| Full name: MLLT10 histone lysine methyltransferase DOT1L cofactor | Alias Symbol: AF10 | ||
| Type: protein-coding gene | Cytoband: 10p12.31 | ||
| Entrez ID: 8028 | HGNC ID: HGNC:16063 | Ensembl Gene: ENSG00000078403 | OMIM ID: 602409 |
| Drug and gene relationship at DGIdb | |||
Expression of MLLT10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MLLT10 | 8028 | 225992_at | -0.5698 | 0.0696 | |
| GSE20347 | MLLT10 | 8028 | 216506_x_at | -0.0580 | 0.6078 | |
| GSE23400 | MLLT10 | 8028 | 205408_at | 0.0896 | 0.1834 | |
| GSE26886 | MLLT10 | 8028 | 225992_at | -0.2890 | 0.2082 | |
| GSE29001 | MLLT10 | 8028 | 205408_at | -0.0679 | 0.7984 | |
| GSE38129 | MLLT10 | 8028 | 216503_s_at | 0.1513 | 0.3720 | |
| GSE45670 | MLLT10 | 8028 | 225992_at | -0.4043 | 0.0094 | |
| GSE53622 | MLLT10 | 8028 | 39391 | -0.2250 | 0.0001 | |
| GSE53624 | MLLT10 | 8028 | 53498 | -0.4073 | 0.0000 | |
| GSE63941 | MLLT10 | 8028 | 225992_at | 0.2575 | 0.5783 | |
| GSE77861 | MLLT10 | 8028 | 225992_at | -0.2414 | 0.4960 | |
| GSE97050 | MLLT10 | 8028 | A_24_P316102 | -0.3209 | 0.2119 | |
| SRP007169 | MLLT10 | 8028 | RNAseq | -0.4877 | 0.2328 | |
| SRP008496 | MLLT10 | 8028 | RNAseq | -0.5761 | 0.0454 | |
| SRP064894 | MLLT10 | 8028 | RNAseq | -0.4725 | 0.0321 | |
| SRP133303 | MLLT10 | 8028 | RNAseq | -0.3362 | 0.0119 | |
| SRP159526 | MLLT10 | 8028 | RNAseq | -0.6890 | 0.0056 | |
| SRP193095 | MLLT10 | 8028 | RNAseq | -0.2830 | 0.0022 | |
| SRP219564 | MLLT10 | 8028 | RNAseq | -0.3583 | 0.2368 | |
| TCGA | MLLT10 | 8028 | RNAseq | 0.0559 | 0.2814 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MLLT10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MLLT10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MLLT10 | 8028 | 5 | 8 | 17 | |
| GSE20123 | MLLT10 | 8028 | 5 | 7 | 18 | |
| GSE43470 | MLLT10 | 8028 | 3 | 4 | 36 | |
| GSE46452 | MLLT10 | 8028 | 1 | 14 | 44 | |
| GSE47630 | MLLT10 | 8028 | 5 | 15 | 20 | |
| GSE54993 | MLLT10 | 8028 | 11 | 0 | 59 | |
| GSE54994 | MLLT10 | 8028 | 3 | 9 | 41 | |
| GSE60625 | MLLT10 | 8028 | 0 | 0 | 11 | |
| GSE74703 | MLLT10 | 8028 | 2 | 2 | 32 | |
| GSE74704 | MLLT10 | 8028 | 0 | 6 | 14 | |
| TCGA | MLLT10 | 8028 | 18 | 25 | 53 |
Total number of gains: 53; Total number of losses: 90; Total Number of normals: 345.
Somatic mutations of MLLT10:
Generating mutation plots.
Highly correlated genes for MLLT10:
Showing top 20/336 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MLLT10 | HDHD2 | 0.761788 | 3 | 0 | 3 |
| MLLT10 | PPP1R3B | 0.744045 | 3 | 0 | 3 |
| MLLT10 | ANKRD28 | 0.741304 | 3 | 0 | 3 |
| MLLT10 | RPUSD4 | 0.738675 | 3 | 0 | 3 |
| MLLT10 | XPC | 0.736881 | 3 | 0 | 3 |
| MLLT10 | ZNF23 | 0.736328 | 3 | 0 | 3 |
| MLLT10 | MIER3 | 0.731131 | 4 | 0 | 4 |
| MLLT10 | BDP1 | 0.727796 | 4 | 0 | 4 |
| MLLT10 | PPP1R2 | 0.727547 | 3 | 0 | 3 |
| MLLT10 | ANKRD13C | 0.724797 | 4 | 0 | 3 |
| MLLT10 | CHMP5 | 0.724373 | 3 | 0 | 3 |
| MLLT10 | TSHZ2 | 0.723957 | 3 | 0 | 3 |
| MLLT10 | WDR36 | 0.720982 | 4 | 0 | 4 |
| MLLT10 | ZFP37 | 0.716528 | 4 | 0 | 3 |
| MLLT10 | NPY1R | 0.710166 | 3 | 0 | 3 |
| MLLT10 | FAM204A | 0.70598 | 4 | 0 | 4 |
| MLLT10 | ARL4C | 0.705043 | 3 | 0 | 3 |
| MLLT10 | CHM | 0.699486 | 5 | 0 | 4 |
| MLLT10 | STX8 | 0.696982 | 3 | 0 | 3 |
| MLLT10 | FOXN3 | 0.695835 | 3 | 0 | 3 |
For details and further investigation, click here
