PRKAA2

 

Full name: protein kinase AMP-activated catalytic subunit alpha 2 Alias Symbol: AMPK|AMPKa2
Type: protein-coding gene Cytoband: 1p32.2
Entrez ID: 5563 HGNC ID: HGNC:9377 Ensembl Gene: ENSG00000162409 OMIM ID: 600497
Drug and gene relationship at DGIdb

 

PRKAA2 involved pathways:

KEGG pathway Description View
hsa04068FoxO signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04213Longevity regulating pathway - multiple species
hsa04710Circadian rhythm
hsa04910Insulin signaling pathway
hsa04920Adipocytokine signaling pathway
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04931Insulin resistance
hsa04932Non-alcoholic fatty liver disease (NAFLD)

 

Expression of PRKAA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKAA2 5563 227892_at -2.5372 0.1292
GSE20347 PRKAA2 5563 207709_at -0.1663 0.0291
GSE23400 PRKAA2 5563 207709_at -0.0800 0.0406
GSE26886 PRKAA2 5563 227892_at -0.7958 0.1187
GSE29001 PRKAA2 5563 207709_at -0.9408 0.0006
GSE38129 PRKAA2 5563 207709_at -0.2922 0.0436
GSE45670 PRKAA2 5563 238489_at -0.4705 0.0001
GSE53622 PRKAA2 5563 8212 -2.8742 0.0000
GSE53624 PRKAA2 5563 8212 -2.7222 0.0000
GSE63941 PRKAA2 5563 227892_at 1.4513 0.2910
GSE77861 PRKAA2 5563 227892_at 0.0266 0.9668
GSE97050 PRKAA2 5563 A_32_P94160 -1.5966 0.1185
SRP007169 PRKAA2 5563 RNAseq -1.7096 0.0176
SRP008496 PRKAA2 5563 RNAseq -1.0703 0.0276
SRP064894 PRKAA2 5563 RNAseq -1.4533 0.0000
SRP133303 PRKAA2 5563 RNAseq -0.7330 0.1203
SRP159526 PRKAA2 5563 RNAseq -0.4280 0.1474
SRP193095 PRKAA2 5563 RNAseq -0.9966 0.0023
SRP219564 PRKAA2 5563 RNAseq -1.1129 0.0933
TCGA PRKAA2 5563 RNAseq -0.9484 0.0047

Upregulated datasets: 0; Downregulated datasets: 5.  

 

Survival by PRKAA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKAA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKAA2 5563 3 4 23
GSE20123 PRKAA2 5563 3 3 24
GSE43470 PRKAA2 5563 6 1 36
GSE46452 PRKAA2 5563 2 1 56
GSE47630 PRKAA2 5563 8 4 28
GSE54993 PRKAA2 5563 0 0 70
GSE54994 PRKAA2 5563 9 2 42
GSE60625 PRKAA2 5563 0 0 11
GSE74703 PRKAA2 5563 5 1 30
GSE74704 PRKAA2 5563 2 0 18
TCGA PRKAA2 5563 10 18 68

Total number of gains: 48; Total number of losses: 34; Total Number of normals: 406.  

 

Somatic mutations of PRKAA2:

 

Generating mutation plots.

 

Highly correlated genes for PRKAA2:

 

Showing top 20/946 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKAA2RAB9B0.800055505
PRKAA2RBPMS20.793141505
PRKAA2XKR40.782578505
PRKAA2ANO50.775079505
PRKAA2WDR480.766191303
PRKAA2ATP1A20.762263706
PRKAA2PDCD40.760064303
PRKAA2RNF1500.759412505
PRKAA2CASQ20.756231707
PRKAA2NFIA0.75058505
PRKAA2PARD3B0.745934404
PRKAA2PDE5A0.744732606
PRKAA2PPM1L0.734455606
PRKAA2FRMD30.732987505
PRKAA2BOC0.729599505
PRKAA2C1QTNF70.726079505
PRKAA2EIF2D0.724544303
PRKAA2EIF4E30.7239605
PRKAA2CLEC3B0.721648303
PRKAA2CHRDL10.721521605

For details and further investigation, click here