| Full name: F-box and WD repeat domain containing 5 | Alias Symbol: DKFZP434B205|MGC20962|Fbw5 | ||
| Type: protein-coding gene | Cytoband: 9q34.3 | ||
| Entrez ID: 54461 | HGNC ID: HGNC:13613 | Ensembl Gene: ENSG00000159069 | OMIM ID: 609072 |
| Drug and gene relationship at DGIdb | |||
Expression of FBXW5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FBXW5 | 54461 | 223050_s_at | -0.2740 | 0.5604 | |
| GSE26886 | FBXW5 | 54461 | 223050_s_at | -0.4677 | 0.0265 | |
| GSE45670 | FBXW5 | 54461 | 223050_s_at | -0.1407 | 0.2042 | |
| GSE53622 | FBXW5 | 54461 | 80509 | -0.8937 | 0.0000 | |
| GSE53624 | FBXW5 | 54461 | 80509 | -0.6425 | 0.0000 | |
| GSE63941 | FBXW5 | 54461 | 223050_s_at | -0.0980 | 0.7910 | |
| GSE77861 | FBXW5 | 54461 | 223050_s_at | -0.3105 | 0.0410 | |
| GSE97050 | FBXW5 | 54461 | A_23_P112397 | -0.4283 | 0.1403 | |
| SRP007169 | FBXW5 | 54461 | RNAseq | -2.1665 | 0.0000 | |
| SRP008496 | FBXW5 | 54461 | RNAseq | -1.9204 | 0.0000 | |
| SRP064894 | FBXW5 | 54461 | RNAseq | 0.0550 | 0.8572 | |
| SRP133303 | FBXW5 | 54461 | RNAseq | -0.5785 | 0.0004 | |
| SRP159526 | FBXW5 | 54461 | RNAseq | -0.4245 | 0.0966 | |
| SRP193095 | FBXW5 | 54461 | RNAseq | -0.7253 | 0.0000 | |
| SRP219564 | FBXW5 | 54461 | RNAseq | -0.5546 | 0.2252 | |
| TCGA | FBXW5 | 54461 | RNAseq | -0.1579 | 0.0005 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by FBXW5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FBXW5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FBXW5 | 54461 | 5 | 7 | 18 | |
| GSE20123 | FBXW5 | 54461 | 5 | 7 | 18 | |
| GSE43470 | FBXW5 | 54461 | 3 | 7 | 33 | |
| GSE46452 | FBXW5 | 54461 | 6 | 13 | 40 | |
| GSE47630 | FBXW5 | 54461 | 6 | 15 | 19 | |
| GSE54993 | FBXW5 | 54461 | 3 | 3 | 64 | |
| GSE54994 | FBXW5 | 54461 | 12 | 8 | 33 | |
| GSE60625 | FBXW5 | 54461 | 0 | 0 | 11 | |
| GSE74703 | FBXW5 | 54461 | 3 | 5 | 28 | |
| GSE74704 | FBXW5 | 54461 | 3 | 5 | 12 | |
| TCGA | FBXW5 | 54461 | 29 | 23 | 44 |
Total number of gains: 75; Total number of losses: 93; Total Number of normals: 320.
Somatic mutations of FBXW5:
Generating mutation plots.
Highly correlated genes for FBXW5:
Showing top 20/1106 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FBXW5 | HK1 | 0.813729 | 3 | 0 | 3 |
| FBXW5 | ANGPTL6 | 0.803276 | 3 | 0 | 3 |
| FBXW5 | ZNF625 | 0.799332 | 3 | 0 | 3 |
| FBXW5 | SULT1C2 | 0.786965 | 3 | 0 | 3 |
| FBXW5 | NPRL2 | 0.77999 | 3 | 0 | 3 |
| FBXW5 | BLOC1S1 | 0.772788 | 6 | 0 | 6 |
| FBXW5 | BBIP1 | 0.769982 | 3 | 0 | 3 |
| FBXW5 | GGA3 | 0.769636 | 4 | 0 | 4 |
| FBXW5 | HEMK1 | 0.753221 | 3 | 0 | 3 |
| FBXW5 | HSDL2 | 0.750608 | 5 | 0 | 5 |
| FBXW5 | TLE2 | 0.749102 | 3 | 0 | 3 |
| FBXW5 | CLEC3B | 0.74476 | 3 | 0 | 3 |
| FBXW5 | UXT | 0.744674 | 3 | 0 | 3 |
| FBXW5 | PDE12 | 0.744418 | 4 | 0 | 4 |
| FBXW5 | WASL | 0.738624 | 3 | 0 | 3 |
| FBXW5 | C22orf31 | 0.7341 | 3 | 0 | 3 |
| FBXW5 | SLC2A4 | 0.73264 | 4 | 0 | 4 |
| FBXW5 | ALDH2 | 0.731212 | 4 | 0 | 4 |
| FBXW5 | OAT | 0.728291 | 4 | 0 | 4 |
| FBXW5 | CCDC12 | 0.727458 | 5 | 0 | 5 |
For details and further investigation, click here
