| Full name: WW domain containing adaptor with coiled-coil | Alias Symbol: Wwp4|FLJ31290|PRO1741|BM-016|MGC10753 | ||
| Type: protein-coding gene | Cytoband: 10p12.1 | ||
| Entrez ID: 51322 | HGNC ID: HGNC:17327 | Ensembl Gene: ENSG00000095787 | OMIM ID: 615049 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of WAC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WAC | 51322 | 222390_at | -0.2271 | 0.3181 | |
| GSE20347 | WAC | 51322 | 217742_s_at | -0.1073 | 0.3974 | |
| GSE23400 | WAC | 51322 | 217742_s_at | 0.1632 | 0.0317 | |
| GSE26886 | WAC | 51322 | 222390_at | 0.1687 | 0.2490 | |
| GSE29001 | WAC | 51322 | 217742_s_at | -0.1167 | 0.7241 | |
| GSE38129 | WAC | 51322 | 217742_s_at | -0.2141 | 0.0311 | |
| GSE45670 | WAC | 51322 | 222390_at | -0.2923 | 0.0071 | |
| GSE53622 | WAC | 51322 | 14584 | -0.3572 | 0.0000 | |
| GSE53624 | WAC | 51322 | 14584 | -0.3112 | 0.0000 | |
| GSE63941 | WAC | 51322 | 222390_at | 0.7595 | 0.1301 | |
| GSE77861 | WAC | 51322 | 222390_at | -0.0895 | 0.7013 | |
| GSE97050 | WAC | 51322 | A_23_P201996 | -0.3806 | 0.2151 | |
| SRP007169 | WAC | 51322 | RNAseq | -0.6226 | 0.0851 | |
| SRP008496 | WAC | 51322 | RNAseq | -0.4217 | 0.0637 | |
| SRP064894 | WAC | 51322 | RNAseq | -0.3902 | 0.0070 | |
| SRP133303 | WAC | 51322 | RNAseq | -0.2044 | 0.1640 | |
| SRP159526 | WAC | 51322 | RNAseq | -0.5866 | 0.0103 | |
| SRP193095 | WAC | 51322 | RNAseq | -0.3847 | 0.0000 | |
| SRP219564 | WAC | 51322 | RNAseq | -0.5710 | 0.0570 | |
| TCGA | WAC | 51322 | RNAseq | -0.0718 | 0.0805 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WAC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WAC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WAC | 51322 | 5 | 7 | 18 | |
| GSE20123 | WAC | 51322 | 5 | 6 | 19 | |
| GSE43470 | WAC | 51322 | 3 | 4 | 36 | |
| GSE46452 | WAC | 51322 | 1 | 14 | 44 | |
| GSE47630 | WAC | 51322 | 5 | 15 | 20 | |
| GSE54993 | WAC | 51322 | 9 | 0 | 61 | |
| GSE54994 | WAC | 51322 | 3 | 9 | 41 | |
| GSE60625 | WAC | 51322 | 0 | 0 | 11 | |
| GSE74703 | WAC | 51322 | 2 | 2 | 32 | |
| GSE74704 | WAC | 51322 | 0 | 5 | 15 | |
| TCGA | WAC | 51322 | 19 | 23 | 54 |
Total number of gains: 52; Total number of losses: 85; Total Number of normals: 351.
Somatic mutations of WAC:
Generating mutation plots.
Highly correlated genes for WAC:
Showing top 20/175 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WAC | P2RX2 | 0.724569 | 3 | 0 | 3 |
| WAC | ISOC1 | 0.709206 | 4 | 0 | 3 |
| WAC | MIER1 | 0.679163 | 3 | 0 | 3 |
| WAC | PPP1CB | 0.665432 | 4 | 0 | 4 |
| WAC | C1QTNF7 | 0.651403 | 4 | 0 | 4 |
| WAC | ST6GAL2 | 0.644021 | 4 | 0 | 3 |
| WAC | TATDN1 | 0.630669 | 3 | 0 | 3 |
| WAC | DDX3Y | 0.629373 | 3 | 0 | 3 |
| WAC | FGF14-AS2 | 0.628566 | 3 | 0 | 3 |
| WAC | FOXP1 | 0.623483 | 4 | 0 | 3 |
| WAC | YPEL2 | 0.622356 | 3 | 0 | 3 |
| WAC | MLLT10 | 0.613154 | 9 | 0 | 6 |
| WAC | YME1L1 | 0.609486 | 10 | 0 | 8 |
| WAC | COX20 | 0.605709 | 3 | 0 | 3 |
| WAC | XKR4 | 0.604236 | 4 | 0 | 3 |
| WAC | TSC22D1 | 0.603223 | 3 | 0 | 3 |
| WAC | CAB39L | 0.602641 | 4 | 0 | 3 |
| WAC | BMPR1A | 0.602596 | 6 | 0 | 5 |
| WAC | SOX8 | 0.599914 | 4 | 0 | 3 |
| WAC | CPE | 0.599438 | 4 | 0 | 3 |
For details and further investigation, click here
