PPP1CB

 

Full name: protein phosphatase 1 catalytic subunit beta Alias Symbol: PP1B|PP-1B|PP1beta
Type: protein-coding gene Cytoband: 2p23.2
Entrez ID: 5500 HGNC ID: HGNC:9282 Ensembl Gene: ENSG00000213639 OMIM ID: 600590
Drug and gene relationship at DGIdb

 

PPP1CB involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04114Oocyte meiosis
hsa04261Adrenergic signaling in cardiomyocytes
hsa04270Vascular smooth muscle contraction
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04720Long-term potentiation
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04921Oxytocin signaling pathway
hsa04931Insulin resistance
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa05168Herpes simplex infection
hsa05205Proteoglycans in cancer

 

Expression of PPP1CB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPP1CB 5500 228222_at -0.6759 0.0739
GSE20347 PPP1CB 5500 201407_s_at -0.4174 0.0002
GSE23400 PPP1CB 5500 201409_s_at -0.7472 0.0000
GSE26886 PPP1CB 5500 228222_at -0.2597 0.4617
GSE29001 PPP1CB 5500 201407_s_at -0.5284 0.1469
GSE38129 PPP1CB 5500 201407_s_at -0.5266 0.0000
GSE45670 PPP1CB 5500 201407_s_at -0.2203 0.1614
GSE53622 PPP1CB 5500 102167 -1.0063 0.0000
GSE53624 PPP1CB 5500 102167 -1.0700 0.0000
GSE63941 PPP1CB 5500 228222_at 2.6839 0.0000
GSE77861 PPP1CB 5500 228222_at -0.1760 0.7646
GSE97050 PPP1CB 5500 A_24_P405298 -1.4923 0.0938
SRP007169 PPP1CB 5500 RNAseq -0.9917 0.0008
SRP008496 PPP1CB 5500 RNAseq -0.7392 0.0003
SRP064894 PPP1CB 5500 RNAseq -0.9119 0.0000
SRP133303 PPP1CB 5500 RNAseq -0.5039 0.0006
SRP159526 PPP1CB 5500 RNAseq -0.8166 0.0022
SRP193095 PPP1CB 5500 RNAseq -1.0466 0.0000
SRP219564 PPP1CB 5500 RNAseq -1.0464 0.0037
TCGA PPP1CB 5500 RNAseq -0.0499 0.2133

Upregulated datasets: 1; Downregulated datasets: 4.  

 

Survival by PPP1CB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPP1CB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPP1CB 5500 11 2 17
GSE20123 PPP1CB 5500 11 2 17
GSE43470 PPP1CB 5500 3 1 39
GSE46452 PPP1CB 5500 2 4 53
GSE47630 PPP1CB 5500 8 0 32
GSE54993 PPP1CB 5500 0 6 64
GSE54994 PPP1CB 5500 10 0 43
GSE60625 PPP1CB 5500 0 3 8
GSE74703 PPP1CB 5500 3 0 33
GSE74704 PPP1CB 5500 9 1 10
TCGA PPP1CB 5500 36 2 58

Total number of gains: 93; Total number of losses: 21; Total Number of normals: 374.  

 

Somatic mutations of PPP1CB:

 

Generating mutation plots.

 

Highly correlated genes for PPP1CB:

 

Showing top 20/550 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPP1CBRASSF30.771119404
PPP1CBPPP1R14A0.721772303
PPP1CBFGFR20.715059303
PPP1CBSMTN0.708977404
PPP1CBC3orf700.697097303
PPP1CBRBPMS20.694995404
PPP1CBPPM1L0.694105303
PPP1CBBCHE0.685943504
PPP1CBRGS7BP0.679659403
PPP1CBRERGL0.674064504
PPP1CBUBXN100.6732403
PPP1CBMPP70.669658706
PPP1CBLEAP20.666254303
PPP1CBMYZAP0.665505303
PPP1CBWAC0.665432404
PPP1CBMEF2C-AS10.665208303
PPP1CBFNDC50.664209303
PPP1CBSORCS10.663568403
PPP1CBKLHDC8B0.662268403
PPP1CBARL5A0.660131303

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