| Full name: SRY-box transcription factor 8 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 16p13.3 | ||
| Entrez ID: 30812 | HGNC ID: HGNC:11203 | Ensembl Gene: ENSG00000005513 | OMIM ID: 605923 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX8 | 30812 | 226913_s_at | -0.5807 | 0.3432 | |
| GSE26886 | SOX8 | 30812 | 226913_s_at | 0.4870 | 0.0787 | |
| GSE45670 | SOX8 | 30812 | 226913_s_at | -0.2890 | 0.1564 | |
| GSE53622 | SOX8 | 30812 | 94754 | -0.6558 | 0.0000 | |
| GSE53624 | SOX8 | 30812 | 94754 | -0.8931 | 0.0000 | |
| GSE63941 | SOX8 | 30812 | 226913_s_at | 0.3299 | 0.7278 | |
| GSE77861 | SOX8 | 30812 | 226913_s_at | -0.1291 | 0.1624 | |
| GSE97050 | SOX8 | 30812 | A_23_P66137 | -0.4546 | 0.2467 | |
| SRP219564 | SOX8 | 30812 | RNAseq | -0.6321 | 0.2928 | |
| TCGA | SOX8 | 30812 | RNAseq | -0.8851 | 0.0158 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SOX8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX8 | 30812 | 5 | 5 | 20 | |
| GSE20123 | SOX8 | 30812 | 5 | 4 | 21 | |
| GSE43470 | SOX8 | 30812 | 4 | 7 | 32 | |
| GSE46452 | SOX8 | 30812 | 38 | 1 | 20 | |
| GSE47630 | SOX8 | 30812 | 13 | 6 | 21 | |
| GSE54993 | SOX8 | 30812 | 3 | 5 | 62 | |
| GSE54994 | SOX8 | 30812 | 5 | 9 | 39 | |
| GSE60625 | SOX8 | 30812 | 4 | 0 | 7 | |
| GSE74703 | SOX8 | 30812 | 4 | 5 | 27 | |
| GSE74704 | SOX8 | 30812 | 3 | 2 | 15 | |
| TCGA | SOX8 | 30812 | 20 | 14 | 62 |
Total number of gains: 104; Total number of losses: 58; Total Number of normals: 326.
Somatic mutations of SOX8:
Generating mutation plots.
Highly correlated genes for SOX8:
Showing top 20/110 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX8 | ZCCHC12 | 0.736329 | 3 | 0 | 3 |
| SOX8 | HSPB3 | 0.721449 | 3 | 0 | 3 |
| SOX8 | DHRS12 | 0.712424 | 3 | 0 | 3 |
| SOX8 | STXBP6 | 0.705977 | 4 | 0 | 3 |
| SOX8 | UBE2Q2L | 0.695378 | 3 | 0 | 3 |
| SOX8 | SSBP2 | 0.690155 | 3 | 0 | 3 |
| SOX8 | LINC00472 | 0.667604 | 3 | 0 | 3 |
| SOX8 | ENPP6 | 0.665175 | 4 | 0 | 4 |
| SOX8 | FAM163A | 0.652906 | 4 | 0 | 3 |
| SOX8 | PCMTD1 | 0.652905 | 3 | 0 | 3 |
| SOX8 | PAMR1 | 0.648971 | 4 | 0 | 3 |
| SOX8 | GABRA5 | 0.648798 | 3 | 0 | 3 |
| SOX8 | ANKS1B | 0.642258 | 4 | 0 | 3 |
| SOX8 | FIBIN | 0.634993 | 3 | 0 | 3 |
| SOX8 | ITGBL1 | 0.623744 | 3 | 0 | 3 |
| SOX8 | FAM184A | 0.619168 | 3 | 0 | 3 |
| SOX8 | FGD5 | 0.618037 | 4 | 0 | 3 |
| SOX8 | FBLN2 | 0.614264 | 4 | 0 | 3 |
| SOX8 | DLC1 | 0.613387 | 4 | 0 | 3 |
| SOX8 | YPEL1 | 0.612422 | 3 | 0 | 3 |
For details and further investigation, click here
