| Full name: integrator complex subunit 8 | Alias Symbol: FLJ20530|INT8|MGC131633 | ||
| Type: protein-coding gene | Cytoband: 8q22.1 | ||
| Entrez ID: 55656 | HGNC ID: HGNC:26048 | Ensembl Gene: ENSG00000164941 | OMIM ID: 611351 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of INTS8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | INTS8 | 55656 | 218905_at | 0.8953 | 0.0702 | |
| GSE20347 | INTS8 | 55656 | 218905_at | 0.6550 | 0.0004 | |
| GSE23400 | INTS8 | 55656 | 218905_at | 0.6109 | 0.0000 | |
| GSE26886 | INTS8 | 55656 | 218905_at | 0.1579 | 0.4200 | |
| GSE29001 | INTS8 | 55656 | 218905_at | 0.4222 | 0.1416 | |
| GSE38129 | INTS8 | 55656 | 218905_at | 0.6250 | 0.0000 | |
| GSE45670 | INTS8 | 55656 | 218905_at | 0.5572 | 0.0001 | |
| GSE53622 | INTS8 | 55656 | 44997 | 0.6628 | 0.0000 | |
| GSE53624 | INTS8 | 55656 | 44997 | 0.6953 | 0.0000 | |
| GSE63941 | INTS8 | 55656 | 218905_at | 0.9647 | 0.0188 | |
| GSE77861 | INTS8 | 55656 | 218905_at | 0.2397 | 0.2895 | |
| GSE97050 | INTS8 | 55656 | A_23_P43079 | 0.4790 | 0.1733 | |
| SRP007169 | INTS8 | 55656 | RNAseq | 0.1089 | 0.7667 | |
| SRP008496 | INTS8 | 55656 | RNAseq | 0.3681 | 0.1267 | |
| SRP064894 | INTS8 | 55656 | RNAseq | 0.9326 | 0.0000 | |
| SRP133303 | INTS8 | 55656 | RNAseq | 0.5126 | 0.0000 | |
| SRP159526 | INTS8 | 55656 | RNAseq | 0.5568 | 0.0217 | |
| SRP193095 | INTS8 | 55656 | RNAseq | 0.2670 | 0.0015 | |
| SRP219564 | INTS8 | 55656 | RNAseq | 0.4302 | 0.1855 | |
| TCGA | INTS8 | 55656 | RNAseq | 0.2040 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by INTS8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of INTS8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | INTS8 | 55656 | 16 | 0 | 14 | |
| GSE20123 | INTS8 | 55656 | 17 | 0 | 13 | |
| GSE43470 | INTS8 | 55656 | 21 | 1 | 21 | |
| GSE46452 | INTS8 | 55656 | 23 | 0 | 36 | |
| GSE47630 | INTS8 | 55656 | 24 | 0 | 16 | |
| GSE54993 | INTS8 | 55656 | 0 | 20 | 50 | |
| GSE54994 | INTS8 | 55656 | 34 | 1 | 18 | |
| GSE60625 | INTS8 | 55656 | 0 | 4 | 7 | |
| GSE74703 | INTS8 | 55656 | 18 | 1 | 17 | |
| GSE74704 | INTS8 | 55656 | 12 | 0 | 8 | |
| TCGA | INTS8 | 55656 | 56 | 1 | 39 |
Total number of gains: 221; Total number of losses: 28; Total Number of normals: 239.
Somatic mutations of INTS8:
Generating mutation plots.
Highly correlated genes for INTS8:
Showing top 20/1445 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| INTS8 | FIP1L1 | 0.776659 | 3 | 0 | 3 |
| INTS8 | SLC39A3 | 0.775223 | 3 | 0 | 3 |
| INTS8 | WDR59 | 0.767742 | 3 | 0 | 3 |
| INTS8 | DGKD | 0.764651 | 3 | 0 | 3 |
| INTS8 | MTERF3 | 0.758843 | 9 | 0 | 8 |
| INTS8 | NAA15 | 0.753162 | 3 | 0 | 3 |
| INTS8 | SAMD1 | 0.752244 | 5 | 0 | 5 |
| INTS8 | PTCD1 | 0.751483 | 3 | 0 | 3 |
| INTS8 | BOD1 | 0.744715 | 3 | 0 | 3 |
| INTS8 | SLC45A4 | 0.732133 | 5 | 0 | 5 |
| INTS8 | COMMD2 | 0.724454 | 3 | 0 | 3 |
| INTS8 | POLR2K | 0.722742 | 8 | 0 | 8 |
| INTS8 | PDE7A | 0.719787 | 7 | 0 | 7 |
| INTS8 | LAPTM4B | 0.717842 | 11 | 0 | 10 |
| INTS8 | ZNF664 | 0.717552 | 3 | 0 | 3 |
| INTS8 | TUBE1 | 0.716514 | 3 | 0 | 3 |
| INTS8 | PLEKHH1 | 0.713842 | 4 | 0 | 4 |
| INTS8 | CPLX1 | 0.713322 | 3 | 0 | 3 |
| INTS8 | DPY19L4 | 0.712427 | 13 | 0 | 11 |
| INTS8 | MTBP | 0.712329 | 6 | 0 | 5 |
For details and further investigation, click here
