| Full name: proteasome subunit beta 6 | Alias Symbol: Y|DELTA | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 5694 | HGNC ID: HGNC:9543 | Ensembl Gene: ENSG00000142507 | OMIM ID: 600307 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PSMB6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMB6 | 5694 | 208827_at | 0.2027 | 0.3797 | |
| GSE20347 | PSMB6 | 5694 | 208827_at | 0.0421 | 0.8228 | |
| GSE23400 | PSMB6 | 5694 | 208827_at | 0.2374 | 0.0022 | |
| GSE26886 | PSMB6 | 5694 | 208827_at | -0.2214 | 0.2435 | |
| GSE29001 | PSMB6 | 5694 | 208827_at | -0.1548 | 0.7158 | |
| GSE38129 | PSMB6 | 5694 | 208827_at | 0.2816 | 0.0786 | |
| GSE45670 | PSMB6 | 5694 | 208827_at | 0.1901 | 0.1717 | |
| GSE53622 | PSMB6 | 5694 | 10508 | -0.1083 | 0.0792 | |
| GSE53624 | PSMB6 | 5694 | 10508 | 0.2069 | 0.0001 | |
| GSE63941 | PSMB6 | 5694 | 208827_at | -0.1348 | 0.7742 | |
| GSE77861 | PSMB6 | 5694 | 208827_at | 0.2801 | 0.0703 | |
| GSE97050 | PSMB6 | 5694 | A_23_P15705 | 0.1247 | 0.5321 | |
| SRP007169 | PSMB6 | 5694 | RNAseq | -0.5100 | 0.1357 | |
| SRP008496 | PSMB6 | 5694 | RNAseq | -0.6724 | 0.0010 | |
| SRP064894 | PSMB6 | 5694 | RNAseq | 0.3741 | 0.1896 | |
| SRP133303 | PSMB6 | 5694 | RNAseq | -0.0052 | 0.9702 | |
| SRP159526 | PSMB6 | 5694 | RNAseq | 0.2430 | 0.1185 | |
| SRP193095 | PSMB6 | 5694 | RNAseq | -0.0192 | 0.9045 | |
| SRP219564 | PSMB6 | 5694 | RNAseq | 0.2315 | 0.4692 | |
| TCGA | PSMB6 | 5694 | RNAseq | 0.1398 | 0.0061 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSMB6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMB6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMB6 | 5694 | 5 | 2 | 23 | |
| GSE20123 | PSMB6 | 5694 | 5 | 3 | 22 | |
| GSE43470 | PSMB6 | 5694 | 1 | 6 | 36 | |
| GSE46452 | PSMB6 | 5694 | 34 | 1 | 24 | |
| GSE47630 | PSMB6 | 5694 | 7 | 1 | 32 | |
| GSE54993 | PSMB6 | 5694 | 4 | 3 | 63 | |
| GSE54994 | PSMB6 | 5694 | 5 | 9 | 39 | |
| GSE60625 | PSMB6 | 5694 | 4 | 0 | 7 | |
| GSE74703 | PSMB6 | 5694 | 1 | 3 | 32 | |
| GSE74704 | PSMB6 | 5694 | 3 | 1 | 16 | |
| TCGA | PSMB6 | 5694 | 19 | 21 | 56 |
Total number of gains: 88; Total number of losses: 50; Total Number of normals: 350.
Somatic mutations of PSMB6:
Generating mutation plots.
Highly correlated genes for PSMB6:
Showing top 20/496 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMB6 | MCOLN1 | 0.804724 | 3 | 0 | 3 |
| PSMB6 | GMEB2 | 0.770646 | 3 | 0 | 3 |
| PSMB6 | TAF1C | 0.762371 | 3 | 0 | 3 |
| PSMB6 | CHCHD7 | 0.753953 | 3 | 0 | 3 |
| PSMB6 | SLC45A4 | 0.732063 | 3 | 0 | 3 |
| PSMB6 | DEXI | 0.727145 | 3 | 0 | 3 |
| PSMB6 | VPS16 | 0.708226 | 3 | 0 | 3 |
| PSMB6 | EMC6 | 0.702442 | 8 | 0 | 8 |
| PSMB6 | NFE2L1 | 0.701565 | 3 | 0 | 3 |
| PSMB6 | HNRNPA1 | 0.697709 | 3 | 0 | 3 |
| PSMB6 | DECR1 | 0.697426 | 3 | 0 | 3 |
| PSMB6 | ZNF706 | 0.693258 | 4 | 0 | 4 |
| PSMB6 | POLR3C | 0.687205 | 3 | 0 | 3 |
| PSMB6 | ALS2 | 0.68521 | 4 | 0 | 4 |
| PSMB6 | RPS19BP1 | 0.678866 | 3 | 0 | 3 |
| PSMB6 | PSMA5 | 0.678812 | 6 | 0 | 4 |
| PSMB6 | BAZ1B | 0.678323 | 3 | 0 | 3 |
| PSMB6 | EIF5A | 0.676847 | 6 | 0 | 5 |
| PSMB6 | COQ10B | 0.676841 | 3 | 0 | 3 |
| PSMB6 | UHMK1 | 0.676636 | 3 | 0 | 3 |
For details and further investigation, click here
