| Full name: ribosomal protein S6 kinase C1 | Alias Symbol: humS6PKh1|RSKL1 | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 26750 | HGNC ID: HGNC:10439 | Ensembl Gene: ENSG00000136643 | OMIM ID: 617517 |
| Drug and gene relationship at DGIdb | |||
Expression of RPS6KC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KC1 | 26750 | 218909_at | 0.5224 | 0.1557 | |
| GSE20347 | RPS6KC1 | 26750 | 218909_at | 0.4469 | 0.0017 | |
| GSE23400 | RPS6KC1 | 26750 | 218909_at | 0.5700 | 0.0000 | |
| GSE26886 | RPS6KC1 | 26750 | 218909_at | 0.0894 | 0.7955 | |
| GSE29001 | RPS6KC1 | 26750 | 218909_at | 0.8477 | 0.0029 | |
| GSE38129 | RPS6KC1 | 26750 | 218909_at | 0.4813 | 0.0014 | |
| GSE45670 | RPS6KC1 | 26750 | 218909_at | 0.4691 | 0.0244 | |
| GSE53622 | RPS6KC1 | 26750 | 17274 | 0.5684 | 0.0000 | |
| GSE53624 | RPS6KC1 | 26750 | 17274 | 0.6057 | 0.0000 | |
| GSE63941 | RPS6KC1 | 26750 | 218909_at | -0.5731 | 0.4556 | |
| GSE77861 | RPS6KC1 | 26750 | 218909_at | 1.1757 | 0.0008 | |
| GSE97050 | RPS6KC1 | 26750 | A_23_P104109 | 0.2016 | 0.4630 | |
| SRP007169 | RPS6KC1 | 26750 | RNAseq | 0.8154 | 0.0575 | |
| SRP008496 | RPS6KC1 | 26750 | RNAseq | 1.0289 | 0.0003 | |
| SRP064894 | RPS6KC1 | 26750 | RNAseq | 0.4709 | 0.0002 | |
| SRP133303 | RPS6KC1 | 26750 | RNAseq | 0.6162 | 0.0000 | |
| SRP159526 | RPS6KC1 | 26750 | RNAseq | 1.0088 | 0.0002 | |
| SRP193095 | RPS6KC1 | 26750 | RNAseq | 0.4453 | 0.0000 | |
| SRP219564 | RPS6KC1 | 26750 | RNAseq | 0.2440 | 0.6069 | |
| TCGA | RPS6KC1 | 26750 | RNAseq | 0.0054 | 0.9217 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by RPS6KC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KC1 | 26750 | 9 | 0 | 21 | |
| GSE20123 | RPS6KC1 | 26750 | 9 | 0 | 21 | |
| GSE43470 | RPS6KC1 | 26750 | 7 | 1 | 35 | |
| GSE46452 | RPS6KC1 | 26750 | 3 | 1 | 55 | |
| GSE47630 | RPS6KC1 | 26750 | 15 | 0 | 25 | |
| GSE54993 | RPS6KC1 | 26750 | 0 | 6 | 64 | |
| GSE54994 | RPS6KC1 | 26750 | 14 | 0 | 39 | |
| GSE60625 | RPS6KC1 | 26750 | 0 | 0 | 11 | |
| GSE74703 | RPS6KC1 | 26750 | 7 | 1 | 28 | |
| GSE74704 | RPS6KC1 | 26750 | 3 | 0 | 17 | |
| TCGA | RPS6KC1 | 26750 | 45 | 3 | 48 |
Total number of gains: 112; Total number of losses: 12; Total Number of normals: 364.
Somatic mutations of RPS6KC1:
Generating mutation plots.
Highly correlated genes for RPS6KC1:
Showing top 20/1765 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KC1 | XAB2 | 0.812193 | 3 | 0 | 3 |
| RPS6KC1 | SLC39A3 | 0.783197 | 3 | 0 | 3 |
| RPS6KC1 | TMEM63B | 0.773951 | 3 | 0 | 3 |
| RPS6KC1 | DESI2 | 0.765127 | 9 | 0 | 9 |
| RPS6KC1 | GNA11 | 0.759259 | 3 | 0 | 3 |
| RPS6KC1 | NAF1 | 0.745062 | 3 | 0 | 3 |
| RPS6KC1 | NACC1 | 0.744835 | 3 | 0 | 3 |
| RPS6KC1 | SPOPL | 0.740602 | 3 | 0 | 3 |
| RPS6KC1 | PYCR2 | 0.739017 | 3 | 0 | 3 |
| RPS6KC1 | COL4A1 | 0.732572 | 8 | 0 | 8 |
| RPS6KC1 | KRTCAP2 | 0.730512 | 4 | 0 | 4 |
| RPS6KC1 | SSBP4 | 0.730007 | 4 | 0 | 3 |
| RPS6KC1 | ZFYVE27 | 0.728099 | 3 | 0 | 3 |
| RPS6KC1 | GORAB | 0.726984 | 7 | 0 | 7 |
| RPS6KC1 | RAB34 | 0.725608 | 3 | 0 | 3 |
| RPS6KC1 | CERS2 | 0.721742 | 8 | 0 | 8 |
| RPS6KC1 | VPS72 | 0.717037 | 10 | 0 | 9 |
| RPS6KC1 | RANBP6 | 0.715388 | 3 | 0 | 3 |
| RPS6KC1 | ZNF664 | 0.714126 | 3 | 0 | 3 |
| RPS6KC1 | SLC15A4 | 0.713558 | 3 | 0 | 3 |
For details and further investigation, click here
