| Full name: purinergic receptor P2X 2 | Alias Symbol: P2X2 | ||
| Type: protein-coding gene | Cytoband: 12q24.33 | ||
| Entrez ID: 22953 | HGNC ID: HGNC:15459 | Ensembl Gene: ENSG00000187848 | OMIM ID: 600844 |
| Drug and gene relationship at DGIdb | |||
P2RX2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04742 | Taste transduction |
Expression of P2RX2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX2 | 22953 | 224069_x_at | -0.4135 | 0.2278 | |
| GSE20347 | P2RX2 | 22953 | 221356_x_at | -0.0273 | 0.6927 | |
| GSE23400 | P2RX2 | 22953 | 221356_x_at | -0.2914 | 0.0000 | |
| GSE26886 | P2RX2 | 22953 | 221356_x_at | 0.1778 | 0.0821 | |
| GSE29001 | P2RX2 | 22953 | 221356_x_at | -0.1882 | 0.1586 | |
| GSE38129 | P2RX2 | 22953 | 221356_x_at | -0.2557 | 0.0009 | |
| GSE45670 | P2RX2 | 22953 | 224557_x_at | -0.0477 | 0.6742 | |
| GSE53622 | P2RX2 | 22953 | 31141 | -0.4412 | 0.0007 | |
| GSE53624 | P2RX2 | 22953 | 31141 | -0.6000 | 0.0000 | |
| GSE63941 | P2RX2 | 22953 | 221356_x_at | 0.4781 | 0.0250 | |
| GSE77861 | P2RX2 | 22953 | 224557_x_at | -0.1219 | 0.1751 | |
| GSE97050 | P2RX2 | 22953 | A_23_P124003 | -0.6574 | 0.1678 | |
| SRP133303 | P2RX2 | 22953 | RNAseq | -3.0626 | 0.0000 | |
| SRP159526 | P2RX2 | 22953 | RNAseq | -3.9150 | 0.0000 | |
| SRP219564 | P2RX2 | 22953 | RNAseq | -1.7620 | 0.1373 | |
| TCGA | P2RX2 | 22953 | RNAseq | -3.3582 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by P2RX2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX2 | 22953 | 4 | 5 | 21 | |
| GSE20123 | P2RX2 | 22953 | 4 | 5 | 21 | |
| GSE43470 | P2RX2 | 22953 | 3 | 3 | 37 | |
| GSE46452 | P2RX2 | 22953 | 8 | 3 | 48 | |
| GSE47630 | P2RX2 | 22953 | 9 | 3 | 28 | |
| GSE54993 | P2RX2 | 22953 | 0 | 6 | 64 | |
| GSE54994 | P2RX2 | 22953 | 4 | 8 | 41 | |
| GSE60625 | P2RX2 | 22953 | 1 | 0 | 10 | |
| GSE74703 | P2RX2 | 22953 | 2 | 3 | 31 | |
| GSE74704 | P2RX2 | 22953 | 2 | 3 | 15 | |
| TCGA | P2RX2 | 22953 | 21 | 15 | 60 |
Total number of gains: 58; Total number of losses: 54; Total Number of normals: 376.
Somatic mutations of P2RX2:
Generating mutation plots.
Highly correlated genes for P2RX2:
Showing top 20/701 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX2 | STXBP6 | 0.758993 | 4 | 0 | 3 |
| P2RX2 | GDF10 | 0.742628 | 4 | 0 | 4 |
| P2RX2 | WAC | 0.724569 | 3 | 0 | 3 |
| P2RX2 | PGR | 0.711398 | 4 | 0 | 4 |
| P2RX2 | KBTBD11 | 0.698112 | 3 | 0 | 3 |
| P2RX2 | KCNN3 | 0.688804 | 4 | 0 | 4 |
| P2RX2 | CSPG4 | 0.685115 | 3 | 0 | 3 |
| P2RX2 | HS6ST3 | 0.678875 | 4 | 0 | 3 |
| P2RX2 | CYP2A6 | 0.671439 | 7 | 0 | 7 |
| P2RX2 | GREB1L | 0.667108 | 5 | 0 | 5 |
| P2RX2 | WFDC3 | 0.659614 | 3 | 0 | 3 |
| P2RX2 | HAAO | 0.659153 | 7 | 0 | 7 |
| P2RX2 | ATP2A1 | 0.656142 | 5 | 0 | 4 |
| P2RX2 | RIT2 | 0.65602 | 3 | 0 | 3 |
| P2RX2 | RPL29 | 0.654814 | 3 | 0 | 3 |
| P2RX2 | ZMYND10 | 0.652744 | 5 | 0 | 4 |
| P2RX2 | SCARA5 | 0.65132 | 3 | 0 | 3 |
| P2RX2 | NXPH3 | 0.646654 | 7 | 0 | 7 |
| P2RX2 | RUNX1T1 | 0.646046 | 4 | 0 | 3 |
| P2RX2 | WSCD2 | 0.645634 | 7 | 0 | 5 |
For details and further investigation, click here
