PSMD4

 

Full name: proteasome 26S subunit, non-ATPase 4 Alias Symbol: S5A|AF-1|AF|Rpn10
Type: protein-coding gene Cytoband: 1q21.3
Entrez ID: 5710 HGNC ID: HGNC:9561 Ensembl Gene: ENSG00000159352 OMIM ID: 601648
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PSMD4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PSMD4 5710 211609_x_at 0.2764 0.2181
GSE20347 PSMD4 5710 200882_s_at 0.2621 0.0058
GSE23400 PSMD4 5710 211609_x_at 0.3859 0.0000
GSE26886 PSMD4 5710 200882_s_at 0.6567 0.0002
GSE29001 PSMD4 5710 211609_x_at 0.1996 0.5608
GSE38129 PSMD4 5710 211609_x_at 0.3966 0.0024
GSE45670 PSMD4 5710 211609_x_at 0.3085 0.0235
GSE63941 PSMD4 5710 211609_x_at 1.0419 0.0006
GSE77861 PSMD4 5710 211609_x_at 0.7355 0.0015
GSE97050 PSMD4 5710 A_32_P435367 -0.1604 0.5977
SRP007169 PSMD4 5710 RNAseq -0.4729 0.1339
SRP008496 PSMD4 5710 RNAseq -0.1950 0.4212
SRP064894 PSMD4 5710 RNAseq 0.3189 0.1790
SRP133303 PSMD4 5710 RNAseq 0.3535 0.0146
SRP159526 PSMD4 5710 RNAseq 0.7146 0.0001
SRP193095 PSMD4 5710 RNAseq 0.2986 0.0166
SRP219564 PSMD4 5710 RNAseq 0.0893 0.7648
TCGA PSMD4 5710 RNAseq 0.1435 0.0018

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by PSMD4 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of PSMD4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PSMD4 5710 14 0 16
GSE20123 PSMD4 5710 14 0 16
GSE43470 PSMD4 5710 6 1 36
GSE46452 PSMD4 5710 2 1 56
GSE47630 PSMD4 5710 14 0 26
GSE54993 PSMD4 5710 0 4 66
GSE54994 PSMD4 5710 15 0 38
GSE60625 PSMD4 5710 0 0 11
GSE74703 PSMD4 5710 6 1 29
GSE74704 PSMD4 5710 7 0 13
TCGA PSMD4 5710 37 2 57

Total number of gains: 115; Total number of losses: 9; Total Number of normals: 364.  

 

Somatic mutations of PSMD4:

 

Generating mutation plots.

 

Highly correlated genes for PSMD4:

 

Showing top 20/1386 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PSMD4CPT1A0.772971404
PSMD4MRPS260.751689404
PSMD4KRTCAP20.748325404
PSMD4TMED40.748304303
PSMD4VPS720.7467741009
PSMD4LINC008880.743402303
PSMD4SMARCE10.743247303
PSMD4PRTFDC10.741815404
PSMD4MSTO10.734488404
PSMD4SPOPL0.734105303
PSMD4ZFAND2A0.72888303
PSMD4A4GALT0.727924303
PSMD4DDX200.726438303
PSMD4ALS20.7241403
PSMD4LMO10.721445303
PSMD4C1orf430.72117605
PSMD4ZFP900.718982303
PSMD4CERS20.718702807
PSMD4NTMT10.71052404
PSMD4SORL10.710419303

For details and further investigation, click here