| Full name: ring finger protein 146 | Alias Symbol: DKFZp434O1427|dactylidin|dJ351K20.1 | ||
| Type: protein-coding gene | Cytoband: 6q22.33 | ||
| Entrez ID: 81847 | HGNC ID: HGNC:21336 | Ensembl Gene: ENSG00000118518 | OMIM ID: 612137 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of RNF146:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNF146 | 81847 | 223886_s_at | -0.3349 | 0.2989 | |
| GSE20347 | RNF146 | 81847 | 221430_s_at | -0.4543 | 0.0002 | |
| GSE23400 | RNF146 | 81847 | 221430_s_at | -0.2489 | 0.0001 | |
| GSE26886 | RNF146 | 81847 | 223886_s_at | -0.9075 | 0.0012 | |
| GSE29001 | RNF146 | 81847 | 221430_s_at | -0.2939 | 0.0897 | |
| GSE38129 | RNF146 | 81847 | 221430_s_at | -0.3510 | 0.0080 | |
| GSE45670 | RNF146 | 81847 | 223886_s_at | -0.5429 | 0.0010 | |
| GSE53622 | RNF146 | 81847 | 5036 | -0.3762 | 0.0000 | |
| GSE53624 | RNF146 | 81847 | 5036 | -0.4935 | 0.0000 | |
| GSE63941 | RNF146 | 81847 | 223886_s_at | -0.6121 | 0.2731 | |
| GSE77861 | RNF146 | 81847 | 223886_s_at | -0.2279 | 0.2595 | |
| GSE97050 | RNF146 | 81847 | A_23_P257201 | -0.1646 | 0.6480 | |
| SRP007169 | RNF146 | 81847 | RNAseq | -0.7906 | 0.0150 | |
| SRP008496 | RNF146 | 81847 | RNAseq | -0.5552 | 0.0102 | |
| SRP064894 | RNF146 | 81847 | RNAseq | -0.0557 | 0.7897 | |
| SRP133303 | RNF146 | 81847 | RNAseq | -0.3254 | 0.0258 | |
| SRP159526 | RNF146 | 81847 | RNAseq | -0.4348 | 0.0800 | |
| SRP193095 | RNF146 | 81847 | RNAseq | -0.4330 | 0.0000 | |
| SRP219564 | RNF146 | 81847 | RNAseq | -0.2196 | 0.5124 | |
| TCGA | RNF146 | 81847 | RNAseq | -0.2386 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RNF146 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNF146:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNF146 | 81847 | 1 | 4 | 25 | |
| GSE20123 | RNF146 | 81847 | 2 | 3 | 25 | |
| GSE43470 | RNF146 | 81847 | 5 | 0 | 38 | |
| GSE46452 | RNF146 | 81847 | 2 | 11 | 46 | |
| GSE47630 | RNF146 | 81847 | 9 | 4 | 27 | |
| GSE54993 | RNF146 | 81847 | 3 | 3 | 64 | |
| GSE54994 | RNF146 | 81847 | 9 | 7 | 37 | |
| GSE60625 | RNF146 | 81847 | 0 | 1 | 10 | |
| GSE74703 | RNF146 | 81847 | 4 | 0 | 32 | |
| GSE74704 | RNF146 | 81847 | 0 | 1 | 19 | |
| TCGA | RNF146 | 81847 | 10 | 18 | 68 |
Total number of gains: 45; Total number of losses: 52; Total Number of normals: 391.
Somatic mutations of RNF146:
Generating mutation plots.
Highly correlated genes for RNF146:
Showing top 20/1110 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNF146 | STK38 | 0.836663 | 3 | 0 | 3 |
| RNF146 | PLEKHF2 | 0.801736 | 3 | 0 | 3 |
| RNF146 | ZDHHC21 | 0.799639 | 3 | 0 | 3 |
| RNF146 | TANC1 | 0.768098 | 3 | 0 | 3 |
| RNF146 | PDIK1L | 0.758069 | 3 | 0 | 3 |
| RNF146 | ZNF92 | 0.750953 | 3 | 0 | 3 |
| RNF146 | PXK | 0.748582 | 3 | 0 | 3 |
| RNF146 | LSM14A | 0.741757 | 3 | 0 | 3 |
| RNF146 | ZNF416 | 0.739459 | 3 | 0 | 3 |
| RNF146 | ZCCHC10 | 0.729247 | 4 | 0 | 3 |
| RNF146 | FGFR1OP2 | 0.728684 | 3 | 0 | 3 |
| RNF146 | WDR48 | 0.719454 | 4 | 0 | 4 |
| RNF146 | POLK | 0.719039 | 4 | 0 | 4 |
| RNF146 | KCNG2 | 0.712759 | 3 | 0 | 3 |
| RNF146 | EBF2 | 0.711359 | 4 | 0 | 4 |
| RNF146 | SLC2A12 | 0.70937 | 3 | 0 | 3 |
| RNF146 | DDX42 | 0.708762 | 3 | 0 | 3 |
| RNF146 | RABGAP1L | 0.699016 | 5 | 0 | 3 |
| RNF146 | ZNF397 | 0.698497 | 3 | 0 | 3 |
| RNF146 | ACVR2A | 0.695968 | 5 | 0 | 4 |
For details and further investigation, click here
