| Full name: carboxypeptidase E | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q32.3 | ||
| Entrez ID: 1363 | HGNC ID: HGNC:2303 | Ensembl Gene: ENSG00000109472 | OMIM ID: 114855 |
| Drug and gene relationship at DGIdb | |||
Expression of CPE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CPE | 1363 | 201117_s_at | -1.2014 | 0.1004 | |
| GSE20347 | CPE | 1363 | 201117_s_at | -0.5328 | 0.1748 | |
| GSE23400 | CPE | 1363 | 201116_s_at | -0.5849 | 0.0000 | |
| GSE26886 | CPE | 1363 | 201117_s_at | 1.5278 | 0.0092 | |
| GSE29001 | CPE | 1363 | 201116_s_at | -0.1051 | 0.7599 | |
| GSE38129 | CPE | 1363 | 201117_s_at | -0.6924 | 0.0694 | |
| GSE45670 | CPE | 1363 | 201117_s_at | -1.5623 | 0.0002 | |
| GSE53622 | CPE | 1363 | 4575 | -1.1727 | 0.0000 | |
| GSE53624 | CPE | 1363 | 4575 | -0.9313 | 0.0000 | |
| GSE63941 | CPE | 1363 | 201116_s_at | -1.7545 | 0.4024 | |
| GSE77861 | CPE | 1363 | 201116_s_at | 0.5797 | 0.3313 | |
| GSE97050 | CPE | 1363 | A_23_P259442 | -0.9142 | 0.1012 | |
| SRP007169 | CPE | 1363 | RNAseq | 0.2303 | 0.7107 | |
| SRP008496 | CPE | 1363 | RNAseq | 1.2603 | 0.0975 | |
| SRP064894 | CPE | 1363 | RNAseq | -0.5917 | 0.0468 | |
| SRP133303 | CPE | 1363 | RNAseq | -1.0605 | 0.0000 | |
| SRP159526 | CPE | 1363 | RNAseq | -0.4860 | 0.3743 | |
| SRP193095 | CPE | 1363 | RNAseq | -0.0028 | 0.9909 | |
| SRP219564 | CPE | 1363 | RNAseq | -0.0617 | 0.9266 | |
| TCGA | CPE | 1363 | RNAseq | -0.3042 | 0.0321 |
Upregulated datasets: 1; Downregulated datasets: 3.
Survival by CPE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CPE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CPE | 1363 | 0 | 11 | 19 | |
| GSE20123 | CPE | 1363 | 0 | 11 | 19 | |
| GSE43470 | CPE | 1363 | 0 | 13 | 30 | |
| GSE46452 | CPE | 1363 | 1 | 36 | 22 | |
| GSE47630 | CPE | 1363 | 0 | 22 | 18 | |
| GSE54993 | CPE | 1363 | 10 | 0 | 60 | |
| GSE54994 | CPE | 1363 | 1 | 13 | 39 | |
| GSE60625 | CPE | 1363 | 0 | 0 | 11 | |
| GSE74703 | CPE | 1363 | 0 | 11 | 25 | |
| GSE74704 | CPE | 1363 | 0 | 5 | 15 | |
| TCGA | CPE | 1363 | 11 | 33 | 52 |
Total number of gains: 23; Total number of losses: 155; Total Number of normals: 310.
Somatic mutations of CPE:
Generating mutation plots.
Highly correlated genes for CPE:
Showing top 20/681 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CPE | MRVI1 | 0.757538 | 4 | 0 | 4 |
| CPE | TYW3 | 0.756137 | 3 | 0 | 3 |
| CPE | SLC17A5 | 0.748574 | 3 | 0 | 3 |
| CPE | EPDR1 | 0.74512 | 4 | 0 | 4 |
| CPE | LINC01279 | 0.733647 | 3 | 0 | 3 |
| CPE | FNIP2 | 0.723894 | 4 | 0 | 4 |
| CPE | DAPK1 | 0.723593 | 5 | 0 | 5 |
| CPE | FAM13C | 0.722554 | 4 | 0 | 3 |
| CPE | TRIM32 | 0.722132 | 3 | 0 | 3 |
| CPE | CNRIP1 | 0.717446 | 5 | 0 | 5 |
| CPE | DLC1 | 0.716448 | 8 | 0 | 7 |
| CPE | EID2B | 0.715158 | 3 | 0 | 3 |
| CPE | SGTB | 0.713623 | 3 | 0 | 3 |
| CPE | TMEM167B | 0.712455 | 4 | 0 | 4 |
| CPE | ACRBP | 0.69794 | 3 | 0 | 3 |
| CPE | C9orf64 | 0.697097 | 3 | 0 | 3 |
| CPE | MSRB3 | 0.696886 | 5 | 0 | 4 |
| CPE | C1QTNF7 | 0.696764 | 5 | 0 | 5 |
| CPE | PEG3 | 0.696186 | 6 | 0 | 5 |
| CPE | MCAM | 0.695689 | 6 | 0 | 6 |
For details and further investigation, click here
