EXTL3

 

Full name: exostosin like glycosyltransferase 3 Alias Symbol: botv|REGR
Type: protein-coding gene Cytoband: 8p21.1
Entrez ID: 2137 HGNC ID: HGNC:3518 Ensembl Gene: ENSG00000012232 OMIM ID: 605744
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of EXTL3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EXTL3 2137 209202_s_at 0.7979 0.0445
GSE20347 EXTL3 2137 209202_s_at 0.4177 0.0000
GSE23400 EXTL3 2137 209202_s_at 0.0990 0.0445
GSE26886 EXTL3 2137 209202_s_at 0.3872 0.0110
GSE29001 EXTL3 2137 209202_s_at 0.4935 0.0517
GSE38129 EXTL3 2137 209202_s_at 0.2273 0.0579
GSE45670 EXTL3 2137 209202_s_at 0.5128 0.0002
GSE53622 EXTL3 2137 29718 0.4106 0.0000
GSE53624 EXTL3 2137 29718 0.6105 0.0000
GSE63941 EXTL3 2137 211051_s_at 0.3178 0.2818
GSE77861 EXTL3 2137 209202_s_at 0.1900 0.3618
GSE97050 EXTL3 2137 A_33_P3291294 0.2756 0.3964
SRP007169 EXTL3 2137 RNAseq 0.6229 0.1211
SRP008496 EXTL3 2137 RNAseq 0.7140 0.0277
SRP064894 EXTL3 2137 RNAseq 1.2309 0.0002
SRP133303 EXTL3 2137 RNAseq 0.4224 0.0590
SRP159526 EXTL3 2137 RNAseq 0.8822 0.0267
SRP193095 EXTL3 2137 RNAseq 0.9503 0.0000
SRP219564 EXTL3 2137 RNAseq 0.2942 0.5713
TCGA EXTL3 2137 RNAseq 0.0345 0.5858

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by EXTL3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EXTL3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EXTL3 2137 4 10 16
GSE20123 EXTL3 2137 4 10 16
GSE43470 EXTL3 2137 4 7 32
GSE46452 EXTL3 2137 13 13 33
GSE47630 EXTL3 2137 10 8 22
GSE54993 EXTL3 2137 2 15 53
GSE54994 EXTL3 2137 10 15 28
GSE60625 EXTL3 2137 3 0 8
GSE74703 EXTL3 2137 4 6 26
GSE74704 EXTL3 2137 3 7 10
TCGA EXTL3 2137 17 42 37

Total number of gains: 74; Total number of losses: 133; Total Number of normals: 281.  

 

Somatic mutations of EXTL3:

 

Generating mutation plots.

 

Highly correlated genes for EXTL3:

 

Showing top 20/1411 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EXTL3CCDC1270.747583303
EXTL3POLR2J0.728964303
EXTL3MEX3B0.72833404
EXTL3MED100.725697403
EXTL3STK17A0.7245505
EXTL3CENPBD10.723859404
EXTL3ZSCAN210.723019303
EXTL3KIAA15860.715304303
EXTL3CCM20.714763606
EXTL3SHCBP10.712494505
EXTL3POLR2A0.707716303
EXTL3CYP27C10.705628504
EXTL3TNFRSF210.704233404
EXTL3CPT1C0.704082504
EXTL3TRAF70.703474404
EXTL3DDX180.699969303
EXTL3VPS160.699672403
EXTL3FADS10.696897303
EXTL3TRMT60.694498404
EXTL3CXCL160.691523303

For details and further investigation, click here