 0.1667 | 0.1897 | |
| GSE23400 | VPS16 | 64601 | 203459_s_at | 0.3124 | 0.0000 | |
| GSE26886 | VPS16 | 64601 | 203459_s_at | 0.4771 | 0.0523 | |
| GSE29001 | VPS16 | 64601 | 203459_s_at | 0.3415 | 0.2918 | |
| GSE38129 | VPS16 | 64601 | 203459_s_at | 0.2479 | 0.0181 | |
| GSE45670 | VPS16 | 64601 | 203459_s_at | 0.4646 | 0.0012 | |
| GSE53622 | VPS16 | 64601 | 50017 | 0.3772 | 0.0000 | |
| GSE53624 | VPS16 | 64601 | 50017 | 0.2874 | 0.0000 | |
| GSE63941 | VPS16 | 64601 | 203459_s_at | -0.5508 | 0.0898 | |
| GSE77861 | VPS16 | 64601 | 203459_s_at | 0.1701 | 0.2009 | |
| GSE97050 | VPS16 | 64601 | A_23_P143303 | 0.4809 | 0.2147 | |
| SRP007169 | VPS16 | 64601 | RNAseq | 0.1993 | 0.6702 | |
| SRP008496 | VPS16 | 64601 | RNAseq | 0.4835 | 0.1134 | |
| SRP064894 | VPS16 | 64601 | RNAseq | 0.7912 | 0.0000 | |
| SRP133303 | VPS16 | 64601 | RNAseq | 0.1645 | 0.2459 | |
| SRP159526 | VPS16 | 64601 | RNAseq | 0.4221 | 0.0745 | |
| SRP193095 | VPS16 | 64601 | RNAseq | 0.1201 | 0.2241 | |
| SRP219564 | VPS16 | 64601 | RNAseq | 0.5522 | 0.1113 | |
| TCGA | VPS16 | 64601 | RNAseq | -0.0090 | 0.8622 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by VPS16 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VPS16:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VPS16 | 64601 | 12 | 3 | 15 | |
| GSE20123 | VPS16 | 64601 | 13 | 3 | 14 | |
| GSE43470 | VPS16 | 64601 | 10 | 1 | 32 | |
| GSE46452 | VPS16 | 64601 | 26 | 1 | 32 | |
| GSE47630 | VPS16 | 64601 | 18 | 4 | 18 | |
| GSE54993 | VPS16 | 64601 | 2 | 14 | 54 | |
| GSE54994 | VPS16 | 64601 | 24 | 2 | 27 | |
| GSE60625 | VPS16 | 64601 | 0 | 0 | 11 | |
| GSE74703 | VPS16 | 64601 | 9 | 1 | 26 | |
| GSE74704 | VPS16 | 64601 | 8 | 1 | 11 | |
| TCGA | VPS16 | 64601 | 40 | 12 | 44 |
Total number of gains: 162; Total number of losses: 42; Total Number of normals: 284.
Somatic mutations of VPS16:
Generating mutation plots.
Highly correlated genes for VPS16:
Showing top 20/680 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VPS16 | ARL13B | 0.823997 | 3 | 0 | 3 |
| VPS16 | UBA6 | 0.79985 | 3 | 0 | 3 |
| VPS16 | PTPN1 | 0.770554 | 3 | 0 | 3 |
| VPS16 | WIPI1 | 0.75872 | 3 | 0 | 3 |
| VPS16 | RNF149 | 0.75447 | 3 | 0 | 3 |
| VPS16 | NUDT11 | 0.741604 | 3 | 0 | 3 |
| VPS16 | GLOD4 | 0.737879 | 3 | 0 | 3 |
| VPS16 | LITAF | 0.737444 | 4 | 0 | 3 |
| VPS16 | PET117 | 0.736777 | 4 | 0 | 3 |
| VPS16 | EPAS1 | 0.73543 | 3 | 0 | 3 |
| VPS16 | SRRD | 0.733933 | 3 | 0 | 3 |
| VPS16 | ITFG1 | 0.730418 | 3 | 0 | 3 |
| VPS16 | CKLF | 0.724806 | 3 | 0 | 3 |
| VPS16 | SON | 0.721518 | 3 | 0 | 3 |
| VPS16 | PSMB6 | 0.708226 | 3 | 0 | 3 |
| VPS16 | NAA25 | 0.706169 | 3 | 0 | 3 |
| VPS16 | STX18 | 0.705796 | 3 | 0 | 3 |
| VPS16 | KBTBD7 | 0.704431 | 3 | 0 | 3 |
| VPS16 | RICTOR | 0.701942 | 3 | 0 | 3 |
| VPS16 | EXTL3 | 0.699672 | 4 | 0 | 3 |
For details and further investigation, click here
