| Full name: bone morphogenetic protein receptor type 1A | Alias Symbol: ALK3|CD292 | ||
| Type: protein-coding gene | Cytoband: 10q23.2 | ||
| Entrez ID: 657 | HGNC ID: HGNC:1076 | Ensembl Gene: ENSG00000107779 | OMIM ID: 601299 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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BMPR1A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway | |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of BMPR1A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMPR1A | 657 | 213578_at | 0.1607 | 0.7856 | |
| GSE20347 | BMPR1A | 657 | 213578_at | 0.1824 | 0.4257 | |
| GSE23400 | BMPR1A | 657 | 204832_s_at | -0.0011 | 0.9836 | |
| GSE26886 | BMPR1A | 657 | 213578_at | 0.9019 | 0.0006 | |
| GSE29001 | BMPR1A | 657 | 213578_at | 0.3509 | 0.1792 | |
| GSE38129 | BMPR1A | 657 | 213578_at | -0.0715 | 0.7656 | |
| GSE45670 | BMPR1A | 657 | 213578_at | -0.5400 | 0.0012 | |
| GSE53622 | BMPR1A | 657 | 8310 | -0.3791 | 0.0008 | |
| GSE53624 | BMPR1A | 657 | 46812 | -0.1678 | 0.0150 | |
| GSE63941 | BMPR1A | 657 | 213578_at | -1.0863 | 0.0020 | |
| GSE77861 | BMPR1A | 657 | 204832_s_at | 0.1396 | 0.5576 | |
| GSE97050 | BMPR1A | A_19_P00804767 | -0.7776 | 0.1156 | ||
| SRP007169 | BMPR1A | 657 | RNAseq | 0.2953 | 0.5725 | |
| SRP008496 | BMPR1A | 657 | RNAseq | 0.8375 | 0.0096 | |
| SRP064894 | BMPR1A | 657 | RNAseq | -0.4025 | 0.0947 | |
| SRP133303 | BMPR1A | 657 | RNAseq | 0.1226 | 0.4215 | |
| SRP159526 | BMPR1A | 657 | RNAseq | 0.1336 | 0.4750 | |
| SRP193095 | BMPR1A | 657 | RNAseq | 0.0266 | 0.7870 | |
| SRP219564 | BMPR1A | 657 | RNAseq | -0.1406 | 0.7918 | |
| TCGA | BMPR1A | 657 | RNAseq | -0.1815 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by BMPR1A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BMPR1A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMPR1A | 657 | 1 | 7 | 22 | |
| GSE20123 | BMPR1A | 657 | 1 | 6 | 23 | |
| GSE43470 | BMPR1A | 657 | 0 | 7 | 36 | |
| GSE46452 | BMPR1A | 657 | 0 | 11 | 48 | |
| GSE47630 | BMPR1A | 657 | 2 | 14 | 24 | |
| GSE54993 | BMPR1A | 657 | 7 | 0 | 63 | |
| GSE54994 | BMPR1A | 657 | 1 | 11 | 41 | |
| GSE60625 | BMPR1A | 657 | 0 | 0 | 11 | |
| GSE74703 | BMPR1A | 657 | 0 | 5 | 31 | |
| GSE74704 | BMPR1A | 657 | 0 | 4 | 16 | |
| TCGA | BMPR1A | 657 | 7 | 27 | 62 |
Total number of gains: 19; Total number of losses: 92; Total Number of normals: 377.
Somatic mutations of BMPR1A:
Generating mutation plots.
Highly correlated genes for BMPR1A:
Showing top 20/1068 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMPR1A | COA5 | 0.784891 | 3 | 0 | 3 |
| BMPR1A | NKAPL | 0.782678 | 3 | 0 | 3 |
| BMPR1A | ZNF496 | 0.777754 | 3 | 0 | 3 |
| BMPR1A | LINC00674 | 0.768826 | 3 | 0 | 3 |
| BMPR1A | BOD1 | 0.736761 | 3 | 0 | 3 |
| BMPR1A | SLC39A13 | 0.728403 | 4 | 0 | 4 |
| BMPR1A | C1orf198 | 0.727182 | 4 | 0 | 4 |
| BMPR1A | COMMD7 | 0.720308 | 3 | 0 | 3 |
| BMPR1A | TRUB1 | 0.71784 | 3 | 0 | 3 |
| BMPR1A | FAM118B | 0.716522 | 3 | 0 | 3 |
| BMPR1A | FIBIN | 0.71145 | 3 | 0 | 3 |
| BMPR1A | FAM160B1 | 0.707145 | 7 | 0 | 7 |
| BMPR1A | LRRC14 | 0.701822 | 3 | 0 | 3 |
| BMPR1A | MYOCD | 0.700854 | 4 | 0 | 4 |
| BMPR1A | ZNF461 | 0.69945 | 3 | 0 | 3 |
| BMPR1A | TSEN15 | 0.698938 | 3 | 0 | 3 |
| BMPR1A | MRPS6 | 0.694609 | 3 | 0 | 3 |
| BMPR1A | SESTD1 | 0.691688 | 5 | 0 | 5 |
| BMPR1A | MYL6B | 0.691356 | 3 | 0 | 3 |
| BMPR1A | MRPS26 | 0.685558 | 3 | 0 | 3 |
For details and further investigation, click here
